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Clinical PK > PK of Direct Acting Antivirals (DAA) of HCV > Flashcards

PK of Direct Acting Antivirals (DAA) of HCV Flashcards

1
Q

What is the generic name of Harvoni?

A

Sofosbuvir/ledipasvir

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2
Q

What is the generic name of Epclusa?

A

Sofosbuvir/velpatasvir

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3
Q

What is the generic name of Vosevi?

A

Sofosbuvir/velpatasvir/voxilapravir

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4
Q

What is the generic name of Mavyret?

A

Glecaprevir/pibrentasvir

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5
Q

What is the generic name of Zepatier?

A

Elbasvir/grazoprevir

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6
Q

Name the generic drug(s) that are NS5A inhibitors [Hint: think of names that have an ‘a’ towards the end]

A

Ledipasvir
Velpatasvir
Pibrentasvir
Elbasvir

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7
Q

Name the generic drug(s) that are NS5B nucleotide polymerase inhibitors [Hint: think of names that have a ‘b’ towards the end]

A

Sofosbuvir

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8
Q

Name the generic drug(s) that are NS3/4A protease inhibitors [Hint: think of previr at the end of the name]

A

Voxillaprevir
Glecaprevir
Grazoprevir

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9
Q

Which medication is the only anti-viral for HCV taken 3 times a day?

A

Glecapravir/pibrentasvir (Mavyret)

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10
Q

How long does it take for all DAAs to be absorbed (generally)?

A

About 3 hours

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11
Q

(T/F) - ALL DAA for HCV have to be taken without food

A

FALSE - DAA for HCV can be taken with or without food

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12
Q

Which drug(s) is/are renally eliminated? & how much?

A

Sofosbuvir - 80%

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13
Q

Which drug(s) is/are biliary/feces eliminated?

A 
Ledipasvir
Velpatasvir
Pivrentasvir
Glecaprevir
Voxillaprevir
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14
Q

Which drug(s) is/are predominately removed by feces and minimal by the kidneys?

A

Elbasvir and grazopravir

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15
Q

In which combined medications are rifampin contraindicated with?

A

Vosevi, Mavyret, and Zepatier

Remember all protease inhibitors

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16
Q

Which DRUGS are contraindicated with rifampin?

A

NS3/4A Protease Inhibitors

  • Voxilaprevir
  • Glecaprevir
  • Grazoprevir
17
Q

In which medications is St. John’s Wort (P-gp inducer) not recommended or contraindicated? Why?

A

ALL OF THEM; will reduce the meds concentration

18
Q

Which anticonvulsants are not recommended in Harvoni, Epclusa, and Vosevi?

A

Carbamazepine
Phenytoin
Phenobarbital
Oxcarbazepine

19
Q

Which antiarrhythmic drug is not recommended in Harvoni, Epclusa, and Vosevi? Why not?

A

Amiodarone; bradycardia can occur

20
Q

Carbamazepine and phenytoin (only these two) are CONTRAINDICATED in which medication?

A

Zepatier (elbasvir and grazoprevir)

21
Q

What is the only medication NOT RECOMMENDED with nafcillin (CYP3A inducer)? Why?

A

Zepatier (elbasvir and grazoprevir); concentration of zepatier will decrease

22
Q

Which medication is not recommended with rosuvastatin?

A

Harvoni (sofosbuvir and ledipasvir)

23
Q

Which 3 medications is antacids not recommended to be used simultaneously? How can it be avoided?

A

Harvoni (sofosbuvir and ledipasvir)
Epclusa (sofosbuvir and velpatasvir)
Vosevi (sofosbuvir, velpatasvir, and voxilaprevir)
Separate antacids by 4 hours

24
Q

Can H2 blockers (famotidine) be taken with Harvoni, Epclusa, and Vosevi?

A

Yes, but just the max of 40 mg BID

25
Q

Can PPI blockers (omeprazole) be taken with Harvoni, Epclusa, and Vosevi?

A

Yes, but just the max of 20 mg QD

26
Q

Can antacids, H2 blockers, and PPI inhibitors be taken with Zepatier and Mavyret?

A

YES; no interactions

27
Q

Which 4 medications increase the concentration of digoxin?

A

Harvoni (sofosbuvir and ledipasvir)
Epclusa (sofosbuvir and velpatasvir)
Vosevi (sofosbuvir, velpatasvir, and voxilaprevir)
Mavyret (glecaprevir and pibrentasvir)

28
Q

Which medication does not affect digoxin levels?

A

Zepatier (elbasvir and grazoprevir)

29
Q

Can Harvoni be taken simultaneously with rosuvastatin?

A

NO

30
Q

Can Harvoni be taken with other statins?

A

YES

31
Q

Can Epclusa, Vosevi, Mavyret, and Zepatier be taken with rosuvastatin?

A

YES

32
Q

What is the max dose that rosuvastatin can be taken as?

A

10 mg QD

33
Q

Can pravastain be taken with all of the HCV medications?

A

YES

34
Q

What is the max does pravastatin can be taken as?

A

40 mg QD

35
Q

Which 2 medications is cyclosporine not recommended with?

A

Vosevi (sofosbuvir, veltapasvir, voxilaprevir)

Mavyret (pibrentasvir and glecaprevir)

36
Q

Which medication is cyclosporine contraindicated with?

A

Zepatier (elbasvir and grazoprevir)

37
Q

Which medication should tacrolimus be monitored closely with?

A

Zepatier (elbasvir and grazoprevir)

Clinical PK (11 decks)

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