Polyneuropathy Flashcards
Motor nerve neuropathy signs
LMN signs:
Weakness -> Distal > proximal
Muscle wasting
Hypotonia
Hyporeflexia
Downgoing plantars
Sensory nerve neuropathy signs
Reduced sensation
Paraesthesia
Pain
Sensory ataxia
Autonomic dysfunction
Postural hypotension
Abnormal sweating
Diarrhoea and constipation
Urinary retention
Causes of sensorimotor neuropathy
Diabetes
B12/folate deficiency
Alcohol
Hypothyroidism
Vasculitis
HSMN/Charcot-Marie-Tooth
Causes of motor neuropathy
CIDP (Chronic GBS)
GBS
Diabetic amyotrophy
Causes of sensory neuropathy
Paraneoplastic
Friederichs ataxia
Investigations of polyneuropathy
History + exam
Bloods -> B12, folate, U&E, LFTs, TFTs, ANA, ANCA, paraneoplastic antibodies
Neurophysiology -> EMG and nerve conduction studies
CT/PET CT for malignancy