PK Data Analysis Flashcards
1
Q
How to calculate K elim
A
K elim = -gradient of the ln(conc of drug) vs time graph
2
Q
How to calculate Co
A
Co = ln(y intercept) = e^(y intercept) of the ln(conc of drug) vs time graph
3
Q
How to calculate t1/2
A
T1/2 = 0.693/ k elim
4
Q
How to calculate vd
A
Vd= dose/Co of the ln(conc of drug) vs time graph (make sure u use the units used in the graph)
5
Q
How to calculate AUC
A
AUC = Co/ k elim
6
Q
How to calculate bioavailability, F
A
F= AUC (oral) / AUC (iv)
7
Q
How to calculate total clearance CL
A
CL = vd x k elim
8
Q
What is he units for Vd
A
Litres or if they give you the weight u can do L/Kg
9
Q
For CL do u use L/Kg or L measurements
A
Litressss not L/kg
