Placebo

Question 1

Can analgesia be produced by placebo?

Answer 1

Yes

Question 2

PET results show increase in opioid activity in several areas of brain:

Answer 2

DLPFC, ACC, Insula, Nucleus accumbens

Question 3

fMRI study placebo induced analgesia

Answer 3

a. applied inert cream to lessen pain of heat or electrical shock
b. increased activation of DLPFC and periaqueductal gray

Question 4

Placebo analgesia can be blocked by…

Answer 4

naloxone

Question 5

S’s trained to increase and decrease ACC activity with fMRI feedback

Answer 5

• S’s could tolerate more pain when ACC activation decreased and less when ACC activation was increased
• False feedback about ACC activity and training to alter posterior cingulate had no effect on pain tolerance

Question 6

Genital stim

Answer 6

decreases pain