PNS Receptors Flashcards
M2
Tissue
Response
Mechanism
Tissue - heart and axon terminals (auto receptors)
Response - decreases HR, conduction velocity, and contractility (opposite of beta 1 and 2).
Mechanism - Gi, increased K efflux, decreased Ca influx
M3 Tissues of action
Smooth muscle, secretory glands, and vascular endothelium
M3 action on smooth muscle
Types of smooth muscle
Response
Mechanism
Eye, bronchioles, GI tract, urogenital system
Response - contraction
Mechanism - Gq
M3 action on secretory glands
Response
Mechanism
Response - increased secretion
Mechanism - Gq
M3 action on vascular endothelium
Response
Mechanism
Response - vasodilation
Mechanism - Ca++/CaM activates eNOS → ↑ NO → ↑ cGMP → relaxation
Nm
Tissue
Response
Mechanism
Tissue - NMJ
Response - skeletal muscle contraction
Mechanism - Na/K channel opens –> depolarization
Nn tissues of action
Atuonomic ganglia and adrenal medulla
Nn action on autonomic ganglia
Response
Mechanism
Response - depolarizes postsynaptic neurons
Mechanism - opens Na/K pump –> depolarization
Nn action on adrenal medulla
Response
Mechanism
Response - depolarizes medullary cells –> secretion of catecholamines
Mechanism - opens Na/K pump –> depolarization
Alpha 1 tissues of action
smooth muscle (eye, vascular, urogenital, and hair follicles), and liver
Alpha 1 action on smooth muscle
Types
Response
Mechanism
eye, vascular, urogenital, hair follicles
Response - contracts smooth muscle
Mechanism - Gq
Alpha 1 action on liver
Response
Mechanism
Response - increased glycogenolysis and gluconeogenesis
Mechanism - Gq
Alpha 2 tissues of action
Axon terminals (autoreceptors), pancreatic beta cells, vascular smooth muscle, platelets
Alpha 2 action on axon terminals
Response
Mechanism
Response - decreased NE release
Mechanism - Gi and Gq. ↓ AC → ↓ cAMP; ↑ K+ channel efflux; ↓ L- and N-type Ca++ channel influx; ↑ PLC → ↑ IP3, DAG, Ca++
Alpha 2 action on pancreatic beta cells
Response
Mechanism
Response - decreased insulin release
Mechanism - Gi and Gq. ↓ AC → ↓ cAMP; ↑ K+ channel efflux; ↓ L- and N-type Ca++ channel influx; ↑ PLC → ↑ IP3, DAG, Ca++
Alpha 2 action on vascular smooth muscle
Response
Mechanism
Response - contracts smooth muscle
Mechanism - Gi and Gq. ↓ AC → ↓ cAMP; ↑ K+ channel efflux; ↓ L- and N-type Ca++ channel influx; ↑ PLC → ↑ IP3, DAG, Ca++