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Breast Cancer > Post-Lumpectomy RT > Flashcards

Post-Lumpectomy RT Flashcards

1
Q

NSABP B-06

How long of a follow-up data do we have?

A

1976-1978

20 yrs

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2
Q

NSABP B-06

How many subjects

A

1843

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3
Q

NSABP B-06

Treatment Arms?

A

Mastectomy alone
Lumpectomy alone
Lumpectomy + WB-RT

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4
Q

NSABP B-06

Tumor Requirements

A 
Stage I-II
Size < 4 cm
Mobile tumor
Mobile LNs
-ve margins
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5
Q

NSABP B-06

What level of LNs were removed

A

I & II

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6
Q

NSABP B-06

What was the RT dose?

A

50 Gy / 25 fxs

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7
Q

NSABP B-06

Was there RT boost

A

No

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8
Q

NSABP B-06

Were LNs sampled?

A

For mastectomy, LNs removed en bloc

Axillary LNs remove for all

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9
Q

NSABP B-06

For +ve LNs, what was the course of action?

A

CHT w/ 5-FU and Melphalan

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10
Q

NSABP B-06

What were the end points?

A

Ipsilateral Breast Tumor Recurrence
Disease Free Survival
Overall Survival

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11
Q

NSABP B-06

IBTR @ 5 yrs?

A

Lump: 28%

Lump + RT: 8%

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12
Q

NSABP B-06

DSF @ 5 yrs?

A

Mast: 67%
Lump: 64%
Lump + RT: 71%

No Sig diff
Most frequent first event: Distant recurrence

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13
Q

NSABP B-06

OS @ 5 yrs?

A

Mast: 82%
Lump: 83%
Lump + RT: 84%

No sig diff

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14
Q

NSABP B-06

IBTR @ 20 yrs?

A

-ve nodes (P<0.001)
Lump: 39%
Lump + RT: 14%

+ve nodes (P<0.001)
Lump: 44.2%
Lump + RT: 18.2%

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15
Q

NSABP B-06

DSF @ 20 yrs?

A

Mast: 36%
Lump: 35%
Lump + RT: 35%

No sig diff

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16
Q

NSABP B-06

OS @ 20 yrs?

A

Mast: 47%
Lump: 46%
Lump + RT: 46%

No sig diff

17
Q

NSABP B-06

Main takeaways?

A

Mast and lumpectomy have similar OS and DFS @ 5 and 20 yrs

Lump + RT decreased IBTR by 2/3

18
Q

NSABP B-06

Important pt characteritics?

A 
60% women older than 50
62% w/ -ve LNs
50:50% small to large tumors
62% had -ve LNs
64 ER+: 36 ER-
19
Q

NSABP B-06

Timeline of IBTR

A

Majority within the first 5 yrs

Incidence decrease w/ time

Breast Cancer (9 decks)

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