PLASMA PROTEINS

Question 1

Plasmapheresis is a process in which

Answer 1

Plasma can be extracted from the subject without removing the red blood cells

Blood is withdrawn
Plasma is separated and
Red blood cells are returned to the patient

Question 2

Formation of plasma proteins

Answer 2

All albumins
All fibrinogen
50-80% globulin are formed in liver

Remaining globulin formed in lymphoid tissue

Question 3

A person with sever Renal disease can loose as high as
20g plasma proteins per day

Answer 3

This is replaced by liver which can produce as high as 30g per day

Question 4

Which liver cells produce plasma proteins

Answer 4

Parenchyma cells of liver
Reticuloendothelial cells

Question 5

Transthyretin is also know as

Answer 5

Prealbumin

Question 6

Function of transthyretin

Answer 6

Transport of thyroid hormone and retinol

Question 7

Fibrinogen function

Answer 7

Blood coagulation
Precursor of fibrin

Question 8

Albumin function

Answer 8

Maintenance of osmotic pressure in plasma which prevents plasma loss from capillaries

Question 9

Immunoglobulins function

Answer 9

Humoral immunity

Question 10

Transferrin

Answer 10

Iron transport

Question 11

Ceruloplasmin

Answer 11

Copper transport

Question 12

Haptoglobin function

Answer 12

Hemoglobin transport outside the RBC

Question 13

The thousands of plasma proteins that are present in our blood are collectively called

Answer 13

PLASMA PROTEOME

Question 14

The normal A/G ratio is

Answer 14

2:1
4.9gram Albumin per dL
2.3gram Globulin per dL

Question 15

What happens during decrease of plasma proteins concentration as a result of starvation

Answer 15

Proteins in the plasma cause colloidal osmotic pressure or ONCOTIC PRESSURE
During prolonged starvation fluid goes from intravascular space to interstitial space

Thereby causing generalised edema

Question 16

Osmotic pressure is determined not by the mass of molecules but by the

Answer 16

Number of molecules present

Question 17

Maximum to minimum number of plasma proteins molecules order

Answer 17

Albumin > Globulin > Fibrinogen

Question 18

Heaviest to lighted plasma proteins

Answer 18

Fibrinogen > Globulin > Albumin

Question 19

80% of total colloidal osmotic pressure by

Answer 19

Albumin

Question 20

Remaining 20% ONCOTIC pressure by

Answer 20

Globulin

Almost 0% by fibrinogen

Question 21

Albumin also acts as a carrier for

Answer 21

1. Steroid hormones
2. Fatty acids
3. Thyroid hormones

Question 22

SHBG
CBG
TBG

Answer 22

Sex hormone binding globulin
Corticosteroid binding globulin
Thyroxine binding globulin

Question 23

Overall functions of plasma proteins

Answer 23

1. Source of amino acids for the tissues ( reserve proteins )
2. Plasma proteins as carrier proteins(transport mechanism) Eg. TBG SBG SHBG
3. Maintenance of ONCOTIC pressure or colloidal osmotic pressure
4. Role in blood coagulation
5. Role in defence mechanism of body
6. Regulation of acid base balance
7. Maintain Viscosity of blood
8. Role in ESR (globulin and Fibrinogen accelerate roleaux formation by RBCs

Question 24

Roleaux formation by RBCs is accelerated by

Answer 24

Globulin
Fibrinogen

Question 25

In embryonic stage plasma proteins are synthesized from

Answer 25

Mesenchyme cells

Question 26

Plasma protein that is synthesized first in embryos is

Answer 26

ALBUMIN

Question 27

Gamma Globulin is synthesized from

Answer 27

B lymphocytes