Post-diuretics Case Study

Question 1

Diseases/defects that cause blockage of NaCl uptake in the TAL are called

Answer 1

Bartter syndrome

Question 2

what is the syndrome called that mimics the activity of thiazide diuretics?

Answer 2

gitelman’s syndrome

Question 3

what are defects in the CT ENaC channels that constitutively activate them called?

Answer 3

Liddle syndrome

Question 4

what is the biochemical basis for Liddle syndrome?

Answer 4

the deletion of a PY domain near the C terminus of the ENaC channel causes the channel to resist Ub regulated degradation (carried out by Nedd4-2)

Question 5

What is Gordon’s syndrome?

Answer 5

a defect in the WNK regulators of the NaCl transporter in the CT that causes hyperkalemia and hypertension

Question 6

what is the aldosterone paradox?

Answer 6

aldosterone is released to maintain potassium levels and to maintain ECF volume; how does it know which to do? possible answer - angiotensin II inhibits ROMK activation via WNK and activates proton channels and chloride channels to maintain electroneutrality