Potentially Toxic and/or Caution Herbs Flashcards
What are some of the indications of Aconitum napellus?
“Monkshood”
Actions: anodyne, anti-neuralgic
Neuralgic pain: trigeminal neuralgia
Sciatic pain
Ovarian cysts ( In Turska’s formula)
What are the systems affected by toxic doses of Aconitum napellus?
“Monkshood”
CNS and cardiovascular systems
What is considered a fatal dose of Aconitum napellus?
“Monkshood”
1 tsp to 5 mL
What are the signs and symptoms of Aconitum napellus poisoning?
“Monkshood”
Paresthesias
Nausea/Vomiting
Dyspnea
Chills
Hypotension, ventricular fibrillation
What is considered a safe dose of Aconitum napellus?
“Monkshood”
1-10 drops of tincture 4 oz water
What are the indications for Arnica montana?
Actions: topical vulnerary, anodyne
Bruises
Small Wounds
Sprains/ strains
Myalgia and joint inflammation
By what route of administration is Arnica montana given?
Topical
What are the contraindications for Arnica montana?
Internal Use
Over large areas of broken skin
What are the signs of toxicity for Arnica montana?
Tachy or bradycardia
Hypertension
Symptoms of muscular weakness, gastroenteritis, dyspnea, arrhythmia, and death
What are the indications for Atropa Belladonna?
“Belladona, Devils Cherries”
Actions: anti-spasmotic, anti-cholinergic, anodyne especially for GI tract
GI: Colitis, cholecystitis, GERD, gastritis, PUD
What is the mechanism of action of Atropa Belladonna?
“Belladonna; Devils Cherries”
Blocks muscarine acetylcholine receptors resulting in smooth muscle relaxation
What are the contraindication for Atropa Belladonna?
“Belladonna, Devils Cherries”
Lactation and pregnancy
BPH, urinary retention
Cardia, tachycardia, arrhythmias
Closed angle glaucoma
Pulmonary edema
GI stenosis, megacolon, intestinal obstruction
Use in children
What are the signs of toxicity for Atropa Belladonna?
“Belladonna, Devils Cherries”
Dilate pupils
Dry mouth, eyes and bronchi
Tachycardia
Urinary retention
Hot, dry flushed skin
Respiratory depression and coma may develop
What is the usual dose of Atropa Belladonna?
1-15 drops of 1:10 tincture in 4 oz of water. 1 teaspoon of mixture is taken as dose
What alkaloid is most associated with Belladonna’s actions and toxicity?
Belladonna; Devil’s cherries
Atropine
What are the indications for Baptisia tinctoria?
“Wild Indigo”
Actions: alternativem anti-microbial, lymphagogue
Generally used for infection: sinusitis, pharyngitis, tonsilitis
Mastitis, vaginitis
What are the contraindications for Baptisia tinctoria?
“Wild Indigo”
Pregnancy or high dose chronic use
What are the signs of toxicity for Baptisia tinctoria?
“Wild Indigo”
Anorexia
N/V/D/GI spasms
Hypersalivation
Tachypnea
Tachycardia
Respiratory paralysis
What effect does Baptisia tinctoria have in large doses?
“Wild Indigo”
Emetic
What are the indications Bryonia Alba?
“White Bryony”
Actions: Anodyne, sedative, immunomodulating especially for serous membranes
Lungs: Pleuritis, pneumonia and sharp, painful coughs
Orchitis, ovarian cysts (Turska’s formula)
Pericarditis
What are the contraindications of Bryonia Alba?
“White Bryony”
Pregnancy and lactation
What are the signs of toxicity of Bryonia Alba?
GI: Colic, vomiting, diarrhea, gastroenteritis
Bradycardia
Hypothermia
Headache
Delirium
Weakness and collapse
What is an indicated dose for Bryonia Alba?
5-20 drops tincture added to 4 oz water then 1 tsp of mixture is taken as dose
What are the contraindications for Bryonia cretica diocia?
“Red Bryony”
Internal use: Gi inflammation, diarrhea and vomiting
What are the indications for Capsicum frutescens?
