Pituitary Like Hormones Of Placenta Flashcards
A protein hormone so-named because it has lactogenic properties in bioassays and
prolactin-like activity in radioreceptor assay.
Placental lactogen
A protein has an amino acid
composition similar to ovine prolactin and ovine growth hormone.
Ovine placental lactogen (oPL)
The binucleate trophoblastic cells migrate across the feto-maternal junction and
fuse to form a ?
syncytium
highest concentrations between of oPL
120 and 140 days of gestation,
It is used commonly in veterinary medicine to duplicate the
biological effects of LH and FSH.
Chorionic (i.e., placental) gonadotropins
Human chorionic gonadotropin (hCG) for medical use is obtained from
urine of pregnant women
The α subunit hCG is a single chain
92 amino acid
β subunit consists of
145 amino acids.
The placenta of the mare also produces a gonadotropin called
equine chorionic gonadotropin (eCG) or
pregnant mare serum gonadotropin (PMSG)
They are
formed when trophoblastic cells from the chorion attach to the endometrial epithelium and
migrate into the endometrium.
The endometrial cups
Is high FSH-like activity and is administered to cows to induce superovulation for embryo transfer
Equine CG
Beside lactogens and gonadotropins, the placenta also produces peptides with
GnRH-, TRH-, GHRH-,
CRH-, and ACTH-like activities.
Placental lactogens appear
to plays roles
regulating mammary gland function, fetal growth,
maternal intermediary metabolism, and
ovarian steroidogenesis.