PLATELET PRODUCTION, STRUCTURE AND FUNCTION Flashcards
Platelet is ______ cells that circulate at a conc. of ________
Non nucleated
150-400x10^9/L
Platelet count is slight higher in ___ than in ____
Women
Men
Platelet count is slightly lower at the age older than
65 years
Primary hemostasis involves ______
Platelets
Secondary hemostasis involves ____
Coagulation factor
Tertiary hemostasis involves ___
Fibrinolysis
3 types of hemostasis
Primary
Secondary
Tertiary
Platelets arise from what cell
Megakaryocyte (MK III)
1 MK III can create ____ platelets
2000 - 4000 platelets
Increase platelets results to
Thrombosis
Decrease platelets results to
Bleeding
Largest cells of BM
Megakaryocyte
MK III possess multiple chromosome copies called
Polypoid
Size of normal MK III in diameter
30 - 50 um
MK III accound for _____ % of all BM cells
0.5 %
Cell line where cells become bigger as they mature
MK III
MK III do not undergo mitosis but instead it under go ___
endomitosis
Common progenitor of platelets
Common Myeloid Progenitor
3 stages of platelet production
Proliferative stage
Terminal Differentiation stage
Thrombopoiesis stage
3 MG Progenitors
Burst Forming Unit - Megakaryocyte (BFU-Meg)
Colony Forming Unit - Megakaryocyte (CFU- Meg)
Light Density - Colony Forming Unit - Megakaryocyte (LD-CFU-Meg)
MK I
Megakaryoblast
MK II
Promegakaryocyte
MK III
Megakaryocte
Cells under Terminal Differentiation Stage
Megakaryoblast
Promegakaryocyte
Megakaryocyte
Stage where in the MK III to Platelet process happen
Thrombopoiesis stage
