POST MIDTERM Flashcards
MC antibiotics that cause diarrhea/colitis
-azithromycin- diarrhea
-colitis (c. diff) - clindamycin, ampicillin, 3rd generation of cephalosporins, Fluoroquinolones
what can put you at risk for C. diff
-Severely ill/malnourished
-Chemotherapy
-Multiple antibiotics
-Tube feeds
-PPI* - long term bc your raising pH of stomach
-Surgery
-IBD- flora is not as strong
-age
-health care
C. diff diagnostics
-stool sample- first choice for typical course
-toxin a- enterotoxic
-toxin b- cytotoxic
-GDH antigen test (carrier) and toxin A and B tests
-both + -> c. diff present
-one + and one - -> PCR for tcdB and tcdC
C. diff treatment
-fidaxomicin
-vancomycin
-metronidazole (not used anymore)
-1st reoccurrence- same antibiotics but longer with biologic -> TAPER
-3 CDI (2 reoccurrence) - FMT- fecal microbiota transplantation
Different severity of C. diff
-C. diff w/ diarrhea- stool sample, leukocytosis
-severe C. diff- thumbprinting, pseudomembranous colitis -> sigmoidoscopy/colonoscopy
-fulminant- toxic megacolon, perforation, paralytic ileus and colonic dilatation-> CT -> colectomy can be life saving
-Abdominal radiograph or CT**- fulminant dx -> looks for thickening of sigmoid colon in pseudomembrane colitis, toxic megacolon, thumbprinting
vitamin K
-controls formation of coagulation factors 2, 7, 9, 10 -> activate factors 10 and 2
-disseminated intravascular coagulation (DIC)- decreased platelet and fibrinogen
thiamine (B1)
-water soluble - cant produce
-absorbed in jejunum
-must administer B1 with dextrose
-whole grains, meat, fish, eggs, milk, vegetable’s, legumes, orange, tomato
-early- anorexia, cramps, paresthesia, irritability
-advanced- wet and dry beriberi
-dry beriberi- legs>arm, symmetric -> Wernicke-Korsakoff syndrome
-wernicke encephalopathy- acute, COAT (confusion, opth, ataxia, thiamine)
-korsakoff- RACK
-dx- Erythrocyte thiamine transketolase (ETKA)
-only half recover- parental thiamine
niacin (B3)
-synthesized from tryptophan
-NAD, NADP
-cereal, vegetable’s, dairy product, tuna, beef, liver, chicken
-metabolic disorders
-early- anorexia, weakness, irritability, glossitis, stomatitis, wt loss
-advanced- pellagra - dementia, dermatitis, dermatitis
vitamin C
-cannot synthesize
-water soluble
-fruits and vegetables
-chronic illness, old, poor, alc
-early- weakness
-advanced- scurvy -> perifollicular hyperkeratotic papules, hemarthroses, subperiosteal hemorrhages, poor wound healing
-late stages- edema, oliguria, intracerebral hemorrhage, death
-large amount of vit c -> gastritis, farting, diarrhea, stones, false neg hemocult
vitamin A
-mineral oil abuse, poor
-early- night blindness, xerosis, bitot spots
-late- ulceration and necrosis (keratomalacia), perforation, endophthalmitis (purulent inflammation of intraocular fluid), blindness, hyperkeratinization of skin, loss of taste
vitamin D
-anticonvulsants (phenytoin), cholestyramine
-rickets 1 and 2
E. coli
-fecal-oral, contaminated meats
-enterotoxigenic e coli - non-inflammatory watery diarrhea
-shiga toxin producing e coli (O157:H7)- inflammatory bloody diarrhea -> MC cause of bloody diarrhea
-travelers diarrhea
inflammatory diarrhea vs non-inflammtory
INFLAMMTORY
-bleeding
-colon
-fecal leukocytes
-campylobacter
-salmonella
-shiga toxin producing e coli
-shigella
-vibrio
NONINFLAMMTORY
-small bowel
-secretory, watery
-hypokalemia, metabolic acidosis, dehydration
-norovirus, rotovirus
-giardia, crytosporidum, cyclospora
-enterotoxin- s. aureus, costridium
-cholerae
when to obtain stool specimen and what to order
-fever, hypovolemia, ≥6 unformed stools per 24 hours, severe abdominal pain, hospitalization, hypotensive, high pulse
-bloody diarrhea
-age ≥ 70 years, cardiac disease, immunosuppression, inflammatory bowel disease, pregnancy
-Symptoms persisting >1 week
-Public health concerns
-* consider empiric therapy if sick enough
-fecal leuks* (chronic IBD), parasite, bacteria, c. diff, giardia, viruses
acute diarrhea treatment
-cipro, levofloxacin, azithromycin
-shigella- fluoroquinolone
-cholera- doxycyclin, azithromycin
-C. diff- vancomycin
-giardia- metronidazole, tinidazole
-travelers diarrhea- fluoroquinolone
causes of osmotic diarrhea
-disaccharidase deficiency (lactose intolerance)
-lactulose
-sorbitol
-olestra
-magnesium containing medication
secretory diarrhea causes
-occurs with fasting
-endocrine tumors
-bile salt malabsorption
-laxative abuse
alarm features in pts with chronic diarrhea*
-onset after 50
-rectal bleeding or melena
-nocturnal pain or diarrhea
-unexplained weight loss, fever, systemic symptoms
-lab abnormalities (iron deficiency anemia, elevated ESR/CRP, elevated fecal calprotectin, fecal occult blood present)
-first degree relative with inflammatory bowel disease or colorectal cancer or celiac
chronic diarrhea dx and tx
-consider abdominal CT (pancreas), small bowel series or MR enterography (Crohns), breath tests (lactose, SIBO)
-treat underlying condition***
-anticholinergics/antispasmodics - dicyclomine and hyoscyamine -> IBS
-bile salt binding resin- cholestyramine- tx for ileal resection
exocrine pancreatic insufficiency
-ddx- celiac, lactose intol, SIBO, giardia*
-stool and then MRI or CT
-giardia -> egd and colonoscopy
bacterial overgrowth
-bacterial deconjugation of bile salts
-gastric achlorhydria
-anatomical abnormality- ileocecal vale, SI diverticulum, obstruction, blind loop
-motility disorder- scleroderma, diabetic enteropathy
-fistula
-malabsorption in severe cases
-breath test
-correct anatomic defect
-rifaximin**