plants Flashcards
Chinese Evergreen
Aglaonema spp.
Toxic principle: insoluable calcium oxalate (acid)
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Alocacia, elephant’s ear
Toxicity: insoluable calcium oxalate (acid)
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Flamingo plant
toxicity: insoluable calcium oxalate (acid)
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Jack in the pulpit (Arisaema triphyllum)
toxic principles: insoluable calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Cuckoo-pint
(Arum maculatum)
toxic principles: insoluable calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Caladium varieties
toxic principles: insoluable calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, throat, mouth, vomiting
Dumcane varieties- Dieffenbachia spp
toxic principles: insoluble calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S: irritation of lips, mouth, throat, vomiting
Pothos, Devil’s Ivy (Epipremnum spp.)
toxic principles: insoluble calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Cutleaf philodendron, Swiss Cheese plant (Monstera deliciosa)
toxic principles: insoluable calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Philodendron varieties
toxic principles: insoluable calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S: irritation of lips, mouth, throat, vomiting
Peace lily (Spathiphyllum spp.)
toxic principles: insoluable calcium oxalate
MOA: penetratin via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Skunk cabbage (Sympolocarpus foetidus)
Toxic principles: insoluable calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Arrowhead vine, Nephthytis (syngonium podophyllum)
toxic principle: insoluable calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Calla lily , arum lily (Zantedeschia oethiopica)
toxic principle: insoluable calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Aralia family- Umbrella tree (Schlefflera spp)
toxic principles: insoluble calcium oxalate
MOA: penetration via needle shaped calcium oxalate crystals
C.S.: irritation of lips, mouth, throat, vomiting
Palm family -Fishtail palm (Caryota mitis)
Toxic principle: insoluable calcium oxalate
MOA: penetration by needle shaped calcium oxalated crystals
C.S.: irritation of lips, mouth, throat, vomiting
Halogeton
Toxic principles: soluble oxalate
MOA: hypocalcemia, precepitation of Ca oxalates in soft tissues and kidney damage
C.S.: hypocalcemia, kidney damage
Greasewood (Sarcobatus vermiculatus)
Toxic principles: soluble oxalate
MOA: hypocalcemia, precipitation of calcium oxalates in soft tissues and kidney damage
C.S.: hypocalcemia, kidney
Pigweed (Amaranthus retroflexus)
Toxic principles: soluble oxalate
MOA: hypocalcemia, precipitation of Ca oxalates in soft tissues and kidney damage
C.S.: hypocalcemia, methemoglobinemia, kidney damage
Beet (Beta vulgaris)
toxic principle: soluble oxalate
MOA: hypocalcemia, precipitation of Ca oxalates in soft tissues and kidney damage
C.S.: hypocalcemia, kidney damage
Lamb’s quarters (Chenopodium album)
Toxic principle: soluble oxalate
MOA: hypocalcemia, precipitation of Ca oxalates in soft tissues and kidney damage
C.S.: hypocalcemia, kidney damage
Rhubarb (Rheum rhaponiticum)
Toxic principle: soluble oxalate
MOA: hypocalcemia, precipitation of calcium oxalates in soft tissue, kidney damage
C.S. hypocalcemia, kidney damage
Sorrel and soursop (Oxalais spp)
Toxic principle: soluble oxalate
MOA: hypocalcemia, precipitation of calcium oxalates in soft tissues and kidney damage
C.S: hypocalcemia, tetany, recumbency, large doses may cause renal failure
Purslane (Portulacca oleracea)
Toxic principle: soluble oxalate
MOA: hypocalcemia, precipitation of Ca oxalates in soft tissues and kidney damage
C.S. hypocalcemia, kidney damage
Ponderosa pine (Pinus ponderosa)
Toxic principles: isocupressic acid
MOA: vasoconstriction decreases uterine blood flow, stimulates release of fetal cortisol and abortion
C.S.: abortion in cattle
Monterey cypress (Cupressus macrocarpus)
Toxic principles: Isocupressic acid
MOA: vasoconstriction decreased urine blood flow that stimulates release of fetal cortisol and abortion
C.S.: abortion in cattle
St. John’s wort- Hypericum perforatum
Toxic principle: quinone
MOA: primary photosensitization
C.S.: erythema, pruruitis, edema, necrosis of skin (secondary bacterial infections)
Buckwheat (Fagopyrun esculentum)
toxic principle: quinone
MOA: primary photosensitization
C.S.: erythema and pruritis, edema and necrosis of the skin, secondary bacterial infections
Oak Tree (Quercus spp.)
