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Cirrhosis > PKPD Changes in Cirrhosis > Flashcards

PKPD Changes in Cirrhosis Flashcards

1
Q

cirrhosis effect on first pass

which drugs?

A

dec first pass bc dec CYP enzyme production

ex) propranolol, morphine, carvedilol, diazepam

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2
Q

what is the alternate for diazepam in cirrhosis and why

A

lorazepam because it has phase 2 metabolism instead of phase 1

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3
Q

ppb

A

dec ppb
inc effect of high ppb drugs
ex) phenytoin

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4
Q

renal fxn

A

decreased, inc SCr

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5
Q

therapeutic response of benzos

A

inc BBB permeability of benzos and opioids in cirrhosis may need to monitor and decrease dose to compensate

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Cirrhosis (5 decks)

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