Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Hematology 2 > Platelet - notes > Flashcards

Platelet - notes Flashcards

1
Q

It consist of a granulr cytoplasm with a membrane but without nucleus

A

PLATELETS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Shape of platelets in a wright-stained Peripheral blood smear

A

Biconvex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the Mean Platelet Volume of platelets

A

8-10 femto liter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the normal value of platelets in human body?

A

150-400 x 10^9/L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

It can be available in times of Acute Inflammation, After an injury, Major surgery, and Plateletpheresis

A

Sequestered platelet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

TRUE or FALSE

Plateles flows smoothly in blood vessel wall.

A

TRUE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

TRUE or FALSE

Platelets move laterally with the red blood cells in the white pulp of the spleen.

A

FALSE!!!! It moves laterally with the WHITE BLOOD CELLS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

It is also called “stress platelets”

A

Reticulated platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

It appear in compensation for thrombocytopenia

A

Reticulated Platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

It appears cylindrical, beaded, and resembles fragments of megakaryocyte proplatelet process in a citrated whole blood

A

Reticulated plateles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

It carries free ribosomes and fragments of rough ER

A

Reticulated platelets/stress platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In stress platelets, what is the nucleic dye that binds the RNA of the ER

A

Thiazole Orange

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

It is used to visualize stress cells microscopically

A

Thiazole Orange

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

It provides quantitative evaluation of reticulated platelet production under stress

A

Thiazole Orange

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the most commonly used laser-based technology to study the ultrastructure of platelets?

A

Flow Cytometry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

It is composed of 60% protein, 30% lipid, 8% carbs, various materials, water and nucleotides

A

PLATELET

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the four anatomical areas of platelets?

A

Peripheral zone
Sol-gel zone
Organelle zone
Membranous zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

It is reponsible for adhesion and aggregation

A

Peripheral zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Anatomical area of a platelet that is composed of microfilaments and microtubules

A

Sol-gel Zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Anatomical area of the platelet that is composed of Alpha and Dense granules, mitochondria, and lysosomal granules

A

Organelle zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

In the membranous zone of platelets, where is the site for arachidonic acid metabolism?

A

Dense tubular System

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

It is a part of the membranous zone that twists spongelike throughout the platelet, enabling the platelet to store additional quantities of the same hemostatic protein

A

Surface connected canalicular system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

It is a selectively permeable bilayer composed of proteins and lipids

A

Platelet plasma membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are the predominant lipids found in the plasma membrane of platelets?

A

PHOSPHOLIPIDS & CHOLESTEROL

Phospholipids forms the basic stricture

Cholesterol stabilizes the membrane, maintain fluidity, helps control the transmembranous passage of materials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Phospholipids that is predominant in the plasma layer
Neutral phospholipids
26
Phospholipids that is predominant in the inner cytoplasmic layer
Anionic or Polar phospholipids
27
Phospholipid surface on which coagulation enzymes assembles and flips to the outer surface on activation
Phosphatidylethanolamine
28
It is anchored on the platelets plasma membrane that supports surface glycosaminoglycans, oligosaccharide and glycolipids
Glycoprotein and Proteoglycans
29
What are the neutral phospholipids in the platelets plasma mambrane
Phosphatidylcholine and Sphingomyelin
30
It controls the center for PLATELET ACTIVATION and sequesters Calcium and bears series of enzymes
Dense Tubular System
31
What are the enzymes that support platelet activation?
- phospholipas A2 - cyclooxygenase - thromboxane synthetase - phospholipase C
32
It inhibits cyclooxygenase
ASPIRIN :)
33
Enzyme that supports the production of inositol triphosphate (IP3)
Phospholipase C
34
Maintains the platelet’s shape
Circumferential microtubules
35
Connect with actin and tubules to maintain shape of platelets
Intermediate Filaments (Desmin and Vementin)
36
Other name of actomyosin
Thrombosthenin
37
What is the tube used for clot retraction time
Red top
38
It detects the contraction of thrombosthenin
Clot Retraction Time (CRT)
39
Platelet granules that stain medium gray in TEM
Apha granules
40
What is the dye used to stain alpha granules
Osmium dye
41
TRUE or FALSE Alpha granules is filled with proteins.
TRUE and proteins in alpha granules can be: 1. ENDOCYTOSED 2. STORED IN PLATELETS 3. SYNTHESIZED IN MEGAKARYOCYTE
42
Platelet granules which contents flow in the NEARBY ENVIRONMENT
Alpha granules
43
Roles of alpha granules in platelet
1. Adhesion 2. Aggregation 3. Plasma coagulation
44
Platelet granule that release their contents DIRECTLY INTO THE PLASMA upon activation
Dense Granules
45
Normal Value of ALPHA GRANULES per platelet
50-80 per platelet
46
Normal value of dense granules per platelet
2-7 per platelet
47
It digest vessel wall matrix components during in vivo aggregation and may also digest autophagic debris
Lysosomes of platelets
48
Enzymes that stain positive in platelets
Beta glucoronidase Arylsulfatase Catalase Acid phosphatase BACA!!!! BACA!!!! BACA!!!!
49
Stoppage of blood flow
Hemostasis
50
What are the four phses of platelet function
Platelet Adhesion Platelet Activation Platelet secretion Platelet aggregation
51
It is the process where platelets stick to foreign surface receptors.
Platelet Adhesion
52
Absence of Gp1b will lead to what syndrome
BSS - Bernard Souller Syndrome (characterized by giant platelets)
53
This is a substance that stimulate platelet activation
Agonist (ex. Arachidonic acid)
54
It stimulates platelet secretion and serves as vasoconstrictor
Thromboxane A2
55
Phase of platelet function where platelets release the content of their granules
Platelet secretion
56
It is the attachment of platelets to each other that requires fibrinogen and calcium
Platelet aggregation
57
Absence of gpIIb/IIIa will lead to what platelet abnormality
Glanzmann Thrombasthenia
58
It controls cellular activation for all cells
G proteins
59
It binds guanosine diphosphate when inactive
Alpha-beta-gamma heterodimers
60
It decelerates Adenylate cyclase
G1
61
It Activates phospholipase C
Gg
62
It activates protein kinase C
G12
63
It accelerates Adenylate cyclase
Gs

Hematology 2 (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions