Poon CNS Remediation #2

Question 1

SE of Phenytoin

Answer 1

• Nystagmus
• Somnolence
• Hirsutism
• Givigival hyperplasia

Question 2

SE of Valproic Acid

Answer 2

• Alopecia
• Weight gain
• Hepatotoxicity
• Teratogenic
• Thrombocytopenia

Question 3

SE of Topiramate

Answer 3

• Metabolic acidosis
• Oligohidrosis
• Nephrolithiasis
• Weight loss
• Memory/concentration problems

Question 4

Common Side Effects with SSRI

Answer 4

• GI (nausea, vomiting diarrhea)
• Insomnia
• Somnolence
• Headache
• Sexual Dysfunction
• Nervousness
• Restlessness

Question 5

Which SSRI has the longest half life?

Answer 5

PROZAC: fluoxetine

• Longest half life (acute 1-3 days, chronic 4-6 days)
• Active metabolite (Norfluoxetine- t1/2 of 4-16 days)
• Dosing range 20 mg-80mg/day
• Better adherence
• Comes in 90 mg weekly dose (do not use for new therapy)