Platelet Function Flashcards
What are platelet derived growth factors?
Platelet derived growth factors (PDGFs) are a group of proteins that regulate cell growth and division.
True or False: PDGFs are only involved in wound healing.
False: PDGFs are involved in various biological processes including development, healing, and disease.
Fill in the blank: PDGFs play a critical role in __________ repair and regeneration.
tissue
What is the primary source of PDGFs in the body?
Platelets
Multiple choice: Which of the following is a type of PDGF? A) PDGF-A B) PDGF-B C) Both A and B
C) Both A and B
What is the role of PDGF in the healing process?
PDGF stimulates cell proliferation and migration, aiding in tissue repair.
True or False: PDGF is only active in the presence of platelets.
False: PDGF can act on various cells and tissues even when platelets are not present.
Fill in the blank: PDGF binds to specific receptors on the surface of __________.
target cells
What are the two main receptor types for PDGF?
PDGFR-α and PDGFR-β
Multiple choice: Which of the following processes does PDGF NOT influence? A) Cell growth B) Inflammation C) Blood clotting
C) Blood clotting
What is a significant pathological role of PDGF?
PDGF is implicated in the development of certain cancers and fibrotic diseases.
True or False: PDGF can promote angiogenesis.
True
Fill in the blank: PDGF is secreted by __________ during the early stages of wound healing.
platelets
What effect does PDGF have on smooth muscle cells?
PDGF stimulates proliferation and migration of smooth muscle cells.
Multiple choice: PDGF is involved in which type of cellular response? A) Apoptosis B) Proliferation C) Differentiation
B) Proliferation
What is the mechanism of action for PDGF?
PDGF binds to its receptors, activating signaling pathways that lead to cell division and migration.
True or False: PDGF can enhance the immune response.
True
Fill in the blank: The main function of PDGF is to promote __________.
cellular growth
What is the relationship between PDGF and fibroblasts?
PDGF stimulates fibroblast proliferation and collagen synthesis.
Multiple choice: PDGF is primarily produced in response to which of the following? A) Injury B) Infection C) Stress
A) Injury
What is the effect of PDGF on endothelial cells?
PDGF promotes migration and proliferation of endothelial cells, aiding in new blood vessel formation.
True or False: PDGF has no role in chronic inflammatory diseases.
False: PDGF is involved in the pathogenesis of chronic inflammatory diseases.
Fill in the blank: PDGF is considered a __________ factor due to its role in cell signaling.
growth
What role does PDGF play in atherosclerosis?
PDGF contributes to the proliferation of smooth muscle cells in arterial walls.
Multiple choice: PDGF can be used therapeutically in which of the following? A) Cancer treatment B) Bone healing C) Both A and B
C) Both A and B