Toxic principles: Tannic acid (tannin)
MOA: tissue damage including GI lesions and kidney damage
C.S.:
Cattle: constipation, brown urine, anorexia, depression
Monogastric: mainly GI (colic, depression, hemorrhagic diarrhea, hemoglobinuria, hematuria, icterus)
Pride of Barbados
Toxic principles: Tannic acid (tannin)
MOA: tissue damage including GI lesions and kidney damage
C.S.:
Cattle: constipation, brown urine, anorexia, depression
Monogastric: mainly GI (colic, depression, hemorrhagic diarrhea, hemoglobinuria, hematuria, icterus)
Lantana (lantana camara), yellow sage
toxic principle: triterpene acids- worse in cattle
MOA: liver damage (damage of bile canaliculi, membranes, cholestasis), hepatic photosensitization, hepatic encephalopathy
C.S.: depression, anorexia, constipation, diarrhea, icterus, photophobia, erythema of skin, swelling, necrosis, sloughing
Autumn crocus, meadow saffron
Toxic principle: colchicine
MOA: antimitotic (rapidly dividing cells more susceptible)
C.S.: involves many organs: GI, respiratory, renal, hepatic
Glory Lily, climbing Lily
Toxic principle: colchicine
MOA: antimitotic (rapidly dividing cells more susceptible)
C.S.: involves many organs: GI, respiratory, renal, hepatic
Buttercup family- Larkspur, Delphinium (Delphinium spp)
Toxic principles: Diterpene alkaloids
MOA:competitive blockade of the nicotinic receptors at the muscle endplate similar to crurare
C.S. : sudden death in cattle, muscle weakness, stiffness, staggering, bloating, recumbency, collapse
TX: physostigmine
Monkshade, Aconite, Monkshood (Aconitum spp.)
Toxic principles: Diterpene alkaloids
MOA:competitive blockade of the nicotinic receptors at the muscle endplate similar to crurare
C.S. : sudden death in cattle, muscle weakness, stiffness, staggering, bloating, recumbency, collapse
TX: physostigmine
Ergot (Claviceps purpurea)
Toxic principles: Ergot Alkaloid
MOA/C.S.: vasoconstriction and gangrene, uterine contraction and abortion (chronic)
Locoweed (Astragalus spp.), Milkvetches (Oxytropis spp.)
Legume family
toxic principles: indolizidine alkaloids (swainsonine)
MOA: inhibition of lysosomal enzymes (decrease glycoprotiens), peripheral neuronal degeneration (via nitropropanolol glycoside), abnormal hoof and hair (via selenium), alteration of cellular function in brain and other organs
C.S.: neuronal signs: depression, incoordination, ataxia, circling, abnormal behavior
infertility, congenital defects, heart failure, weight loss, decreased immune system
locoism in horses
Narcissus (Narcissus spp.)
Amaryllis family
Toxic principle: lycorine
MOA: emetic and purgative, bulb most toxic
C.S.: Anorexia, saliva, vomiting, diarrhea, hypotension, muscle tremors/seizures
Kaffir lily (Clivia spp.)
Toxic principle: lycorine
MOA: emetic and purgative, bulb most toxic
C.S.: Anorexia, saliva, vomiting, diarrhea, hypotension, muscle tremors/seizures
Spider lily (Hymenocallis caribaea)
Toxic principle: lycorine
MOA: emetic and purgative, bulb most toxic
C.S.: Anorexia, saliva, vomiting, diarrhea, hypotension, muscle tremors/seizures
Barbados lily, fire lily (Hippeastrum spp)
Toxic principle: lycorine
MOA: emetic and purgative, bulb most toxic
C.S.: Anorexia, saliva, vomiting, diarrhea, hypotension, muscle tremors/seizures
Zephyr lily, rain lily (Zephyranthes spp)
Toxic principle: lycorine
MOA: emetic and purgative, bulb most toxic
C.S.: Anorexia, saliva, vomiting, diarrhea, hypotension, muscle tremors/seizures
River lily (Crinium bulbispermum)
Toxic principle: lycorine
MOA: emetic and purgative, bulb most toxic
C.S.: Anorexia, saliva, vomiting, diarrhea, hypotension, muscle tremors/seizures
Poisonous mushroom (Aminita muscaria)
Toxic principle: muscarine
MOA: stimulation of muscarinic cholinergic receptors, CNS stimulation
C.S.: delayed onset liver damage, neuro signs
Tx: Atropine, symptomatic treatment, decontaminate
Poison hemlock, spotted hemlock, California or Nebraska fern (Canium masculatum)
toxic principles: piperdine alkaloids
MOA: nicotinic effects starting with ganglionic and neuromuscular stimulation followed by ganglionic and nueromuscular blockade
C.S: mainly ataxia, incoordination, birth defects (skeletal malformation and cleft palate)
Lupines (Lupinus spp)
toxic principles: piperdine alkaloids
MOA: nicotinic effects starting with ganglionic and neuromuscular stimulation followed by ganglionic and nueromuscular blockade
C.S: mainly ataxia, incoordination, birth defects (skeletal malformation and cleft palate)
Tobacco (Nicotiana tobaccum)
toxic principles: piperdine alkaloids
