Portal HTN Flashcards
What is portal hypertension and why does it develop?
Because of increased resistance to portal blood flow through the liver causing high blood pressure in the portal system
What are the 3 categories of portal HTN?
Prehepatic
Intrahepatic
Posthepatic
Does the portal vein account for half, or 2/3rds of hepatic blood flow?
2/3rds
What is the strict definition of portal HTN?
absolute increase in the blood pressure within the portal vein > 8mmHg
OR
increase in the pressure gradient between the portal vein and hepatic vein of 5 mmHg or more
How is pressure in the portal vein assessed?
Doppler ultrasound
What are the major posthepatic causes of portal HTN?
Severe right-sided heart failure (and other causes of vena cavae obstruction)
Restrictive pericarditis
Budd-Chiari syndrome (thrombosis of the hepatic veins)
What Is the major intrahepatic cause of portal HTN?
Cirrhosis
What are the major causes of prehepatic portal HTN?
Thrombosis of the portal vein/splenic vein (due to hypercoaguable states and malignancy, eg pancreatic cancer)
Narrowing of the portal vein before it ramifies within the liver
Massive splenomegaly with increased splenic vein blood flow
What is the most important and frequent cause of portal HTN?
Cirrhosis
What are the minor causes of intrahepatic portal HTN?
Shistosomiasis (presinusoidal portal HTN)
Massive fatty change
Sarcoidosis (and other diffuse fibrosing granulomatous diseases)
Diseases affecting portal microcirculation (eg, nodular regenerative hyperplasia)
How is the resistance to portal flow increased at the level of the sinusoids in portal HTN?
Contraction of vascular smooth muscle and myofibroblasts
Disruption to normal flow by scarring and nodules of parenchymal regeneration
How do intrahepatic endothelial cells contribute to intrahepatic portal HTN?
Vasoconstrict through decrease in NO production
Release of endothelin-1, angiotensinogen and eicosanoids
How does the arterial system of the liver worsen intrahepatic portal HTN, especially in cirrhosis?
Arterial and portal systems in the liver anastamose
These intrahepatic shunts in fibrous septa load arterial pressure into the low pressure portal venous system
Also negatively affect metabolic exchange between sinusoidal blood and hepatocytes
How would you describe splanchnic circulation in portal HTN?
Hyperdynamic (fast flow rate)
Why does splanchnic circulation change in portal HTN?
NO production causing arterial vasodilation
Stimulated by reduced bacterial DNA clearance due to mononuclear phagocyte function decreasing
Also because of intrahepatic arterial-portal shunting bypassing Kupffer cell populations
Are antibiotics possibly effective in some treatments of portal HTN?
Yes
Bacteria are thought to contribute to splanchnic hyperdynamic flow
What are the four major complications of portal HTN?
Ascites
Formation of portosystemic shunts
Congestive splenomegaly
Hepatic encephalopathy
What is the term for accumulation of fluid in the peritoneal cavity?
Ascites
What percentage of ascites cases is caused by cirrhosis?
85%