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HEMA II > Platelets week 2-3 > Flashcards

Platelets week 2-3 Flashcards

1
Q

Stages in megakaryopoiesis

A

Megakaryoblast
Promegakaryocyte
Megakaryocyte
Metamegakaryocyte

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2
Q

Substructures in peripheral zone

A

Glycocalyx
Platelet membrane
Open canalicular system
Submembrane region

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3
Q

Hemostasis involved with clot formation

A

Secondary hemostasis

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4
Q

Steps in platelet plug formation

A 
Platelet Adhesion
Platelet shape change
Platelet aggregation
Platelet release reaction
Platelet plug stabilization
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5
Q

Factors inhibiting Platelet activity

A 
Heparin sulfate
thrombomodulin
CD 39
Nitric oxide
prostacyclin
13- HODE
t-PA
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6
Q

Most important GF for platelet production

A

thrombopoietin

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7
Q

NC ratio in promegakaryocyte

A

1:1

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8
Q

Distinguishing feature of megakaryoblast

A

DMS

0.2 um vacuoles in electron microscope

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9
Q

at which stage is protrusions present

A

Megakaryoblast and promegakaryocyte

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10
Q

Megakaryocyte is mistaken for?

A

Reed-sternberg cell

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11
Q

T or F:

Megakaryocyte can produce platelets because it has 2-3 nuclei

A

False; metamegakaryocyte kaya mag produce

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12
Q

Difference of granules in megakaryocyte and metamegakaryocyte

A

Megakaryocyte granules are reddish blue and has equal distribution

Metamegakaryocyte granules are scattered, aggregated, and clumped

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13
Q

how many percent of platelets is present in spleen

A

30%

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14
Q

T or F:

Platelets are anucleated cell without golgi bodies, RER, and mitochondria

A

False; meron mitochondria

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15
Q

Amorphous coat that surrounds the platelet

A

Glycocalyx

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16
Q

Canal of passage of different component which facilitates interaction intracellularly and extracellularly

A

Open canalicular system

17
Q

Maintains the discoid shape of platelets

A

Microtubules

18
Q

Granules in alpha

A 
BTG
PDGF
Thrombospondin
PF 4
Fibrinogen
Factor V and VIII
vWF
Fibronectin
Albumin
HMWK
Plasminogen
19
Q

In alpha granules which is important in clotting

A

PF4

Thrombospondin

20
Q

T or F:

Platelets should be intact, brittle and flexible

A

False; Not brittle

21
Q

Process which traps the blood or control the escape of blood

22
Q

What type of collagen is found in tunica media? in endothelial cells

A

media - Collagen II and III

Adventitia - Collagen IV and V

23
Q

action of CD39

A

Converts ADP to AMP

24
Q

Counter part of thromboxane A2

A

Prostacyclin

25
Q

T or F:

all coagulation factors are produced in the liver

A

False; except vWF

26
Q

Disease wherein there is inability of platelets to adhere on the vessel

A

Bernard solier syndrome

HEMA II (1 decks)

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