MOA: nicotinic effects starting with ganglionic and neuromuscular stimulation followed by ganglionic and nueromuscular blockade
C.S: mainly ataxia, incoordination, birth defects (skeletal malformation and cleft palate)
Tree tobacco (Nicotiana gluca)
toxic principles: piperdine alkaloids
MOA: nicotinic effects starting with ganglionic and neuromuscular stimulation followed by ganglionic and nueromuscular blockade
C.S: mainly ataxia, incoordination, birth defects (skeletal malformation and cleft palate)
Coyote tobacco (Nicotiana attenuata)
toxic principles: piperdine alkaloids
MOA: nicotinic effects starting with ganglionic and neuromuscular stimulation followed by ganglionic and nueromuscular blockade
C.S: mainly ataxia, incoordination, birth defects (skeletal malformation and cleft palate)
Nightshade family- tobacco plant (nicotiana tabacum)
Toxic principles: pyridine alkaloids (nicotine and lobeline)
MOA: act on nicotinic recceptors at autonomic ganglia, NMJ, and some synapses in the CNS, low doses causes depolarization, large doses cause blockade
C.S.: rapid onset, early signs are excitation, salivation, lacrimation, vomiting, diarrhea, tachypnea, dyspnea, and muscle twitching
death due to respiratory failure
tree tobacco (Nicotiana gluca)
Toxic principles: pyridine alkaloids (nicotine and lobeline)
MOA: act on nicotinic recceptors at autonomic ganglia, NMJ, and some synapses in the CNS, low doses causes depolarization, large doses cause blockade
C.S.: rapid onset, early signs are excitation, salivation, lacrimation, vomiting, diarrhea, tachypnea, dyspnea, and muscle twitching
death due to respiratory failure
Lobelia
Toxic principles:pyridine alkaloids (nicotene and lobeline)
MOA: act on nicotinic recceptors at autonomic ganglia, NMJ, and some synapses in the CNS, low doses causes depolarization, large doses cause blockade
C.S.: rapid onset, early signs are excitation, salivation, lacrimation, vomiting, diarrhea, tachypnea, dyspnea, and muscle twitching
death due to respiratory failure
Rattlebox or crotolaria (crotolaria spp.)
Toxic principle: Pyrrolizidine alkaloids
MOA: hepatotoxic
Senecio, groundsel, ragwort
(Senecio spp)
Toxic principle: Pyrrolizidine alkaloids
MOA: hepatotoxic
Black nightshade (Solanum niger)
Toxic principles: Solanine and solanidine alkaloids
MOA/C.S.: GI, CNS, respiratory, cardiac
all plants in this family are only toxic when green and immature
MOA: similar to atropine
American nightshade (Solanum americanum)
Toxic principle: solanine and solanidine alkaloids
C.S.: GI, CNS, repiratory,cardiac
Eggplant (Solanum melongena)
Toxic principle: solanine and solanidine alkaloids
C.S.: GI, CNS, repiratory,cardiac
Tomato (Lycopersicon lycopersicon)
Toxic principle: solanine and solanidine alkaloids
C.S.: GI, CNS, repiratory,cardiac
Turkey berry (Solanum torvum)
Toxic principle: solanine and solanidine alkaloids
C.S.: GI, CNS, repiratory,cardiac
Chalice vine (Solandra guttota)
Toxic principle: solanine and solanidine alkaloids
C.S.: GI, CNS, respiratory,cardiac
Chinese lantern (Physalis spp)
Toxic principle: solanine and solanidine alkaloids
C.S.: GI, CNS, respiratory,cardiac
Japenese yew (Taxus spp.)
toxic principles: taxine alkaloids
C.S.: cardiotoxic (similar to cardiac glycosides) and GI
Jimsonweed, thornapple, angel’s trumpet (Datura stramonium)
toxic principles: tropane alkaloids (atropine, hyoscine, hyoscamine)
MOA: all parts of plant are toxic
CS: GI, CNS (convulsive seizures), mydriasis, tachycardia
Antidote: physostigmine
Angel’s trumpet (Brugmansia candida)
toxic principles: tropane alkaloids (atropine, hyoscine, hyoscamine)
MOA: all parts of plant are toxic
CS: GI, CNS (convulsive seizures), mydriasis, tachycardia
Antidote: physostigmine
Henbane (Hyoscymaus spp.)
toxic principles: tropane alkaloids (atropine, hyoscine, hyoscamine)
MOA: all parts of plant are toxic
CS: GI, CNS (convulsive seizures), mydriasis, tachycardia
Antidote: physostigmine
Cocoa (Theobroma cocao)
toxic princles: Xanthine alkaloids (caffine, theophylline, theobromide)
MOA: Blocking adenosine (A) receptors, inhibiting phosphodiesterase
C.S.: salivation, vomiting, colic, diarrhea, CNS stimulation, convulsive seizures, muscle tremors, tachycardia, hypotension, urination
Coffee (Coffee arabica)
toxic principles: Xanthine alkaloids (caffine, theophylline, theobromide)
MOA: Blocking adenosine (A) receptors, inhibiting phosphodiesterase
C.S.: salivation, vomiting, colic, diarrhea, CNS stimulation, convulsive seizures, muscle tremors, tachycardia, hypotension, urination
Cascara sagrada- from Rhamnus purshiana DC
toxic principles: anthraquinone
MOA/CS: purgative
Buckthorn (Rhamnus spp.)