“Cayenne”
Actions: Circulatory stimulant, anti-platelet aggregate, diaphoretic, rubefacient, digestive stimulant, anodyne
Cardiovascular: atherosclerosis, hypercoagulation, Raynaud’s phenomenon
Respiratory: Asthma
GI: Hypochlorhydria, maldigestion, gas, biliary insufficiency
External: RA, OA, Diabetic neuropathy
Small amount added to formula as synergizer
What are some of the toxicities of Capsiucm frutescens?
“Cayenne”
GI irritation: N/V
Topical irritation
What are the contraindications for Capsicum frustescens?
“Cayenne”
Acute PUD, biliary obstruction
Hypertension
Topical application near the eyes or mucosal membranes
Could potentiate anti-coagulation medications
What are the indications for Cassia angustifolia?
“Senna”
Actions: stimulating laxative
Atonic, non-inflammatory constipation: acts as an irritant laxative
What are the contraindications for Cassia angustifolia?
“Senna”
Pregnancy, use longer than 10 days, intestinal obstruction, IBD, bulimia/anorexia
What are the signs of toxicity for Cassia angustifolia?
“Senna”
Can lead to laxative dependence
Overuse can lead to hypokalemia
What group of compounds are responsible for the actions of senna?
Anthraquinone glycosides
What are the indications for Caulophyllum thalictroides?
“Blue Cohosh”
Actions: anti- spasmotic, uterine tonic, parturifacient
Amenorrhea, menorrhagia
Dymenorrhea
Mittleschmerz
Facilitate labor in last weeks of pregnancy
Rheumatic and muscle pain
What are the contraindications for Caulophyllum thalictroides?
Early Pregnancy
What are the signs of toxicity for Chamaelirium luteum?
“False unicorn root”
GI: N/V
Thirst
Headache
Muscle Weakness
Cardiovascular collapse
Convulsion
What are the indications for Chamaelirium luteum?
“False unicorn root”
Actions : Uterine Tonic
Amenorrhea, dysmenorrhea, endometriosis, infertility, fibroids, menorrhagia
Uterine Prolapse
What are the contraindications for Chamaelirium luteum?
Early Pregnancy
What are the signs of toxicity for Chamaelirium luteum?
None Known
What are the indications for Chelidonium majus?
“Greater Celandine”
Actions: Choleretic, cholagogue, bitter, hepatoprotective
Common and plantar warts (milky juice used topically)
Liver and gallbladder disorders: hepatic congestion, biliary insufficiency
What are the contraindications for Chelidonium majus?
“Greater Celandine”
Pregnancy, lactation, long term use, bile duct obstruction
What are the signs of toxicity for Chelidonium majus?
“Greater Celandine”
N/V, burning in the mouth, abdominal pain, diarrhea
What are the indications for Cimicifuga (Actaea) racemosa?
“Black Cohosh”
Actions: Uterine tonic, spasmolytic, anti-rheumatic
Dysmenorrhea
Infertility
Menopause symptoms
PMS
Skeletal muscle pain, RA
What are the contraindications for Cimicifuga (Actaea) racemosa?
“Black Cohosh”
Early pregnancy, lactation
What are the signs of toxicity for Cimicifuga (Actaea) racemosa?
“Black Cohosh”
Sedation
Blurred vision
Large doses: N/V, headache, bradycardia, hypotension
What are the indications for Convallaria majalis?
“Lily of the valley”
Actions: Positive inotrophic, negatice chronotropic, diuretic
Arrhythmias
Congestive Heart Failure
Safer alternative to digitalis
What are the contraindications for Convallaria majalis?
“Lily of the Valley”
Pregnancy and lactation, hypokalemia, renal failure
What are the signs of toxicity for Convallaria majalis?
N/V, bradycardia, visual disturbances
What compounds are responsible for the actions and toxicity of Convallaria?
Cardiac glycosides
What are the indications for Datura Stramonium?
“Jimson weed”
Actions: Anti-spasmotic, anodyne especially in respiratory tract
Acute treatment of asthma
What is the mechanism of action for Datura stramonium?
“Jimson Weed”
It is an anti-cholinergic
What are the contraindications for Datura stramonium?
“Jimson Weed”
Lactation and pregnancy
BPH or urinary retention
Cardiac: tachycardia, arrhythmias
Acute closed angle glaucoma
Pulmonary Edema
GI stenosis megacolon
What are the signs of toxicity for Datura stramonium?
