Platelet Function

Question 1

What are platelet derived growth factors?

Answer 1

Platelet derived growth factors (PDGFs) are a group of proteins that regulate cell growth and division.

Question 2

True or False: PDGFs are only involved in wound healing.

Answer 2

False: PDGFs are involved in various biological processes including development, healing, and disease.

Question 3

Fill in the blank: PDGFs play a critical role in __________ repair and regeneration.

Answer 3

tissue

Question 4

What is the primary source of PDGFs in the body?

Answer 4

Platelets

Question 5

Multiple choice: Which of the following is a type of PDGF? A) PDGF-A B) PDGF-B C) Both A and B

Answer 5

C) Both A and B

Question 6

What is the role of PDGF in the healing process?

Answer 6

PDGF stimulates cell proliferation and migration, aiding in tissue repair.

Question 7

True or False: PDGF is only active in the presence of platelets.

Answer 7

False: PDGF can act on various cells and tissues even when platelets are not present.

Question 8

Fill in the blank: PDGF binds to specific receptors on the surface of __________.

Answer 8

target cells

Question 9

What are the two main receptor types for PDGF?

Answer 9

PDGFR-α and PDGFR-β

Question 10

Multiple choice: Which of the following processes does PDGF NOT influence? A) Cell growth B) Inflammation C) Blood clotting

Answer 10

C) Blood clotting

Question 11

What is a significant pathological role of PDGF?

Answer 11

PDGF is implicated in the development of certain cancers and fibrotic diseases.

Question 12

True or False: PDGF can promote angiogenesis.

Answer 12

True

Question 13

Fill in the blank: PDGF is secreted by __________ during the early stages of wound healing.

Answer 13

platelets

Question 14

What effect does PDGF have on smooth muscle cells?

Answer 14

PDGF stimulates proliferation and migration of smooth muscle cells.

Question 15

Multiple choice: PDGF is involved in which type of cellular response? A) Apoptosis B) Proliferation C) Differentiation

Answer 15

B) Proliferation

Question 16

What is the mechanism of action for PDGF?

Answer 16

PDGF binds to its receptors, activating signaling pathways that lead to cell division and migration.

Question 17

True or False: PDGF can enhance the immune response.

Answer 17

True

Question 18

Fill in the blank: The main function of PDGF is to promote __________.

Answer 18

cellular growth

Question 19

What is the relationship between PDGF and fibroblasts?

Answer 19

PDGF stimulates fibroblast proliferation and collagen synthesis.

Question 20

Multiple choice: PDGF is primarily produced in response to which of the following? A) Injury B) Infection C) Stress

Answer 20

A) Injury

Question 21

What is the effect of PDGF on endothelial cells?

Answer 21

PDGF promotes migration and proliferation of endothelial cells, aiding in new blood vessel formation.

Question 22

True or False: PDGF has no role in chronic inflammatory diseases.

Answer 22

False: PDGF is involved in the pathogenesis of chronic inflammatory diseases.

Question 23

Fill in the blank: PDGF is considered a __________ factor due to its role in cell signaling.

Answer 23

growth

Question 24

What role does PDGF play in atherosclerosis?

Answer 24

PDGF contributes to the proliferation of smooth muscle cells in arterial walls.

Question 25

Multiple choice: PDGF can be used therapeutically in which of the following? A) Cancer treatment B) Bone healing C) Both A and B

Answer 25

C) Both A and B