Plasticity: Inhibitory Synapses

Question 1

Inhibitory synapses release____ and ____

Answer 1

GABA and Glycine

Question 2

GABA can inhibit…

Answer 2

GABA can inhibit AP firing in neurons

Question 3

GABA is found in….

Answer 3

GABA is found in interneurons

Question 4

Predominant precursor for GABA is ____ which is metabolised into _____ by _____

Answer 4

Predominant precursor for GABA is Glucose which is metabolised into Glutamate by GAD (glutamic acid decarboxylase)

Question 5

GAD requires pyridoxal phosphate which is derived from _____. Lack of this leads to reduced GABA syynthesis

Answer 5

Vitamin B6

Question 6

___ and ___ can also act as GABA precursors

Answer 6

Pyruvate and Glutamine

Question 7

With reduced/loss of GABA you have loss of ______, which can cause___

Answer 7

With reduced/loss of GABA you have loss of Synaptic inhibition, which can cuase seizures

Question 8

Most GABA is converted into_____

Answer 8

Succinate, which is metabolized in the triboxylic acid cycle

Question 9

There are 3 GABA postsynaptic receptors:

Answer 9

GABAa, GABAb, GABAc
Inotropic: a & c
Metabotropic: b

Question 10

The Ion conductant in GABA receptor is:

Answer 10

Cl-

Question 11

Drugs that act as agonists of postsynaptic GABA receptors (Bensodiazepines) can treat?

Answer 11

Epilepsy, and are effective sedatives and anesthetics

Question 12

What can alter the activity of GABA receptors?

Answer 12

Alcohol

Question 13

About half the inhibitory synapses use GABA or Glycine

Answer 13

Glycine

Question 14

Glycine can be synthesised by the precursor ____

Answer 14

Serine

Question 15

If Glycine is not removed due to mutaitons in transporters, this can result in ?

Answer 15

Hyperglycinemia: seizures, mental retardation, lethargy

Question 16

What type of receptor is Glycine?

Answer 16

Inotropic??