Pox virus

Question 1

Poxvirus characteristics

Answer 1

Has 3 important iruses: smallpox, vaccinia and malluscum contagisum virus.
- largest and most complex virus
- linear DsDNA with disk shaped core.
- contain DNAdepRNA polymearse

Question 2

Transmission of Poxvirus

Answer 2

transmitted via respiratory aerosols
direct contact with skin lesions
or fomites like bedding

Question 3

Pathogensis of smallpox

Answer 3

small pox infects upper respirator tract and local lymph nodes and enter bloods then internal organs are infected and then to blood then to skin

Question 4

what causes teh rash of pox virus

Answer 4

the rash is resuklt of virus replication and damage mediated by Tc cells

Question 5

clinical findings of small pox

Answer 5

incubation period of 1 to 2 weeks
sudden onset of prodromal symptoms then rahs on face and exermities

Question 6

rash progression of small pox

Answer 6

macule-papule-vesicle and crusts in 2 to 3 weeks

Question 7

prevention of small pox

Answer 7

vaccination as it has only 1 serotype and no animla reservoir and antibody response is strong and easily recongized and no subclinical infection

Question 8

vaccines of Small pox

Answer 8

vaccinia immune globulins (VIG) is high titter ab agianst vaccinia used to treat complication of vaccination.

Question 9

mulluscum contagiosum virus

Answer 9

member of poxvirus famiy and causes lesions

Question 10

lesions charchteristics of MCV

Answer 10

small diameter, flesh colored papule on skin or mucus membrane, painless nonpruritic and notinflammed and cup shaped crater with white core composed of hyperplastic epithelial cells with cytoplasmic inclusions

Question 11

transmssion of MCV

Answer 11

by personal contact
sexually