Pituitary Gland Flashcards
Hypothalamus Hormones
Anterior pituitary
TRH thyrotropin releasing hormone. (To produce thyroid hormone)
Gonadotropin Releasing hormone GnRH
Corticotropin Releasing hormone CRH
Growth hormone releasing hormone GHRH (Induce LH & FSH)
Growth hormone inhibiting hormone GHIH
Prolactin inhibiting hormone PIH (dopamine)
Posterior pituitary
ADH antidiuretic hormone (vasopressin)
Oxytocin
Thyroid hormones
T4 thyroxin
T3 Triiodothyronine
T4 is converted to t3 via D1/D2 or to rT3 via D1
Hypothyroidism
Levothyroxine T4
Liothyronine T3
Liotrix T4/T3
Natural Thyroid T4/T3
Hyperthyroidism
Propylthiouracil
Methimazole
Inhibit thyroid peroxidase inhibiting iodide oxidation.
Inhibit coupling of iodothyrocines in thyroglobulin.
Propylthiouracil also Also inhibits D1/D2 which converts t4 to t3
GnHR agonist
Goserelin
Histerlin
Leuprolide
Nafarelin
GnRH antagonist
Degarelix
Elagolix
Ganirelix
Cetrorelix
LH FSH alternative
Menotropin (LH/FSH) Urofollitropin FSH Folitropin FSH Lutropin LH Choriogonadotropin alfa (human gonadotropin)
Addison’s disease
Low corticosteroids
Fludrocortison
Hydrocortisone
Prednisone
Cushing Syndrome
Hyper corticosteroids
Ketoconazole
Mitotane
Metyrapone
Growth hormone
Somatotropin
Dwarfism & gigantism
Dwarfism:
Mecasermin
Somatotropin
Gigantism:
Octreotide
Lanreotide
Bind to Somatostatin receptors and mimic
Pituitary hormones resulting from hypothalamus Hormones
Thyrotrophs ( via TRH) Gonadotropes (via GnRH) Corticotropes (via CRH) Somatotropin (via GHRH) Inhibits somatotropin (via GHRH) Inhibits secretion of prolactin (via PIH or Dopamine)
Prolactin
Prolactin secretion
D2 receptors blockers metoclopramide
Prolactin inhibiting
D2 rec agonist
Bromocriptin
Cabergoline
Vasopressin
Desmopressin
Vasopressin
Antagonist
Conivaptan
Tolvaptan
Thyroid diagnosis
Hypothyroidism Primary High TSH Low T4 Secondary Low TSH Low T4
Hyperthyroidism
Low TSH
High T4
