Posterior pituitary -Table 1 Flashcards
what is desmopressin?
analogue of ADH (PO and nasal spray)- used to tx central DI- dosing is very individualized
Hypernatremia is a complication of what?
Untreated DI, not enough ADH
DI is what?
inability to concentrate urine- central and nephregenic
What are the causes of nephrogenic DI?
idiopathic, familial, chronic renal dz, Acute renal failure,
DI diagnosis
Urine osmolality
what is the water deprivation test?
no fluids for 12-18hrs, give 5units vasopressin subQ and measure urine osmo after 1 hr.- central(urine concentrats)
what is the treatment for central DI?
DDAVP, Chlorpropamide, Carvemazepine
How do you treat nephrogenic DI?
low NA diet, thiazide, indomethocin
SiADH characteristics?
too much ADH, hyponatremia, edema
what are the ddx for SiADH?
CHF(cannot walk and talk), liver cirrhosis
endocrine without edema
Adrenal insufficiency (low aldosterone), hyponatremia
acute siadh presentation?
water intoxicaiton, ha, confusion, n/v, anorexia, coma,
What is the primary SiADH treatment?
Fluid restriction
How do you treat ACTH deficincy?
Hydrocortisone, cortisone acetate, prednisone
How do you treat TSH deficiency?
Levothyroxone