toxic principles: anthraquinone
CS/MOA: purgative
Coffee weed, senna (senna occidentalis)
toxic principles: anthraquinone
MOA/C.S.: purgative, skeletal and cardiac muscle degeneration, urine may be coffee colored due to myoglobinuria, kidney damage (similar to monensin)
horses usually die from liver failure and not muscle degeneration
Aloe (Aloe vera)
toxic principle: anthraquinone
CS/MOA: purgative
Day blooming Jessamine (Cestrum diurnum)
toxic principles: calcinogenic glycoside (Vitamin D analog)
MOA/C.S.: hypercalcemia, lameness
calcification of elastic tissues of arteries, tendons, and ligaments, increased density of bones
Turkey berry (Solanum torvum)
toxic principles: calcinogenic glycoside (Vitamin D analog)
MOA/C.S.: hypercalcemia, lameness
calcification of elastic tissues of arteries, tendons, and ligaments, increased density of bones
Cocklebur (Xanthium strumarium)
Toxic principles: carboxy- atractyloside (sulfated glycoside)
CS/MOA: hepatotoxicity, excessive salivation, renal damage, hypoglycemia
Foxglove (Digitalis purpurea)
toxic principle: cardiac glycoside
MOA: cardiotoxic by inhibiting Na/K ATPase
Tx: digi-bind (digoxin immune Fab)
Oleander (Nerium oleander)
one of the most toxic plants, 1 leaf can kill animal
toxic principle: cardiac glycoside
MOA: cardiotoxic by inhibiting Na/K ATPase
Tx: digi-bind (digoxin immune Fab)
Yellow oleander, lucky nut, Be-still tree (Thevetia peruviana)
toxic principle: cardiac glycoside
MOA: cardiotoxic by inhibiting Na/K ATPase
Tx: digi-bind (digoxin immune Fab)
Squill (ureginea maritima)
toxic principle: cardiac glycoside
MOA: cardiotoxic by inhibiting Na/K ATPase
Tx: digi-bind (digoxin immune Fab)
Lily of the valley (Convallaria majalis)
toxic principle: cardiac glycoside
MOA: cardiotoxic by inhibiting Na/K ATPase
Tx: digi-bind (digoxin immune Fab)
Milkweed (asclepias spp)
toxic principle: cardiac glycoside
MOA: cardiotoxic by inhibiting Na/K ATPase
Tx: digi-bind (digoxin immune Fab)
Kallanchoe
toxic principle: cardiac glycoside
MOA: cardiotoxic by inhibiting Na/K ATPase
Tx: digi-bind (digoxin immune Fab)
Periwinkle (Cathanranthus roseus)
toxic principle: cardiac glycoside
MOA: cardiotoxic by inhibiting Na/K ATPase
Tx: digi-bind (digoxin immune Fab)
Sweet clover (Melilotus officinalis)
Toxic principles: Coumarin glycoside
MOA: form dicoumarol in spoiled plants. Inhibit Vitamin K epoxide reductase resulting in deficiency of coag factors: II, VII, IX, X (1972)
C.S. hemorrhage
Antidote: Vitamin K1 or whole blood
Wild Cherries (Prunus spp.)
toxic principles: cyanogenic glycosides
MOA: release HCN on hydrolysis in damaged plants, metabolized in liver to thiocyanates
C.S.:
acute: inhibition of cytochrome oxidase and inhibition of cellular respiration, vasoconstriction, inhibition of glycolysis, inhibition of citric acid cycle, irritation of MM
Chronic: neuronal degeneration
Johnsongrass, Sudan Grass, Sorghum (Sorghum spp.)
toxic principles: cyanogenic glycosides
MOA: release HCN on hydrolysis in damaged plants, metabolized in liver to thiocyanates
C.S.:
acute: inhibition of cytochrome oxidase and inhibition of cellular respiration, vasoconstriction, inhibition of glycolysis, inhibition of citric acid cycle, irritation of MM
Chronic: neuronal degeneration and antithyroid effect
Elderberry (Sambucus canadensis)
toxic principles: cyanogenic glycosides
MOA: release HCN on hydrolysis in damaged plants, metabolized in liver to thiocyanates
C.S.:
acute: inhibition of cytochrome oxidase and inhibition of cellular respiration, vasoconstriction, inhibition of glycolysis, inhibition of citric acid cycle, irritation of MM
Chronic: neuronal degeneration and anti-thyroid effect
Sago palm (Cycas circinalis)
toxic principle: Cyasin
MOA: glycoside that causes GI irritation and liver damage, teratogenic, mutagenic, carcinogenic- ß-methylamino-L-alanine (BMAA) –> neurotoxic AA, unknown toxin–> axonal degeneration in CNS
C.S.: GI and liver damage (dogs), GI and weight loss (sheep), Zamia staggers- ataxia, weaknes weight loss (cattle)
also can cause CNS signs
Japanese cycad (Cycas revoluta)
toxic principle: Cyasin
MOA: glycoside that causes GI irritation and liver damage, teratogenic, mutagenic, carcinogenic- ß-methylamino-L-alanine (BMAA) –> neurotoxic AA, unknown toxin–> axonal degeneration in CNS
C.S.: GI and liver damage (dogs), GI and weight loss (sheep), Zamia staggers- ataxia, weaknes weight loss (cattle)
also can cause CNS signs
Cardboard palm (Zamia furfuraceae)
toxic principle: Cyasin
MOA: glycoside that causes GI irritation and liver damage, teratogenic, mutagenic, carcinogenic- ß-methylamino-L-alanine (BMAA) –> neurotoxic AA, unknown toxin–> axonal degeneration in CNS
C.S.: GI and liver damage (dogs), GI and weight loss (sheep), Zamia staggers- ataxia, weaknes weight loss (cattle)
also can cause CNS signs
Coontie (Zamia pulmila)
toxic principle: Cyasin
MOA: glycoside that causes GI irritation and liver damage, teratogenic, mutagenic, carcinogenic- ß-methylamino-L-alanine (BMAA) –> neurotoxic AA, unknown toxin–> axonal degeneration in CNS
C.S.: GI and liver damage (dogs), GI and weight loss (sheep), Zamia staggers- ataxia, weaknes weight loss (cattle)
also can cause CNS signs
Rape seed, kale, broccoli, brussel sprouts, cabbage, turnip, cauliflower
Brassica spp.
