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YAY! Dems Unit 3 > Pituitary Dsfxn > Flashcards

Pituitary Dsfxn Flashcards

1
Q

Acromegaly hormone cause

A

GH excess

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2
Q

hypogonadism hormone excess

A

PRL

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3
Q

hypogonadism hormone deficiency

A

FSH/ LH

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4
Q

SIADH hormonal cause

A

ADH excess

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5
Q

DI hormonal cause

A

ADH deficiency

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6
Q

target organ hormone
ACTH
GH
LH/FSH

A

ACTH: cortosol and DHEA-s
GH: Liver- IGF
LH/FSH: men~ testosterone, women estradiol

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7
Q

Hypothalamic Activators/ Inhibitors

  1. somatotrophe
  2. lactotrope
  3. Corticotrope
  4. Gonadotrope
  5. Thyrotrope
A
  1. somatotrophe: GHRH +; SFIF -
  2. lactotrope: TRH+; DA-
  3. Corticotrope: CRF+
  4. Gonadotrope: GnRh+
  5. Thyrotrope: TRH+; SRIF-
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8
Q

Anterior Pituitary hormone, Site of Action, Product

  1. somatotrophe
  2. lactotrope
  3. Corticotrope
  4. Gonadotrope
  5. Thyrotrope
A
  1. somatotrophe: GH–> Liver –> IGF-1
  2. lactotrope: Prolactin–> breast –> lactation
  3. Corticotrope: ACTH–> adrenal–> cortisol & DHEA
  4. Gonadotrope: FSH,LH –> Gonads –> sex steroids
  5. Thyrotrope: TSH –> thyroid –> T4, T3
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9
Q

pituitary macro adenomas are present in what percent of acromegaly?

A

80%

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10
Q

most important serum test AoGHD/ GH excess

A

IGF-1

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11
Q

most important serum test Prolactinoma

A

PRL level

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12
Q

5 specific signs of cushings

A
  1. moon facies
  2. wide >1cm violaceous striae
  3. spontaneous ecchymoses
  4. proximal muscle weakness
  5. early/ atypical osteoporosis
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13
Q

Central adrenal sufficiency corisol cutoff level

A

random am cortisol level 18 excludes diagnosis

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14
Q

CLinical presentation
Prolactinoma
cushings disease
gonadotrope adenomas

A

Prolactinoma: Female> male; 10:1; age 34 *most common

cushing’s disease: female> male middle age

gonadotrope adenomas: Male>female; middle age; macro adenomas

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15
Q

blood test gonadotrope adenoma

A

low FSH/LH, T, E2

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16
Q

loss of pituitary hormone order

A

GH/ FSH/ LH
TSH/ ACTH
PRL

17
Q

ADH deficiency tumor basis

A

metastatic tumors or craniopharyngiomas but not pituitary adenomas

18
Q

ADH release

A

high osmolar state via hypothalamic osmoreceptors

hypovolemia via baroreceptors

19
Q

ADH mech on 2 receptors

A

V1: vasoconstriction; platelet aggregation
V2: antidiuretic effects kidney: water reabsorption
-Adenylate cyclase activation –> aquaporin water channels to cell membrane

YAY! Dems Unit 3 (3 decks)

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