Population Genetics Flashcards
1
Q
cystic fibrosis has a heterozygous resistance to
A
typhoid fever
2
Q
hemochromatosis has a heterozygote advantage in
A
an iron-poor environment
3
Q
Glucose 6P dehydrogenase deficiency and the resulting hemolytic anemia has a heterozygote resistance to
A
malaria
4
Q
sickle cell disease has a heterozygous resistance to
A
malaria
5
Q
Siblings share what % of their genes
A
1/2 (50%)
6
Q
1st cousins share what percentage of their genes?
A
1/8
7
Q
2nd cousins share what percentage of their genes?
A
1/32
8
Q
Hardy-Weinberg equilibrium
A
- p(squared) + 2pq + q(squared) = 1
- p and q are the allele frequencies at a locus
- allows calculations of carrier frequency and prevalence of genetic disease
- For AR diseases:
- p (squared) = homozygous normal
- 2pq = heterozygous carrier
- q (squared) = homoqygous affected
- when calculating allele frequency, remember that p + q = 1