toxic principle: glucosinolate (thiocynate glycoside)
C.S./MOA: antithyroid
Soybean (Glycine spp.)
toxic principle: glucosinolate (thiocynate glycoside)
C.S./MOA: antithyroid
Flax (Linum spp.)
toxic principle: glucosinolate (thiocynate glycoside)
C.S./MOA: antithyroid
Milkvetch (Astragalus spp.)
toxic principles: nitropropanol glycoside
MOA: inhibits enzymes of the Krebs cycle and cellular oxidative phosphorylation
C.S.
cattle and sheep: respiratory and neurologic signs (cracker heels or roaring disease)
horses and rodents: neurologic signs
Violets (Viola spp.)
toxic principles: nitropropanol glycoside
MOA: inhibits enzymes of the Krebs cycle and cellular oxidative phosphorylation
C.S.
cattle and sheep: respiratory and neurologic signs (cracker heels or roaring disease)
horses and rodents: neurologic signs
Lotus
toxic principles: nitropropanol glycoside
MOA: inhibits enzymes of the Krebs cycle and cellular oxidative phosphorylation
C.S.
cattle and sheep: respiratory and neurologic signs (cracker heels or roaring disease)
horses and rodents: neurologic signs
Indigo (Indigofera spp.)
toxic principles: nitropropanol glycoside
MOA: inhibits enzymes of the Krebs cycle and cellular oxidative phosphorylation
C.S.
cattle and sheep: respiratory and neurologic signs (cracker heels or roaring disease)
horses and rodents: neurologic signs
White clover (Trifolium repens)
Toxic principles: phytoestrogens
MOA: bind to estrogen recpetors causing infertility in females and males
C.S.: infertility in female, decreased libido and feminization in males
Subterranean clover (Trifolium subterraneum)
Toxic principles: phytoestrogens
MOA: bind to estrogen recpetors causing infertility in females and males
C.S.: infertility in female, decreased libido and feminization in males
Alfalfa (Medicago sativa)
Toxic principles: phytoestrogens
MOA: bind to estrogen recpetors causing infertility in females and males
C.S.: infertility in female, decreased libido and feminization in males
Buttercup family (Ranunculaceae): Anemone, Ranunculus, Clematic, Hellborus
MOA: protoanemonin (volatile oil)
MOA: volatile oil released by hydrolysis of glycoside
C.S.: severe irritation of GI mucosa and dermatitis
Braken fern (Pteridium aquilinum)
toxic principle: Ptaquiloside
MOA: death of precursor cells in the BM, neoplasm in the UT, tumors in the URT, retinal degeneration (bright blindness*)
C.S.: acute onset aplastic anemia, anorexia, hemorrhage, enzootic hematuria- blood in urine, anemia, tachycardia, death
Agave (Agave lechugilla)
toxic principles: steroidal saponins
MOA: liver damage and inability to eliminate phylloerythrin, a metabolite of cholorophyll which acts as a photodynamic substance , hepatogenic photosensitization
C.S.:signs of photosensitization and liver damage
Beargrass (Nolina spp)
toxic principles: steroidal saponins
MOA: liver damage and inability to eliminate phylloerythrin, a metabolite of cholorophyll which acts as a photodynamic substance , hepatogenic photosensitization
C.S.:signs of photosensitization and liver damage
Grass family (Pancium spp.)