“Jimson Weed”
Dilated pupils
Dry mouth, eyes, and bronchi
Tachycardia
Urinary retention
Constipation
Hot, dry flushed skin
Respiratory depression and comma may develop
What is a safe dose of Datura stramonium?
“Jimson Weed”
1- 10 drops of 1:10 tincture per day
What are the indications for Digitalis purpurea?
“Foxglove”
Action: Cardiac glycoside, anti-arrhythmic, diuretic
Congestive Hear Failure
Arrythmias
Crude herb is no longer commonly used
What are the contraindications for Digitalis purpurea?
“Foxglove”
Heart Block
Bradycardia
Fibrillation
Hypokalemia
Pregnancy/Lactation
What are the signs of toxicity for Digitalis purpurea?
“Foxglove”
Nausea and vomiting
Loss of appetite
Arrhythmias
Bradycardia
What are the drug interactions of Digitalis purpurpea?
“Foxglove”
Corticosteroids
Beta Blockers
Diuretics
Quinidine
What compound from Digitalis is now used as a drug, being much more toxic in this isolated form?
Digoxin
What are the indications for Ephedra sinica?
“Ephedra, Ma Hung”
Actions: Alpha adrenergic agonist: Brochodilating, mast cell stabilizing, hypertensive, thermogenic
Sinusitis
Asthma
COPD
Allergic rhinitis
What are the contraindications for Ephedra sinica?
“Ephedra”
Pregnancy/lactation
BPH
HTN
BM
Hyperthyroidism
Glaucoma
What are the signs of toxicity for Ephedra sinica?
“Ephedra”
Sympathomimetic signs:
N/V
Vertigo
Sweating
Tachycardia
Dizziness, weakness
What are the some drug interactions that we need to be aware of with Ephedra sinica?
“Ephedra, Ma Hung”
MAO inhibitors
Anti-hypertensive medications
What compounds in Ephedra sinica are responsible for its cardiovascular toxicity?
Ephedrine, pseudoephedrine
What are the indications for Gelsemium sempervirens?
“Yellow Jasmine”
Actions: Anodyne, anti-spasmotic, sedative
Dymenorrhea
Biliary Colic
Ovarian Cysts (Turska’s Formula)
Neuralgia
Insomnia
What are the contraindications for Gelsemium sempervirens?
“Yellow Jasmine”
Pregnancy/lactation, hypotension, combination with other CNS depressants
What are the signs of toxicity for Gelsemiun sempervirens?
“Yellow Jasmine”
Depresses cardiac and respiratory centers
Diplopia
Ptosis
Weakness
Hypotension
Respiratory Failure
What are indications for Glycyrrhiza glabra?
“Licorice”
Actions: Adaptogen, anti-viral , immunomodulating, demulcent, anti-inflammatory, phytoestrogen
Hypotension
GI: PUD, GERD, gastritis, IBD
Viral hepatitis, cirrhosis
Adrenal insufficiency
Menopausal symptoms
HSV infections
HIV/AIDS
Post-herpetic neuralgia
Dry Cough
What are the contraindications for Glycyrrhiza glabra?
“Licorice”
Hypertension
Estrogen-dependent cancer (theoretical)
Pregnancy ( high dose)
Hyperaldosteronism
What are the signs of toxicity for Glycyrrhizza glabra?
HTN
Aldosterone-life effect: fatigue, weight loss, edema
Hypokalemia
How does glycyrrhizin cause potassium loss?
Inhibition of 17 beta-hyroxysteroid dehydrogenase in the kidneys, preventing cortisol catabolism
What are indications for Hydrastis canadensis?
“Golden Seal”
Actions: Anti-microbial , immunomodulating bitter, anti- neoplastic
GI: Gastroenteritis, maldigestion, hypochlorhydria
Mastitis
Intestinal parasitic infections
H. pylori infection and PUD
Viral and bacterial inefections
Cancer
What are the contraindications for Hydrastis canadensis?
Late pregnancy, long term use, avoid long term active PUD. High doses may interfere with B vitamin metabolism
What are the indications for Hyoscyamus niger?
“Henbane”
Actions: spasmolytic, andoyne especially in GU tract
UTI, interstitial cystitis
Motion sickness
What are the contraindications for Hyoscyamus niger?
“Hendane”
BPH
Acute close glaucoma
Pregnancy/Lactation
Tachycardia, arrhythmia
What are the signs of toxicity for Hyoscyamus niger?
“Hendane”
Anti-cholinergic effects: dry mouth, mydriasis, dry eyes, blurred vision, constipation, tachycardia than bradycardia
What is a safe dose of Hyoscyamus niger?
2-10 drops of tincture
What are the indications for Hypericum perforatum?
St. John’s Wart
Actions: antiviral, inflammation modulator, nervine/antidepressant
Depression
Cancer
HSV, CMV, EBV or HIV infection
What are the contraindications for Hypericum perforatum?
“St. Johns Wart”
Combination with SSRI/SSNRI, 5-HTP, combined with MAO inhibitors and tyramine; use with OCP (decrease effectiveness) intense sun exposure with high doses
What are the signs of toxicity for Hypericum perforatum?
“St. John Wart”
May cause photosensitivity
What is the effect of Hypericum Perforatum on CYP3A4? What constituent is responsible fo this effect?
“St. John Wart”
Induces CYP450:3A4 in the gut, hyperforin
What are the indications for Iris versicolor?
“Blue Flag”
Actions: Cholagogue, alternative, lymphagogue
Biliary Insufficiency
Chronic Skin Disease
Soft glandular enlargement
What are the contraindications for Iris versicolor?
“Blue Flag”
Doses > 1 ml TID, biliary obstruction, pregnancy/lactation
What are the signs of toxicity for Iris versicolor?
“Blue Flag”
Violent emetic action: N/V
Violent Diarrhea
Burning in mouth and throat
What are the indications for Juniperus communis?
“Juniper”
Actions: Digestive stimulant, aquaretic, antimicrobial
Biliary insufficiency, maldigestion
UTI
Chronic arthritis, myalgias and gout (topical oil)
What are the contraindications for Juniperus communis?
“Juniper”
Long term use
Biliary obstruction, active PUD
Renal Inflammation
Pregnancy
What are the signs of toxicity for Juniperus communis?
Juniper
Kidney damage (controversial)
What are the indications for Larrea tridentata?
“Chaparral”
Actions: Inflammation modulating, antioxidant, anti-neoplastic, anti-microbial
Cancer
Severe infections especially URI
Allergic rhinitis
HSV (topically)
What are the contraindications for Larrea tridentata?
“Chaparral”
Chronic liver disease, long term use, pregnacy
What are the signs of toxicity for Larrea tridentata?
Hepatotoxic: elevated serum transaminases, jaundice, itching, brown urine, fatigue, N/V, and other signs of liver damage
What famous alkaloid is found in Lobelia inflata and what is its action?
“Indian Tobacco”
Lobeline; nicotinic receptor agonist
What are the indications for Lobelia inflata?
Actions: Stimulating expectorant, spasmolytic, emetic
Asthma
Wet Cough
Chronic Lung Disease
URI
Smoking Cessation
What are the contraindications for Lobelia inflata?
Pregnancy/lactation, high doses, chronic use, elderly and debilitation
What are the signs of toxicity for Lobelia inflata?
Severe N/V
What are the indications for Lomatium dissectum?
“Indian Balsam”
Actions: Antiviral, immune stimulant
Lung Infections: Bronchitis
EBV
HPV
What are the contraindications for Lomatium dissectum?
“Indian Balsam”
Use of unprocessed fresh root, pregnancy
What are the signs of toxicity for Lomatium dissectum?
“Indian Balsam”
Whole body rash from unprocessed fresh root
What are the indications for Lycopus virginicus?
“Bugleweed”
Actions: Thyrosuppressive. suppresses gonadotrophic production
Hyperthyroidism and Grave’s Disease
What are the contraindications for Lycopus virgincus?
“Bugleweed”
Hypothyroidism, infertility, pregnancy/lactation, children
What are the indications for Melaleuca alterniflora?
Tea Tree
Actions: anti-microbial, anti-fungal, vulnerary with affinity for the skin
Tinea pedis, onychomycosis
Candidiasis: vaginal, thrush
Dermatophytoses
Acne
What are the contraindications for Melaleuca alterniflora?
“Tea Tree”
Internal use, application over large area of broken skin, undiluted use of essential oil
What are the signs of toxicity for Melaleuca alterniflora?
“Tea Tree”
Internal: N/V/D, abdominal pain
External: Contact dermatitis in sensitive individuals
What are the indications for Mitchella repens?
