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Plasma Proteins > Plasma Enzymes > Flashcards

Plasma Enzymes Flashcards

0
Q

Inherited abnormal variants of plasma cholinesterase with low biological activity

A

Decreased plasma cholinesterase

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1
Q

Hepatic disease

A

Decreased plasma cholinesterase synthesis

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2
Q

Ingestion of organophosphates or absorption via skin

A

Decreased cholinesterase activity (acts as irreversible inhibitor)

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3
Q

High levels of acetylcholine

A

Decreased plasma cholinesterase

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4
Q

Atropine sulfate

A

Decreased plasma cholinesterase (competitive antagonist)

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5
Q

Nephrotic syndrome

A

Increased plasma cholinesterase (excreted in urine)

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6
Q

Rapidly growing cells: liver recovery

A

Increased plasma cholinesterase

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7
Q

AST is normally high in what cells?

A

Cardiac and skeletal muscle, liver, kidney, erythrocytes

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8
Q

Artefactual (hemolysis) causes?

A

High AST

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9
Q

Myocardial infarction causes?

A

Very High AST

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10
Q

Circulatory failure causes?

A

Very High AST and Marked increases of ALT

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11
Q

Acute viral hepatitis causes?

A

Very High AST and Marked increases of ALT

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12
Q

Cells that have high concentrations of ALT?

A

Liver, skeletal muscle, kidney (lesser extent)

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13
Q

Liver cirrhosis causes?

A

Moderate increases of ALT

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14
Q

Cholestatic jaundice causes?

A

Moderate increases of ALT

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15
Q

Post cardiac surgery causes?

A

Moderate increases of ALT

16
Q

Skeletal muscle disease causes?

A

Moderate increases of ALT

17
Q

Pregnancy

A

Changes in ALP

18
Q

Infancy and childhood causes?

A

Changes in ALP

19
Q

High fat meals cause?

A

Changes in ALP

20
Q

Diseases that affect the bile duct cause?

A

Changes in ALP

21
Q

Bone diseases cause?

A

Changes in ALP

22
Q

What cells acid acid phosphatase found in?

A

Prostate, liver, erythrocytes, platelets, bone

23
Q

Which type of lactate dehydrogenase is indicative of myocardial infarction?

A

High LDH-1

24
Q

Which type of lactate dehydrogenase is indicative of acute hepatitis?

A

High LDH-5

25
Q

What cells is GGT normally found in?

A

Liver and bile duct, kidney, pancreas

26
Q

Induced enzyme synthesis by detox of drugs and alcohol by the gamma-glutamyl cycle in liver causes?

A

Raised GGT

27
Q

Anticonvulsants, phenobarbitone and alcohol increase or decrease GGT? Why?

A

Raised GGT.

They induce proliferation of endoplasic reticulum releasing GGT

28
Q

Cholestatic liver disease causes?

A

Raised GGT

29
Q

Hepatocellular damage causes?

A

Raised GGT

30
Q

Explain what enzymes are involved in bile duct diseases and at what levels?

A

Elevated GGT and ALP

31
Q

Explain what enzymes are involved in bone diseases and at what level?

A

Normal GGT and raised ALP

32
Q

What enzyme/s are elevated in acute pancreatitis?

A

Amylase and lipase

Plasma Proteins (8 decks)

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