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CLINICAL CHEMISTRY > PLASMA PROTEINS > Flashcards

PLASMA PROTEINS Flashcards

1
Q

-also known as tranthyretin
-binds retinol and thyroxine

A

pre-albumin

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2
Q

sensitive marker of poor nutritional status
half life: 2 days

A

prealbumin

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3
Q

plasma protein that has a greater concentration in the CSF than in plasma

A

prealbumin

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4
Q

most abundant protein in the blood
main transport protein

A

albumin

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5
Q

plasma protein that is a major contributor to oncotic pressure

A

albumin

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6
Q

plasma protein:

assessment of nutritional status
half life: 17-21 days

A

albumin

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7
Q

plasma protein:

has the highest binding capacity
most anodal protein

A

albumin

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8
Q

this is used in cases with hemolytic anemia as it contraindicates Hba1c

A

fructosamine

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9
Q

fructosamine is also known as?

A

glycated albumin

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10
Q

plasma protein:

neutralizes trypsin and elastase

A

alpha-1-antitrypsin

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11
Q

deficiency in a1-antitrypsin results to? (2)

A

juvenile cirrhosis
pulmonary emphysema

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12
Q

plasma protein:

also known as orosomucoid

A

a1-acid glycoprotein

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13
Q

plasma protein:

transports progesterone

A

a1-acid glycoprotein

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14
Q

plasma protein:

a principal fetal antigen and an oncofetal antigen

A

a1-fetoprotein

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15
Q

plasma protein:

in amniotic fluid
decrease in a1-fetoprotein is a marker of -

A

trisomy 21/18

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16
Q

plasma protein:

in amniotic fluid
increase in a1-fetoprotein is a marker of -

A

neural tube defect/spina bifida

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17
Q

plasma protein:

in adults a1-fetoprotein is a marker for (2)

A

hepatocellular carcinoma
testicular cancer/gonondal cancer

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18
Q

plasma protein:

binds free hgb

A

haptoglobin

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19
Q

determine the hemolysis

decreased: haptoglobin
decreased: hemopexin

A

intravascular hemolysis

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20
Q

what kind of poikilocyte is seen in cases of intravascular hemolysis

A

schistocytes

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21
Q

determine what kind of hemolysis

normal: haptoglobin
decreased: hemopexin

A

extravascular hemolysis

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22
Q

what kind of poikilocyte is seen in extravascular hemolysis

A

spherocytes

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23
Q

plasma protein:

transports coppers

A

ceruloplasmin

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24
Q

a disease that is associated with

cerulosplamin deficiency
decreased in production

A

wilson’s disease

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25
Q

a disease that is associated with

copper deficiency
decrease in absorption

A

menke’s disease

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26
Q

determine the disease

serum ceruloplasmin: decreased
serum copper: decreased
copper deposits: present

A

wilson’s disease

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27
Q

determine the disease

serum ceruloplasmin: decreased
serum copper: decreased
copper deposits: absent

A

menke’s disease

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28
Q

a disease that causes kayser flescher rings

A

wilson’s disease

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29
Q

a disease that has an appearance of kinky hair

A

menke’s disease

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30
Q

plasma protein:

largest non-immunoglobulin protein

A

a2-macroglobulin

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31
Q

plasma protein:

increases 10x in nephrotic syndrome

A

a2-macroglobulin

32
Q

plasma protein:

also known as siderophilin
transports iron

A

transferrin

33
Q

plasma protein:

negative acute phase reactants (3)

A

prealbumin
albumin
transferrin

34
Q

plasma protein:

binds heme
decreased in both intravascular and extravascular hemolysis

A

hemopexin

35
Q

plasma protein:

essential in immune response, what is the most abundant

A

complement, C3

36
Q

plasma protein:

precursor of fibrin clot
seen in plasma not in serum
causes band

A

fibrinogen

37
Q

plasma protein:

major acute phase reactant
functions as opsonin in
associated with increase risk in CAD