“Partridge Berry”
Actions: Uterine tonic, astringent, nervine parturifacient
Facilitation or stimulation of labor
Dysmenorrhea
Menorrhagia
What are the contraindications for Mitchella repens?
“Partridge Berry”
Early pregnancy
What are the signs of toxicity fro Mitchella repens?
None Known
What category of constituents is yohimbine?
Indole Alkaloid
What are the indications for Pausinystalia yohimbe?
Actions: Alpha 2-adrenergic antagonist, aphrodisiac
Erectile Dysfunction
Narcolepsy
Depression: mild MAO inhibitor
What are the contraindications for Pausinystalia yohimbe?
Severe Edema
Kidney Disease
Psychiatric Disorders: PTSD, panic attacks, anxiety
Pregnancy/Lactation
PUD
What are the signs of toxicity for Pausinystalia yohimbe?
Anxiety and panic attacks
Hypertension and tachycardia
Headaches
Dizziness
Insomnia
What are the indications for Phytolacca americana?
“Poke Root”
Actions: Lymphogogue, alternative
Lympadenopathy
Ovarain cysts (Turska’s Formula)
Mastitis, orchitis, parotitis
Tonsillitis
What are the contraindications for Phytolacca americana?
“Poke Root”
Large internal doses, pregnancy/lactation (okay short term for mastitis topically)
What are the signs of toxicity for Phytolacca americana?
“Poke Root”
N/V/D, abdominal cramping
Bradypnea, respiratory depression
Bradycardia, hypotension
What are the indications for Piper methysticum?
“Kava Kava”
Actions: Anxiolytic, anodyne, anti-spasmotic, sedative
Interstitial cystitis/ UTI
IBS
Anxiety
What are the contraindication for Piper methysticum?
“Kava Kava”
Anti-psychotic medication, long term internal use of high doses
What are the signs of toxicity for Piper methysticum?
Kava Kava
Long term, high dose use causes skin rash
Increased liver enzymes
What are the indicates for Podophyllum peltaptum?
“Mayapple, American Mandrake”
Actions: antiviral, antineoplastic, cholagogue, lymphagogue
No longer used as crude herb
Common, plantar, genital warts
Cancer
What are the contraindications for Podophyllum peltatum?
“Mayapple, American Mandrake”
Use on skin around eyes and mucous membranes, internal use
What are they signs of toxicity for Podophyllum peltatum?
Strongly cathartic
GI irritation
N/V/D
Parasthesia and hypotension
What are the indication for Pulsatilla vulgaris?
What are the contraindication for Pulsatilla vulgaris?
What are the signs of toxicity for Pulsatilla vulgaris?
What are the indications for for Rauwolfia serpentina?
What are the contraidications for Rauwolfia serpentina?
How does resperine work?
What are the signs of toxicity for Rauwolfia serpentina?
What are the indications for Ricinis communis?
What are the contraindications for Ricinis communis?
What are the signs of toxicity for Ricinis communis?
What are the indications for Sanguinaria canadensis?
What are the contraindications for Sanguinaria canadensis?
What are the signs of toxicity for sanguinaria canadensis?
What is the name of the red alkaloid in sanguinaria canadensis?
What are the indications for selenicereus grandiflorus?
What are the signs of toxicity of selenicereus grandiflorus?
What are the contraindications for selenicereus grandiflorus?
What is considered a safe dose for selenicereus grandiflorus?
What are the indications for Symphytum officinale?
What are the contraindications for Symphytum officinale?
What compounds contained in symphytum officinale make it potentially toxic?
What are the signs of toxicity for Symphytum officinale?
What are the indications for Thuja occidentalis?
What are the contraindications for Thuja occidentalis?
What are the signs of toxicity for Thuja occidentalis?
What are the indications for Tanacetum parhtenium?
What are the contraindications for tanacetum parthenium?
What are the signs of toxicity for Tanacetum parthenium?
What are the indications for Tanacetum vulagre?
What are the contraindications for Tanacetum?
What are the signs of toxicity for Tanacetum vulgare?
What are the indications for Veratrum viride?
What are the contraindications for Veratrum viride?
What are the signs of toxicity for Veratrum viride?
What are the indications for Viscum album?
What are the contraindications for Viscum album?