PNB Exam 3 Flashcards
excitable cells
cells that recive and send electrical signals across plasma membrane
electrophysiology
Originally called Galvanism, the study of excitability
K+
higher concentration in the cell
Na+
Higher concentration outside of the cell
Cl
Higher concentration outside of cell
Ca
Higher concentration outside of the cell
Concdntration Gradient
Gradient = [Ion]
outisde
− [Ion]
inside
Voltage-gated ion channels
ated by changes in the relative distribution of charges in their local environment. Any positive or negative change is “sensed” by charged amino acid residues in the channel protein, causing a change in conformation
Ligand-gated ion channels
gated by a chemical messenger (a ligand) that binds to the channel on the inside or outside of the cell (Figure 8.3b). These channels contain a binding site for a hormone or neurotransmitter
ion channels only allow passive transport of ions.
relative concentration gradients never change because of the large cytoplasmic volume.
by what process is sodium moved out of the cell?
Active transport
ions are charged particles, their movement is influenced
by their concentration gradient, but also by electrostatic forces
membrane potential
difference in charge between the two environments creates a form of potential energy, stored eneger
electrochemical equilibrium,
Eventually, however, the entry of Na+ would be slowed and stopped by like-charge repulsion arising from the accumulation of positive charges inside the cell