toxic principles: steroidal saponins
MOA: liver damage and inability to eliminate phylloerythrin, a metabolite of cholorophyll which acts as a photodynamic substance , hepatogenic photosensitization
C.S.:signs of photosensitization and liver damage
Pancium vigratum
toxic principles: steroidal saponins
MOA: liver damage and inability to eliminate phylloerythrin, a metabolite of cholorophyll which acts as a photodynamic substance , hepatogenic photosensitization
C.S.:signs of photosensitization and liver damage
Dracaena spp.- Madgascar Dragon Tree, Song of India, Cornstalk, Dwarf bouquet or Calypso queen,
toxic principles: steroidal saponins
MOA: mainly GI irritation
C.S.: GI signs including hypersalivation, nausea, vomiting which may be bloody, colic and diarrhea, depression in dogs and cats, dilated pupils in cats
Cordyline spp.
toxic principles: steroidal saponins
MOA: mainly GI irritation
C.S.: GI signs including hypersalivation, nausea, vomiting which may be bloody, colic and diarrhea, depression in dogs and cats, dilated pupils in cats
Molybdenum
toxic principles: molybdenum
C.S./MOA: signs of copper deficiency including watery bubbly diarrhea, wasting, depigmentation, demyelination, osteoporosis
Clovers
Toxic principles: Copper
MOA/C.S.: liver damage, hemolysis, methemoglobinemia
Aster
Toxic principles: selenium
C.S./MOA:
Acute: GI irritation and respiratory signs
Chronic: hoof and hair abnormalities
Woody aster (Xylorrhiza spp.)
Toxic principles: selenium
C.S./MOA:
Acute: GI irritation and respiratory signs
Chronic: hoof and hair abnormalities
Princess’s plume (Stanlyea spp.)
Toxic principles: selenium
C.S./MOA:
Acute: GI irritation and respiratory signs
Chronic: hoof and hair abnormalities
Milk vetch (Astragalus spp.)
Toxic principles: selenium
C.S./MOA:
Acute: GI irritation and respiratory signs
Chronic: hoof and hair abnormalities
Goldenwood (Onopsis spp.)
Toxic principles: selenium
C.S./MOA:
Acute: GI irritation and respiratory signs
Chronic: hoof and hair abnormalities
Paintbrush (Castilleja spp.)
Toxic principles: selenium
C.S./MOA:
Acute: GI irritation and respiratory signs
Chronic: hoof and hair abnormalities
Saltbrush (Atriplex spp.)
Toxic principles: selenium
C.S./MOA:
Acute: GI irritation and respiratory signs
Chronic: hoof and hair abnormalities
Alfalfa (Medicago Sativa)
Toxic principles: selenium
C.S./MOA:
Acute: GI irritation and respiratory signs
Chronic: hoof and hair abnormalities
Tall grasses (Sorghum spp)
Toxic principles: selenium
C.S./MOA:
Acute: GI irritation and respiratory signs
Chronic: hoof and hair abnormalities
Pigweed (Amaranthus retroflexus)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Oats (Avena sativa)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Johnsngrass, Sudangrass, Milo (Sorghum spp.)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Corn, Maize (Zea mays)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Beet (Beta vulgaris)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Lamb’s quarters (Chenopodium album)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Sweet clover (Melilotus officinalis)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Alfalfa (Medicago sativa)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Wheat (Triticum aestivum)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Sunflower (Helianthus annuus)
Toxic principles: Nitrate
MOA/C.S.:
Acute: GI irritation. Nitrate is reduced to nitrate by nitrate reductase. Nitrate causes oxidation of ferrous iron of hemoglobin to ferric iron, forms methemoglobin. Respiratory insufficiency signs due to inability of the blood to carry oxygen. Fetal methemolobinemia and death causing abortion.
Chronic: decreased progesterone during pregnancy and abortion. Reduced performance
Mustards (Brassica spp.)
Toxic principles: Dimethyl dislfide
MOA: plant contains 5-methyl cysteine sulfoxide- reduced to dimethyl disulfide, causes oxidation of RBCs and heinz body anemia
C.S.: anemia, depression, hemoglobinuria, hemoglobinemia, icterus, cyanosis
Spurge family- Chenille plant, Cat tail (Acalypha hispida)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Croton (Cadiaeum variegatum)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Candalabra “cactus” (Euphorbia lacta)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Crown of thorns (Euphorbia milli var splendens)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Poinsettia (Euphorbia pulcherrima)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Pencil tree (Euphorbia tirucalli)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Manchineel (Hippomane manchinella)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Sandbox tree (Hura crepitans)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Physicnut (Jatropha curas)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Wild physicnut (jatropha gossipifolia)
Toxic principles: diterpene esters
MOA: activate protein kinase C resulting in cell damage and enzyme dysfunction
C.S.: irritation and blistering of GI mucosa–> salivation, vomiting and diarrhea (with/without blood)
usually mild in small animals, may be severe in large animals (especially horses)
Rhodendron, Azalea (Rhodedendron spp.)
Toxic principles: Grayanotoxins
MOA: binds to Na channels in excitable cells (nerve, skeletal muscle, cardiac muscle, CNS), increase permeability and depolarization, irritation of GI mucosa
C.S.: GI signs, depression, recumbency, tachycardia, tachypnea, seizures, fever. Death due to aspiration pneumonia.
Mountain laurel, sheep laurel, sheepkill (Kalmia spp.)
