plants and medicine test 2 Flashcards
what mediated immunity does delayed hypersensitivity reaction have?
cell mediated Immunity (T cells) themselves cause a reaction
Symptoms and signs of delayed hypersensitivity reaction
after 24-48 hours, macular or papular rash, burning, blisters,
plants and phytochemicals of delayed hypersensitivity reaction
Cashew, mango, and poison ivy.
(urushiol)
up to 8 diff catechols (benzene ring compound)
citrus (essential oil (terpene molecules)
Mechanism of action of delayed hypersensitivity reaction
attachment of chemical to protein in skin becomes an antigen: also macrophages, helpter T cells and cytotoxic t cells are involved.
percentage of people in america who can develop poison ivy
70-90 percent
Rx: of delayed hyper sensitivity reaction
for mild cases, take oral antihistamine.
Burrow solutions soaks for skin to dry up weeping lesions
For more severe cases, take oral cortisone (10 times a day)
what mediated immunity does immediate hypersensitivity reaction have
antibody- b cells (lymphocytes) make antibodies
Signs and symptoms of immediate hypersensitivity reaction
severity of inflammatory response
2 types
local reaction: wheel, flare
Generalized reaction: anaphylaxis= facial/ body swelling, wheezing, hives, low bp Ex. bee stings and food allergies.
plant and phytochemicals immediate hypersensitivity reaction
ragweed pollen most common in USA, many other trees. grass pollen cause allergies.
mechanism of action for immediate hypersensitivity reaction
macrophages present antigen to B cells, this produces IgE antibodies. the antibodies attach to mast cells after first exposure. mast cells release histamine upon second exposure. then inflammatory response reaction.
- protein on wall of pollen released when binds to stigma, also when binds to your respiratory mucosa
- when patient comes in contact with allergen, mast cells release histamine (steps) blood vessels “leak” thus, runny nose, watery eyes, wheel and erythematous flare.
Reaction for immediate hypersensitivity reaction
antihistamines, epinephrine SC or IV, cortisone
what can mimic immediate type 1 (wheel and erthematous flare)hypersensitivity>
irritant dermatitis. no IgE or B cells involved
signs and symptoms for immediate hypersensitivity reaction
pain, itching, wheal, erythematous flare
plant and phytochemical for immediate hypersensitivity reaction
Urticaceae family (or hives)- nettles (urtica species)
stinging hairs,
Leaves can be boiled and eaten in Europe for enlarged prostate in germany
Mechanism of action immediate hypersensitivity reaction
histamine, formic acid found in bladders within the leaf.