Plasticity and Functional Recovery of the Brain After Trauma Flashcards

1
Q

What is plasticity?

A

The apparent ability of the brain to change and adapt its structures and processes as a result of experience and new learning. ​

Researchers used to believe that changes in the brain only happen in infancy/childhood, but more recent research has demonstrated that the brain continues to create new neural pathways and alter existing ones to adapt to new experiences as a result of learning.​

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2
Q

Outline Machin’s study from 2018.

(Supports the idea that the brain can change in adulthood)

A

Supports the idea that the brain can change in adulthood.

This is because they found that when men become fathers, their brain changes as a result.

The areas associated with planning and problem solving (in the cortex) become more active, and in the unconscious brain we see changes in areas related to risk-assessment and nurturing.

This suggests that brain plasticity can change as a result of paternity.

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3
Q

How does plasticity link to functional recovery?

A

The way certain abilities of the brain may be moved or redistributed rather than lost following damage or trauma to the brain.

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4
Q

State 3 ways in which the brain can be injured?

A

Traffic accidents, assaults, or falls.

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5
Q

Do all recover from brain injuries?

A

Almost all people who suffer brain injury can make some recovery but the extent of this depends on the trauma itself and subsequent care of the patient.

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6
Q

How does the brain recover from injury?

A

New branches of axons and dendrites need to grow within neurons, but in some cases the brain adapts to the trauma and finds another way to complete a function. ​

Recovery is not always complete and depends on the level and type of damage.

E.g. the size of the stroke/the part of the brain infarcted - deprived of oxygen - therefore resulting in tissue death.

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7
Q

Outline Maguire et al’s study from 2000.

(Supports the idea of brain plasticity)
(AO3 Brain Plasticity Research)

A

Supports the idea of brain plasticity.

This is because they found that there was a significantly greater volume of grey matter in the posterior hippocampus of taxi drivers, than in a matched control group. ​

Drivers have to undertake intense training and take a test called “The Knowledge” which assesses their recall of city streets and possible routes; this learning experience may have altered the structure of the taxi drivers’ brains.

There was also a positive correlation between time in job and the pronouncement of the structural differences (denser grey matter in hippocampus).

This suggests that brain plasticity can occur, even in adulthood.

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8
Q

Outline Draganski et al’s study from 2006.

(Supports the idea of brain plasticity)
(AO3 Brain Plasticity Research)

A

Supports the idea of brain plasticity.

This is because they imaged the brains of medical students 3 months prior to and after their final exams.

Learning-induced changes were seen to have occurred in the same location (posterior hippocampus) and also the parietal cortex, presumable as a result of learning for their exams. ​

This reinforces Maguire et al’s taxi study.

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9
Q

Outline Mechelli et al’s study from 2004.

(Supports the idea of brain plasticity)
(AO3 Brain Plasticity Research)

A

Supports the idea of brain plasticity.

This is because they found a larger parietal cortex in the brains of people who were bilingual compared to matched monolingual controls. ​

This suggests that greater linguistical knowledge can alter brain structure.

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10
Q

Outline Kuhn et al’s study from 2014.

(Supports the idea of brain plasticity)
(AO3 Brain Plasticity Research)

A

Supports the idea of brain plasticity.

This is because they found that when PPs played Super Mario for at least 30 minutes per day over a 2-month period, (compared their brain development to a control group who were not playing video games), there were significant differences in grey matter of the video-gaming participants, particularly in the cortex, hippocampus and cerebellum.

These improved spatial navigation, strategic planning, working memory and motor performance.​

This suggests that by engaging in video games, the brain can positively develop.

This study also has wider implications, as it suggests video games as a form of rehab.

It could be used to counteract known risk factors for mental disease such as smaller hippocampus and prefrontal cortex - in e.g. schizophrenics.

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11
Q

What is functional recovery?

A

Much recovery after trauma is due to anatomical compensation, brought about by intensive rehabilitation. ​

The brain learns to compensate for function.

The brain can be taught how to use the working areas, to compensate the ones that are potentially lost forever.

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12
Q

Outline the case study of Scotty Cranmer.

A

BMX rider who suffered a major brain and spinal cord injury.

He managed to recover as:

Rehab was quick intensive.
Motivated to get back to his past position in life.
Passionate about what he did with his life, so taking that way meant that we did have a focus to have a goal to get back to where he was.

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13
Q

What happens in the brain during recovery?

A

Our brain is able to rewire and reorganise itself by forming new synaptic connections close to the area of damage.

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14
Q

What did Doidge state in 2007.

A

State that secondary neural pathways that would not typically be used to carry out a function are activated or “unmasked” to enable functioning to continue, often in the same way as before.