Toxic principles: Grayanotoxins
MOA: binds to Na channels in excitable cells (nerve, skeletal muscle, cardiac muscle, CNS), increase permeability and depolarization, irritation of GI mucosa
C.S.: GI signs, depression, recumbency, tachycardia, tachypnea, seizures, fever. Death due to aspiration pneumonia.
Japanese pieris, mountain pieris (Pieris spp.)
Toxic principles: Grayanotoxins
MOA: binds to Na channels in excitable cells (nerve, skeletal muscle, cardiac muscle, CNS), increase permeability and depolarization, irritation of GI mucosa
C.S.: GI signs, depression, recumbency, tachycardia, tachypnea, seizures, fever. Death due to aspiration pneumonia.
Dog hobble, dog laurel, black laurel (Leucothoe spp.)
Toxic principles: Grayanotoxins
MOA: binds to Na channels in excitable cells (nerve, skeletal muscle, cardiac muscle, CNS), increase permeability and depolarization, irritation of GI mucosa
C.S.: GI signs, depression, recumbency, tachycardia, tachypnea, seizures, fever. Death due to aspiration pneumonia.
Mapleberry, fetter bush, stagger bush (Lyonia spp.)
Toxic principles: Grayanotoxins
MOA: binds to Na channels in excitable cells (nerve, skeletal muscle, cardiac muscle, CNS), increase permeability and depolarization, irritation of GI mucosa
C.S.: GI signs, depression, recumbency, tachycardia, tachypnea, seizures, fever. Death due to aspiration pneumonia.
Castor bean (Ricinus communis)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
Precatory bean (Abrus precatorius)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
Coral plant (Jatropha crucas)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
Sandbox tree (Hura crepitans)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
Black locus (Rhobina pseudocacia)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
Beans (soybeans, kidney, pinto, navy)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
Mahogony family- Chinaberry (Melia azedarrach)
toxic principle: meliatoxin
MOA: enterotoxic, neurotoxic
C.S.: GI signs with or withoug blood, CNS and peripheral neuronal signs similar to nicotine poisoning, death from respiratory failure
Amarlyllis family (Onion, garlic, shallots, chives, leek)- Allium spp.
toxic principle: propyl disulfide
MOA: oxygen free radicals–> damage RBC membranes–> heinz bodies
C.S.: anorexia, ataxia, tachycardia, tachypnea, dyspnea, icterus, onion odor, abortion
Horsebrush (Tetradymia spp.)
Toxic principle: Tetradymol
MOA: liver damage and inability to eliminate phylloerythrin, a metabolite of chlorophyll which acts as a photodynamic substance, hepatogenic photosensitization
C.S.: **sheep**anorexia, depression, incoordination, dyspnea, icterus, head pressing,skin swelling, erythema, necrosis, sloughing, secondary bacterial infections
Horsetail (Equisetum hyemale)
toxic principle: thiaminase
MOA/C.S.: destroys thiamine in the diet and produces signs of thiamin (Vita B1) deficiency in monogastric animals (neurotoxic)
Braken fern (Pteridium aquilinum)
toxic principle: thiaminase
MOA/C.S.: destroys thiamine in the diet and produces signs of thiamine (Vita B1) deficiency in monogastric animals (neurotoxic)
Alfalfa (Medicago sativa)
toxic principle: triterpenoid saponins
MOA: direct irritation of the GI mucosa
C.S.: salivation, vomiting, anorexia, diarrhea, colic, hypothermia
Hollyy family- English holly, Christmas holly (Ilex aquifolum)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
American holly (Ilex opaca)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
Ginseng family-English Ivy, common ivy (Hendra helix)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
Pokeweed family- pokeweed, inkberry (Phytolacca americana)
toxic principle: lectin (phytotoxin, toxalbumin)
MOA: inhibit cellular protein synthesis resulting in cell death
C.S.: GI signs including hemorrhagic gastroenteritis
Milkweed family (Asclepias spp.)
