Point of Care Flashcards
What does point of care testing mean
Medical testing at or near the site of patient care
What do POC technologies focus on
- Diagnostics - e.g: cardiac biomarkers (Troponin) & detection of infectious agents (COVID)
- Monitoring - e.g: blood glucose, blood gas analysis
- Screening - e.g: drug abuse, pregnancy, infectious agents (COVID)
What can technology be classified as
- Professional testing
- Non professional testing
Broad types of technology that support professional POC (2)
- Small bench top analysers
- Hand held devices
What is essential for quality care for small bench top analysers
- Appt. IT support / connectivity to main lab systems (LIMS)
What are the dominant technologies in hand held devices (2)
- Biosensor strips
- Lateral flow strips
Features common to all users in all settings
- Simple to use
- Reagents sturdy in storage & usage
- Results need to be comparable to established lab methods
- Devices & reagents safe to use
- Portability
- Fast throughput
- Cost
- IT connectivity capability
positives & negatives of portable devices using fingerstick/capillary samples
pos: no separate container or transport needs
negs: H&S risks - designed to minimise risk (training & documentation)
Bench top analyser - GEM 4000 - what analytes can it run
- Blood gases
- Electrolytes
- Glucose
- Urea
- Bilirubin
- Hb derivatives
What is one of the advantages of GEM 4000 critical care analyser
Micro sample volumes direct from capillary/syringe (patient may be in critical condition)
Principle of roche cobas liat system
Fully automated PCR system that detects single targets
What are immunostrips based on
The use of immunosensors (Ag:Ab) (Ab detecting system)
Features of immunostrips
- Can be based on different formats - e.g: lateral flow
- In build QC - control vs test
- Can be qualitative & quantitative
- Analytical performance must be defined by the manufacturers
Hb levels for donor eligibility
Male: greater than 13.5 g/dL
Female: greater than 12.5 g/dL
POC devices in blood donation centers
- Hb measurement prior to donation
- Fast screening system
- Invasive (risk associated- e.g: finger prick) or noninvasive techs (e.g: pulsometer)
- High levels accuracy & precision essential
Requirements of POC in clinical settings & patient management
- SOPs needed for every POC device
- Appt. training & competency assessment of operating staff is essential
- QMS models to review & monitor all aspects of POC
- Can achieve standardisation via ISO standards 22870
- Integrated IT systems NB
- Success based on multi descipline operation & effective communication
