Pleural and Peritoneal Flashcards
1
Q
A
2
Q
What are histopathologic features of mesothelial cells?
What markers do they stain for?
What markers do we stain to identify mesothelioma?
A
Mesos can come in well-spaced sheets with intercellular windows or float around as individual cells with large nuclei, abundant cytoplasm, eccentrically placed nucleoli, and skirts. They can also become floridly reactive and even multi-nucleated in inflammatory conditions.
They stain for calretinin, WT1, and A1/AE3 (they express some keratins, but not as many as epithelial cells).
In mesothelioma, you will commonly find a LOSS of one of the following: NF2, BAP1, MTAP. However, there are plenty of mesotheliomas out there where these are all retained, so don’t rely too much on these.
