Posterior Pituitary Flashcards
Two hormones made by post pit
ADH and oxytocin
Two causes of SIADH
Brain lesion or lung lesion that secretes ADH
What would the MCC of an ADH lung/brain secreting lesion be
malignancy (but any lung/brain lesion can do it) granuloma/PNA
What is the fxn of ADH
antidiuretic hormone - opposite of diuresis - kidneys reabsorb water
Will urine be produced in SIADH?
Yes
What will urine in SIADH look like?
Concentrated and salty
Increased Uosm and Una
What do you think if you see increased urine osmoles and increased urine sodium
Inappropriate secretion of ADH
Presentation of SIADH
Hyponatremia
What is presentation of hyponatremia
SALTLOSS Stupor/coma Anorexia - nausea/vomiting Lethargy Tendon reflexes decreased Limp muscles (weakness) Orthostatic hypotension Seizures/headache Stomach cramping
Dx of SIADH
Increased: Una and Uosm (if these are ever in same direction something is wrong)
Tx of SIADH
Water restriction and reverse underlying dz
or demclocyline whatever that is
Why is serum sodium low and serum sodium high in SIADH?
Body knows there’s too much water because it is reabsorbing it all (thanks high ADH). Water follows salt. So to try to stop body from reabsorbing MORE water, it shuts off reabsorption of sodium by shutting off aldosterone production
Two types of diabetes insipidus
Central and nephrogenic
What causes central DI
Break in production of ADH
What causes nephrogenic DI
Break in receptors of ADH on kidney
