Population Genetics

Question 1

Overview of linkage analyses (3)

Answer 1

• uses family data
• ID’s genes of large effect
• rare genes

Question 2

Overview of association studies (3)

Answer 2

• uses pop data
• find genes of small effect
• common genes

Question 3

What is a marker and what are 3 examples?

Answer 3

• any polymorphic trait we know something about
• RFLP
• VNTR
• SNP

Question 4

What are syntenic loci?

Answer 4

• on the same chromosome, but far enough apart that they assort ind

Question 5

Do you need to know the mode of inheritance in an association analysis?

Answer 5

No, b/c it’s population

Question 6

Other characteristics of association studies? (5)

Answer 6

• don’t use pedigree info
• cost effective
• can assess role of a candidate gene
• can’t determine effect size
• detect common variants of small effect

Question 7

5 assumptions of Hardy-Weinberg?

Answer 7

1. No mutation
2. No selection
3. Random mating
4. Infinite population
5. No migration

Question 8

How does autosomal dominant disorder incidence relate to allele freq?

Answer 8

Incidence of AD disorder = 2x allele freq

Question 9

Effect of inbreeding on the gene pool?

Answer 9

• increases rate of homozygeity

- no effect on allele freq’s