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Medicinal Chemistry I > Poll Everywhere Questions for Finals > Flashcards

Poll Everywhere Questions for Finals Flashcards

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1
Q

Which one of the electron transport complexes has enzyme activity which is directly shared with the Krebs cycle?
a. Complex I
b. Complex II
c. Complex III
d. Complex IV

A

b. complex II

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2
Q

Which electron transfer is NOT accompanied by the pumping of protons and the production of ATP?
a. Cytochrome c → O2 (oxygen) (complex IV)
b. NADH dehydrogenase (Complex I) → Q
c. Succinate dehydrogenase (Complex II) → Q
d. Q → Cytochrome c (complex III)

A

c. Succinate dehydrogenase (Complex II) → Q

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3
Q

How many protons are pumped by Complex IV when electrons are passed to one molecule of
oxygen?
a. 2
b. 4
c. 0
d. 8

A

b. 4

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4
Q

In Complex III electrons are passed:
a. NADH to Q
b. FADH2 to Q
c. Q to cytochrome c
d. cytochrome c to O2

A

c. Q to cytochrome c

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5
Q

Which of the statements regarding electron transport and oxidative phosphorylation is true?
a. The energy which promotes ADP phosphorylation is provided by a pH gradient.
b. The two processes usually occur independent of each other.
c. It is not possible to stop one process without stopping the other.
d. The ΔGo for ATP phosphorylation is inversely related to ΔEo

A

a. The energy which promotes ADP phosphorylation is provided by a pH gradient.

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6
Q

How many protons should translocate through ATPase in order to make 3 ATP molecules?
a. 6
b. 9
c. 3
d. 4

A

b. 9

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7
Q

Which uncoupler is relevant in newborns?
a. DNP
b. Thermogenin
c. Valinomycin
d. Rotenone

A

b. Thermogenin

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8
Q

Which of the following compounds inhibit ATP synthase?
a. Thermogenin
b. Rotenone
c. DNP
d. Oligomycin

A

d. Oligomycin

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9
Q

Which of the following is an uncoupling agent?
a. cyanide
b. rotenone
c. 2,4-dinitrophenol (DNP)
d. oligomycin
e. antimycin-A

A

c. 2,4-dinitrophenol (DNP)

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10
Q

Which of the following blocks electron transport?
a. Valinomycin
b. Thermogenin
c. 2,4-dinitrophenol (DNP)
d. CN-

A

d. CN-

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11
Q

Which of the following events can trigger apoptosis?
a. Pumping of protons to the interstitial mitochondrial space
b. Flow of protons back into the matrix of mitochondria
c. Flow of electrons from Q to cytochrome c
d. Permeabilization of outer membrane of mitochondria with release of cytochrome c into
cytoplasm

A

d. Permeabilization of outer membrane of mitochondria with release of cytochrome c into
cytoplasm

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12
Q

Which of the following is not specifically required in the synthesis of fatty acids?
a. Biotin
b. AcetylCoA
c. malonylCoA
d. Malate
e. CO2 (HCO3-)

A

d. Malate

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13
Q

Which of the following is not true of the reaction in which malonyl-CoA is produced during fatty acid
synthesis?
a. It requires CO2 (or bicarbonate).
b. The cofactor is biotin.
c. It requires acyl carrier protein (ACP).
d. It is stimulated by citrate.

A

d. It is stimulated by citrate

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14
Q

Which of the following is a component of acyl carrier protein (ACP)?
a. Pantothenic acid
b. Pyridoxine
c. Biotin
d. Cobalamine (?)

A

a. Pantothenic acid

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15
Q

Acetyl CoA for fatty acid synthesis is generated by:
a. acetyl CoA synthase
b. citrate lyase
c. carnitine acyltransferase
d. pyruvate dehydrogenase

A

b. citrate lyase

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16
Q

Fatty acid synthesis is inhibited by:
a. insulin
b. palmitoyl-CoA
c. citrate
d. pyruvate

A

b. palmitoyl-CoA

17
Q

Atherosclerosis and Coronary Heart Disease is associated with
a. Low Triglycerides
b. Low LDL
c. Low VLDL
d. Low HDL

A

d. Low HDL

18
Q

Which of the following lipoproteins contains the greatest amount of cholesterol?
a. chylomicrons
b. VLDL
c. HDL
d. LDL

A

d. LDL

19
Q

Pioglitazone (Actos®)
a. is a thiazolidinedione (TZD)
b. increases PEPCK
c. is an insulin sensitizer
d. All of the above