Toxic principles: resin or resinoids
MOA/C.S.: irritation of nervous or muscle tissue
Opium family- Marijuana (cannibis sativa)
Toxic principles: resin or resinoids
MOA/C.S.: irritation of nervous or muscle tissue
Mahogony family- Chinaberry (Melia azedarach)
Toxic principles: resin or resinoids
MOA/C.S.: irritation of nervous or muscle tissue
Legume family- Alsike clover (Trifolium hybridium)
toxic principles: alsike clover and red clover
MOA: hepatotoxicity and secondary photosensitization in horses only (due to liver damage), hepatic encephalopathy at large doses, primary photosensitization also
C.S.:lacrimation, photophobia, erythma, pruritis, edema, necrosis, sloughing of skin
Red clover (Trifolium pratense)
toxic principles: alsike clover and red clover
MOA: hepatotoxicity and secondary photosensitization in horses only (due to liver damage), hepatic encephalopathy at large doses, primary photosensitization also
C.S.:lacrimation, photophobia, erythma, pruritis, edema, necrosis, sloughing of skin
Laurel family- Avocado (Persea americana)
toxic principles: avocado
CS/MOA: cardiotoxicity in goats, horses, rabbits, and caged birds
noninfectious mastitis and agalactica in cattle, horses, goats, and rabbits
Black walnut
toxic principles: black walnut
C.S./MOA: ingestion of fresh shavings made from heartwood (as bedding), causes laminitis
Legume family- moldy alfalfa (medicago sativa)
toxic principles: forage-induced photosensitization
MOA: primary photosensitization, secondary photosensitization due to liver damage
C.S.:lacrimation, photophobia, erythma, pruritis, edema, necrosis, sloughing of skin
Grass family- moldy wheat (triticum aestivum)
toxic principles: forage induced photosensitization
MOA: primary photosensitization, secondary photosensitization due to liver damage
C.S.:lacrimation, photophobia, erythma, pruritis, edema, necrosis, sloughing of skin
Grape family- Grapevine (Vitis spp)
Toxic principles: grapes and raisins
MOA: unknown toxin causes renal failure only in dogs
C.S.: GI signs including vomiting followed by signs of acute renal failure
Lily family- Easter Lily (Lilium longiflorum)
toxic principle: Lily
MOA: an unknown toxin causes renal failure only in cats (two leaves can cause poisoning), GI irritation in dogs and cats
C.S.: GI signs including salivation, vomiting, depression, complete anorexia, PU followed by anuria and death from renal failure
Tiger Lily (Lilium tigrinum)
toxic principle: Lily
MOA: an unknown toxin causes renal failure only in cats (two leaves can cause poisoning), GI irritation in dogs and cats
C.S.: GI signs including salivation, vomiting, depression, complete anorexia, PU followed by anuria and death from renal failure
Japanese show lily (Lilium hybridium)
toxic principle: Lily
MOA: an unknown toxin causes renal failure only in cats (two leaves can cause poisoning), GI irritation in dogs and cats
C.S.: GI signs including salivation, vomiting, depression, complete anorexia, PU followed by anuria and death from renal failure
Day lily (Hemerocallis spp.)
toxic principle: Lily
MOA: an unknown toxin causes renal failure only in cats (two leaves can cause poisoning), GI irritation in dogs and cats
C.S.: GI signs including salivation, vomiting, depression, complete anorexia, PU followed by anuria and death from renal failure
Pigweed family- redroot pigweed (Amaranthus spp.)
toxic principle: pigweed
MOA:
acute: nitrate–>methemoglobinemia
chronic: abortion
soluable oxalate: hypocalcemia and kidney damage
unknown: renal tubular damage–> ruminants, horses, pigs
C.S.: depression, weakness, incoordination, renal failure
Red maple family (acer rubrum)
toxic principle: red maple
MOA: unknown toxin in dried leaves–> hemolytic anemia, hemoglobinemia, heinz bodies
C.S.: anorexia, depression, anemia, icterus, brown MM, hemoglobinuria, dyspnea, cyanosis, death
may cause renal failure
Legume family- Coffee senna (senna occidentalis)
toxic principles: senna
MOA: unknown mechanism–> skeletal muscle myopathy and cardiomyopathy, anthroquinone–> cathartic
C.S.: diarrhea, muscle weakness, recumbency, good appetite, myoglobinuria, coffee colored urine, tachycardia, death
Sicklepod (Senna obtusifolia)
toxic principles: senna
MOA: unknown mechanism–> skeletal muscle myopathy and cardiomyopathy, anthroquinone–> cathartic
C.S.: diarrhea, muscle weakness, recumbency, good appetite, myoglobinuria, coffee colored urine, tachycardia, death
Sunflower family- yellow starthistle (centaurea solstitialis)
toxic principles: yellow starthistle and Russian knapweed
MOA: toxins interact with dopamine transporters resulting in death of dopaminergic neurons in the brain
C.S.: equine nigropallidal encephalomalacia (ENE) or chewing disease- sudden onset of inability to eat or drink, drowsiness interuppted by excitation, head down, dehydration
Russian knapweed (Acropitilon repens, Centaurea repens)
toxic principles: yellow starthistle and Russian knapweed
MOA: toxins interact with dopamine transporters resulting in death of dopaminergic neurons in the brain
C.S.: equine nigropallidal encephalomalacia (ENE) or chewing disease- sudden onset of inability to eat or drink, drowsiness interrupted by excitation, head down, dehydration
Protea family
Macademia
toxic principle: macademia nuts
MOA: unknown, toxin is unknown
C.S. dog- onset of signs within 12 hours- weakness in hindlimbs, depression, ataxia, tremors, hyperthermia, lameness, recumbency, vomiting, colic, diarrhea, pale MM. Full recovery in 2 days
Cactus family
toxic principle: mechanical injury
MOA/C.S.: thorns, spines, stinging, or irritating hair
Jimsonweed seed pods (Datura stramonium)
toxic principle: mechanical injury
MOA/C.S.: thorns, spines, stinging, or irritating hair
Cocklebur seed pods (xanthium strumarium)
mechanical injury
thorns, spines, stinging or irritating hair
