polygenic disorders

Question 1

liability threshold

Answer 1

the more affected alleles a pt has the more likely they will be to develop the disease

Question 2

twin studies

Answer 2

use to determine environment vs genetic
twins are 1/100 births
Concordant: twins share the trait
discordant: twins dont share the trait

Correlation coefficient -1->1

Question 3

heritability

Answer 3

== 2 (concordance of monozygotic- concordance of dizygotic)

Question 4

adoption studies

Answer 4

see if the kid of an affected individual has the same issues in a different environment (adoption)O

Question 5

common varient hypothesis

Answer 5

common disease- common varient (CDCV): common disease causing (but low penetrance alleles or variants): will be found in all humans which manifest in a given disease

each varient at each gene influencing a complex disease will have a small effect on the disease phenotype

Question 6

linkage vs association studies

Answer 6

linkage look for relationship between inheritance of genetic marker and disease or trait within a family. the markers could be different for different families

association : look for a statistical relationship between the presence of a marker and a disease between families (in a larger population)