PK/PD and Adjustments Flashcards
Beta Lactams
PK/PD:
Adjustment:
Pk/PD: Type 2
Adjust: Renally
Which Beta-Lactams have different Adjustments?
Penicillinase-Resistant Penicillins
3rd Gen Cephalosporing (Usually Renal)
Glycopeptides
PK/PD:
Adjustment:
Type 3
Renal
Tetracyclines
PK/PD:
Adjustment:
Type 3
Liver
Fluoroquinolones
PK/PD:
Adjustment:
Type 1
Renal
Macrolides
PK/PD:
Adjustment:
Type 2 or 3
Liver
Clindamycin
PK/PD:
Adjustment:
Type 3
Liver
Metronidazole
PK/PD:
Adjustment:
Type 3
Liver
Bactrim
PK/PD:
Adjustment:
Type 3
Renal
Aminoglycosides
PK/PD:
Adjustment:
Type 1
Renal
Nitrofurantoin
PK/PD:
Adjustment:
Type 3
Renal
Oxazolidinones
PK/PD:
Adjustment:
Type 2
Liver
Daptomycin
PK/PD:
Adjustment:
Type 1
Renal
Streptogramins
PK/PD:
Adjustment:
Type 3
Liver
Rifampin
PK/PD:
Adjustment:
Type 3
Liver
Fosomycin
PK/PD:
Adjustment:
Type 1
None
Fidaxomicin
PK/PD:
Adjustment:
Type 3
None
Type 1 PK/PD
24 hour AUC/MIC and Peak (Cmax/MIC)
Max. Concentration
Type 2 PK/PD
T>MIC
Max. Duration
Type 3 PK/PD
24 hour AUC/MIC
Max. Amoun
Which TB drugs
have LIVER monitoring?
Rifampin Rifapentine Rifabutin Isoniazid Pyrazinamide
Which TB drugs have RENAL adjustments?
Ethambutol Pyrazinamide Fluoroquinolones (L) Aminoglycosides Capreomycin
Which Malaria drugs have RENAL adjustments?
A-P
Which Malaria drugs have LIVER adjustments?
Chloroquine A-L Mefloquine Doxycycline Clindamycin
