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5: MBOD Get Pumped haha > Pourmattaboid 4 > Flashcards

Pourmattaboid 4 Flashcards

1
Q
  1. What are some major effects of histamine?
A
  1. major mediator of allergic response via mast cells, constricts lungs in bronchospasms, releases HCl in stomach, excitatory neurotransmitter in brain
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2
Q
  1. What does glycine contain both carbon and N2 for synthesis?
A
  1. Heme, Creatinine, purine bases
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3
Q
  1. What is used to make creatinine?
A
  1. Glycine (kidney) arginine (liver)
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4
Q
  1. What converts guanidoacetate to creatinine?
A
  1. SAM
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5
Q
  1. What is used to measure heart malfunction? Kidney malfunction?
A
  1. Serum CK, plasma CK
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6
Q
  1. What is the main function of creatinine phosphate?
A
  1. Store phosphate bonds as energy reserve
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7
Q
  1. What isozyme of creatinine is in muscle? Heart? Brain?
A
  1. MM, MB, BB
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8
Q
  1. What is heme synthesized from?
A
  1. Acetate and Gly
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9
Q
  1. What are poryphins synthesized from?
A
  1. Gly and Succinyl CoA
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10
Q
  1. What is made by decarboxylation of Glu?
A
  1. GABA (using PLP)
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11
Q
  1. What is nitric oxide formed from?
A
  1. Arginine using nitric oxide synthase (NOS) (requires NADPH and oxygen)
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12
Q
  1. What are some functions of NO?
A
  1. Vasodilation, neurotransmitter, helps in respiratory burst of macrophages, inhibits
    platelet aggregation
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13
Q
  1. What are three things Tyr is a precursor to?
A
  1. Pigments‐melanin, T4 and T3 hormones, catecholamines
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14
Q
  1. What causes albinism?
A
  1. Deficiency of tyrosinase, (defect in melanin synthesis pathway)
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15
Q
  1. What is tyrosinase related alibinism called?
A
  1. Type 1 oculocutaneous albinism (on chromosome 11)
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16
Q
  1. What is a type of oculocutaneous albinism found on chromosome 15?
A
  1. Type 2
17
Q
  1. Is type 2 as severe as 1?
A
  1. No
18
Q
  1. Is type 3 as severe as 2?
A
  1. No, can’t notice unless from a dark skinned family
19
Q
  1. What chromosome is ocular albinism associated with?
A
  1. X, effects mostly eye movements
20
Q
  1. What does iodination of Tyr in thyroglobulin lead to?
A
  1. T4/T3
21
Q
  1. How is Tyr converted to Norepi?
A
  1. Tyr –> L Dopa –> Dopa –> Norepi
22
Q
  1. What is norepi converted to in presence of SAM?
A
  1. Epi
23
Q
  1. What does Epi break down to be excreted in urine?
A
  1. Vanillyl mandelic acid
24
Q
  1. What is high vanillyl mandelic acid indicative of?
A
  1. Tumor of chromaffin cells
25
Q
  1. What are some functions of catecholamines?
A
  1. Increase BP, HR,RR, muscle strength, etc.
26
Q
  1. What is involved in synthesis of serotonin and melatonin (AA)?
A
  1. Trp
27
Q
  1. What is the function of serotonin?
A
  1. Regulate anger, body temp, mood, sleep, vomiting, sexuality, appetite
28
Q
  1. What is the function of melatonin?
A
  1. Darkness hormone (circadian cycle), released from pineal gland
29
Q
  1. T or F: Serotonin is a diamine neurotransmitter
A
  1. F, monoamine
30
Q
  1. What have low levels of serotonin been associated with?
A
  1. OCD, migraine, IBS, tinnitus, fibromyalgia,etc.
31
Q
  1. How is melatonin synthesized from serotonin?
A
  1. Acetylation via acetylCoA and methylation via SAM

5: MBOD Get Pumped haha (7 decks)

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