A

c-reactive-protein

38
Q

plasma protein:

sensitive but non specific
increases 1000x in cases of inflammation/injury

A

c-reactive protein

39
Q

plasma protein:

produced by the plasma cells
protects from antigens

A

immunoglobulins/ antibodies

40
Q

most abundant immunoglobulin

A

igG

41
Q

most largest immunoglobulin

A

igM

42
Q

old name of immunoglobulins

A

gammaglobulins

43
Q

plasma proteins are synthesized in

A

liver

44
Q

made up of amino acids linked through peptide bonds

A

proteins

45
Q

proteins in presence of ammonia causes degradation converting to - which is excreted in urine

A

urea

46
Q

these are released at site of injury that causes liver to increase acute phase reactants

A

cytokines

47
Q

can predict the risk of premature birth

A

fibronectin

48
Q

protein determination method:

routine method requires 2 peptide bonds and alkaline medium
purple colored complex measured at 540nm

A

biuret method

49
Q

protein determination method:

classic method
reference method

A

kjeldahl method

50
Q

protein determination method:

involves digestion of protein and measurement of its nitrogen content

A

kjeldahl method

51
Q

protein determination method:

utilized UV method

A

direct optical method

52
Q

protein determination method:

direct optimal methods
210nm: -

A

peptide bonds

53
Q

protein determination method:

direct optimal method
280nm: -

A

amino acids: TRYYPTOPHAN

54
Q

protein determination method:

for albumin determination

A

dye-binding technique

55
Q

protein determination for albumin

bromcresol -: common

A

bromcresol green

56
Q

protein determination for albumin

bromcresol -: most specific, sensitive and precise

A

bromcresol purple

57
Q

serum protein electrophoresis:

a1: increased
a2: increased
b: increased

A

acute inflammation
immediate response

58
Q

serum protein electrophoresis:

y: increased

A

chronic inflammation
delayed response

59
Q

serum protein electrophoresis:

a1 flat curve

A

pulmonary emphysema
juvenile cirrhosis

60
Q

serum protein electrophoresis:

b-y bridging

A

hepatic cirrhosis

61
Q

serum protein electrophoresis:

increased production of fast migrating immunoglobulin

A

hepatic cirrhosis

62
Q

serum protein electrophoresis:

a2 strike

A

nephrotic syndrome

63
Q

serum protein electrophoresis:

a2, b: increased

A

nephrotic syndrome

64
Q

serum protein electrophoresis:

monoclonal gammopathy
gamma spike

A

multiple myeloma

65
Q

serum protein electrophoresis:

gamma spike in IgM

A

waldenstrom macroglubulinemia

66
Q

in presence of gamma spike in serum electoprhoresis it should be followed by?

A

immunofixation electrophoresis

67
Q

presence of a narrow band in the beta region may be due to the presence of

A

fibrinogen

68
Q

fibrinogen may cause a narrow band in what region

A

beta

69
Q

this may cause blip pattern in late a2 or early b region due to presence of free hgb

A

hemolysis

70
Q

hemolysis may cause blip in what region of serum electrophoresis

A

late a2
early b

71
Q

small blip in a2 region may be due to

A

hemoglobin-haptoglobin complex

72
Q

hemoglobin-haptoglobin complexes may cause a blip at what region

A

a2

73
Q

used to detect oligoclonal bands that are found in the gamma region

A

CSF electrophoresis

74
Q

Urine electrophoresis:

albumin: strong

A

glomerular proteinuria

75
Q

urine electrophoresis:

a1,a2,b: strong

A

tubular proteinuria

76
Q

urine electrophoresis:

monoclonal light chains

A

overflow proteinuria

77
Q

presence of monoclonal light chains in urine electrophoresis could mean overflow proteinuria what proteins are present

A

bence jones proteins

CLINICAL CHEMISTRY (1 decks)

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