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CLP - Endocrinology > Pituitary Disease > Flashcards

Pituitary Disease Flashcards

1
Q

sign of low ACTH

A

panhypopituitary

loss of pigmentation

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2
Q

sign of low FSH/LH

A

oligomenorrhoea

hypogonadism

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3
Q

sign of low prolactin

A

failure of lactation

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4
Q

sign of low ADH

A

diabetes insipidus
polyuria
polydispsia

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5
Q

prolactinoma sizes and gender

A

younger women <10mm

men and elderly women >10mm

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6
Q

signs and symptoms of prolactinoma

A 
galactorrhoea
amenorrhoea
hypogonadism
erectile dysfunction
arrested puberty
stimulates milk production
inhibits HnRH and gonadotropin production
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7
Q

size of GH secreting tumour

A

mm-cm

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8
Q

signs and symptoms of GH secreting tumour

A

change in appearance
increase height
acromegaly/gigantism

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9
Q

size of ACTH secreting tumour

A

majority <10mm

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10
Q

signs and symptoms of ACTH secreting tumour

A

Cushing’s syndrome

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11
Q

size of TSH secreting tumour

A

> 10mm

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12
Q

S+S of TSH secreting tumour

A

hyperthyroidism

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13
Q

size of non-functioning tumour

A

most >10mm @ presentation

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14
Q

signs and symptoms of non functioning tumour

A

hypopituitarism

mechanical S+S

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15
Q

list the causes of a non-functioning large pituitary adenoma

A 
compression
bitemporal hemianopia (optic chiasm)
ocular palsies (CN II,IV,VI) and diplopia
hypopituitarism
signs of increase ICP (headache)
hypothalamic: hunger, thirst, sleep
ventricles and sphenoid sinuses
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16
Q

list the causes of a functioning large pituitary adenoma

A

acromegaly
hyperprolactinaemia
cushings
mass effects

17
Q

what is acromegaly?

A

excress GH that stimulates skeletal and soft tissue growth

18
Q

causes of acromegaly?

A

pituitary tumour in most cases

paraneoplastic release of GH from non-pit tumours

19
Q

S+S of acromegaly

A 
increase hand/foot size
sweating
large tongue
HTN
prominent supraorbital ridge
protruding mandible
interdental separation
poor libido
symptoms of DM, hypopituitarism
visual deterioation
20
Q

diagnosis of acromegaly

A

HIGH IGF-1
GTT: glucose >2mcg/ml @ hours
(normal = suppression of glucose)

CLP - Endocrinology (7 decks)

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