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15
Q

There are 3 main processes that happen in the brain during recovery. What are they?

A

Axonal sprouting

Reformation of blood vessels, nourishing brain and strengthening connections.​

Recruitment of homologous areas on the opposite side of the brain to perform specific tasks.

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16
Q

What is axonal sprouting?

A

Neuronal regeneration.

The growth of new nerve endings will connect with other undamaged nerve cells to form new neural pathways .

17
Q

What is ‘reformation of homologous areas on the opposite side of the brain to perform specific tasks’ mean?

A

E.g. if Broca’s area was damaged, the right-sided equivalent would carry out its functions.

After a period of time, functionality may then shift back to the left side.

18
Q

State 3 factors affecting functional recovery.

A

Prior health: Physical exhaustion, stress, alcohol consumptions.

Location of injury: If the injury is in the frontal lobe, it may be less severe as there is lots of skull protection. (Weakest in temporal lobe).

Age: Deterioration of the brain in old age and therefore affects the extent and speed of recovery.

Rehab type: Whether that be intense or passive.

Motivation: Constraint induced therapy (deafferented limbs).

19
Q

Why does functional plasticity tends to decline with age?

A

As the brain has greater propensity for reorganisation in childhood as it is constantly adapting to new learning and experiences.

20
Q

Outline Bezzola et al’s study from 2012.

(Supports the idea that the brain can change in adulthood)

A

Supports the idea that the brain can change in adulthood.

This is because they found 40 hours of golf training produced changes in the neural representation of movement in PPs aged 40-60.

Using fMRI, the researchers observed reduced motor cortex activity in novice golfers compared to a control group.

This suggests there were more efficient neural representations after training.

21
Q

Evaluate practical applications of functional recovery.

A

The field of neurorehabilitation has grown due to understanding of plasticity and functional recovery.

Following trauma to the brain, spontaneous recovery tends to slow after a number of weeks so forms of neurological rehabilitation may be required to maintain improvements in functioning.

This demonstrates that although the brain (to some extent) can fix itself, this process does require further intervention if it is to be completed successfully.

22
Q

Evaluate economic implications of functional recovery.

A

People at work more due to positive rehab, chances are higher that they return to previous work place, pay taxes, contribute to the economy.

Someone would also have to take their place if they do not come back for an extended period of time.

Equipment used for longer periods of times becomes more costly, also applicable to time.

More jobs for people in neurorehabilitation areas, they are trained to be professional and qualified.

Healthcare may need to be purchased if healthcare is not free.

23
Q

Outline Hirstein et al’s study from 1988.

(Challenges the idea that all functional recovery is beneficial)

A

Challenges the idea that all functional recovery is beneficial.

This is because they found that ‘phantom limb syndrome’ affects 60-80% of people, and that the experienced sensations are usually painful - thought to be to do with cortical reorganisation in the somatosensory cortex that occurs as a result of limb loss.

This suggests that although many recover from injury, pain may still have long-term implications.

24
Q

Outline Schneider et al’s study from 2014.

(Supports the idea of education positively influencing functional recovery)

A

Supports the idea of education positively influencing functional recovery.

This is because they discovered that the more time brain injury patients spent in education – which was taken as an indication of their ‘cognitive reserve’ – the greater their chances of a disability-free recovery.

40% of PPs studied who achieved disability-free recovery had more than 16 years education compared to about 10% of patients who had less than 12 years education. ​

This suggests that a greater cognitive reserve benefits successful recovery.

25
Q

What is CTE?

A

Chronic Traumatic Encephalopathy.

A brain condition thought to be linked to repeated head injuries and blows to the head.

26
Q

Does the brain always recover from CTE? ​

A

There is no cure or treatment for CTE.

Certain medicines may be used to temporarily treat the cognitive (memory and thinking) and behavioural symptoms.

27
Q

Who does CTE effect most? Why?​

A

Athletes who play contact sports (e.g., boxers, football players, etc.)

Military veterans, likely due to their increased chances of enduring repeated blows to the head.

28
Q

State 3 long-term consequences of CTE.

A

Progressive decline of memory and cognition.

Depression

Suicidal behaviour

Poor impulse control

Aggressiveness

Dementia similar to Alzheimer’s disease.

29
Q

Are there treatments to CTE?

A

Tend to be far more physical symptoms, not psychological issues.

Certain medicines may be used to temporarily treat the cognitive (memory and thinking) and behavioural symptoms.

30
Q

What are other issues with CTE? E.g. diagnosis?

A

Can only be diagnosed after death through brain tissue analysis.

Doctors with a specialty in brain diseases slice brain tissue and use special chemicals to make the abnormality visible.

They then systematically search areas of the brain for abnormal patterns specific to CTE.