A

d. All of the above

20
Q

Match the drugs with their mechanism of action. Inhibits HMG-CoA reductase:
a. NSAIDs
b. TZDs
c. Celecoxib (Celebrex)
d. Lovastatin (Mevacor)

A

d. Lovastatin (Mevacor)

21
Q

The glutamine biosynthesis form glutamate involves:
a. Glutamine synthetase
b. ATP
c. NH4+
d. Glutamate
e. All of the above

A

e. All of the above

22
Q

Which of the following compounds is not a metabolic precursor of amino acids?
a. 3-phosphoglycerate
b. Oxaloacetate
c. Pyruvate
d. 𝛼-ketoglutarate
e. Glucose-6-phosphate

A

e. Glucose-6-phosphate

23
Q

A decarboxylase is not involved in the biosynthesis of?
a. Dopamine
b. Serotonin
c. GABA
d. Histamine
e. Glutamine

A

e. Glutamine

24
Q

D-aminolevulinic acid is formed from succinyl-CoA and ______________ as an intermediate in the biosynthesis of _____________.
a. Serine; sphingosine
b. Serine; heme
c. Glycine; porphyrins
d. Acetyl-CoA; long chain fatty acids

A

c. Glycine; porphyrins

25
Q

Jaundice is the accumulation of?
a. Heme
b. Bilirubin
c. Biliverdin
d. UDPGT

A

b. Bilirubin

26
Q

Biosynthesis of purines can be blocked by?
a. Febuxostat
b. 6-thioguanine
c. Phototherapy
d. 5-FU

A

b. 6-thioguanine

27
Q

Cancer growth can be inhibited through the use of?
a. 5-flurouracil
b. Aspirin
c. Statins
d. Febuxostat
e. Uricase

A

a. 5-flurouracil (5FU)

28
Q

Which statement is true regarding gout?
a. It can be controlled by inhibiting xanthine oxidase
b. It can be caused by an over activity of the enzyme HGPRT
c. It is associated with over excretion of uric acid
d. It is associated with the over production of urea

A

a. It can be controlled by inhibiting xanthine oxidase

29
Q

Which is used in the treatment of diabetes?
a. Sitagliptin (Januvia)
b. Allopurinol (Zyloprim)
c. Celecoxib (Celebrex)
d. Lovastatin (Mevacor)

A

a. Sitagliptin (Januvia)

30
Q

In May 2011, the FDA approved a new drug, Linagliptin (Tradjenta) which is similar to Sitagliptin (Januvia) and thus works because?
a. It is an analog of amylin
b. It is long acting insulin
c. It is a DPP IV inhibitor, an incretin enhancer
d. It is a synthetic GLP-1 molecule

A

c. It is a DPP IV inhibitor, an incretin enhancer

31
Q

Which of the following is true?
a. Insulin is secreted from beta cells when calcium influx occurs
b. Insulin is stored with amylin is secretory glands
c. High ATP levels increase insulin release in pancreatic beta cells
d. All of the above

A

d. All of the above

32
Q

Which insulin is long acting?
a. Aspart Insulin (Novolog)
b. Lispro insulin (Humalog)
c. Insulin Glulisine (Apidra)
d. Glargine Insulin (Lantus)

A

d. Glargine Insulin (Lantus)

33
Q

Which of the following statements regarding amylin is false?
a. It is stored in insulin granules
b. It does not affect glucagon secretion
c. It slows gastric emptying
d. It is secreted with insulin

A

b. It does not affect glucagon secretion

34
Q

Which statement is false?
a. The brain utilizes ketone bodies during starvation
b. Much of the energy used in the brain is for action potentials
c. In the well-fed state, glucose supplies energy substrates for the brain
d. The brain stores large amounts of glycogen

A

d. The brain stores large amounts of glycogen

35
Q

Which of the following statement is false with regard to the nutritional quality of proteins?
a. Animal protein is of higher quality than plant protein
b. The biologic value will not decrease substantially if a protein lacks only one amino acid
c. Combinations of plant and animal protein can provide all the amino acids in a diet
d. Human milk has high biological value

A

b. The biologic value will not decrease substantially if a protein lacks only one amino acid

36
Q

Approximately what percent of the diet should come from protein?
a. 24
b. 12
c. 48
d. 6

A

b. 12

37
Q

The average caloric content of proteins (Kcal/g) is?
a. 4
b. 6
c. 9
d. 12

A

a. 4

38
Q

How many protons can relocate from NADH? ATP?

A

10 ( 3 ATP)

39
Q

How many protons can relocate from FADH2? ATP?

A

6 ( 2 ATP)

Medicinal Chemistry I (2 decks)

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