Pituitary and Brain Hormones Flashcards
Brain, pituitary and pineal Anatomy
- All very close together
- Reasons
1. Pituitary- half is nervous tissue; some hormones produced in the brain and needed for release
2. Pineal- modified neurons
Main brain centers involved in endocrine regulation (inside hypothalamus)
Many different areas of neurons. Two important for this module:
- Paraventricular and supraoptic nuclei
- arcuate nucleus
Paraventricular and supraoptic nuclei
- Regulate water balance
- Produce Antidiuretic Hormone (ADH; water balance) and oxytocin (muscular contractions)
- Destruction causes diabetes insipidus
- Paraventricular nucleus projects to autonomic nuclei of brainstem and spinal cord
Arcuate nuclei
- Produces hypothalamic releasing factors (regulate secretion of the anterior pituitary)
- Contains DOPA-ergic neurons that inhibit prolactin release
Nucleus in brain
Clusters of neuronal cell bodies (perikaryon) in the CNS
Development of the Pituitary Gland
- Comes from folding inwards and together of Neuroectoderm and Oropharynx ectoderm/Rathke’s pouch (Specialized epithelial cells- secretory in nature)
- Produces two halves: Half neural called the posterior lobe (neurohypophysis) and half specialized epithelial called the anterior lobe (adenohypophysis)
Regions of pituitary gland/hypophysis
All species have all regions, but organization does differ
- Adenohypophysis (anterior lobe) separated into:
- Pars Distalis- most number of cells
- Pars Tuberalis- acts as a sleeve of the infundibulum stalk
- Pars Intermedia- plays a huge role in cushings disease of Horse (PPID) - Neurohypophysis (posterior lobe) separated into:
- Pars Nervosa- only see neuron terminals (axons) of the paraventricular nuclei and supraoptic nuclei
- Infundibulum- Nerve tract that leads from hypothalamus to pars nervosa is the stalk.
Pars Distalis cell distribution
Most number of excretory cell types out of all regions
Median Eminence
Base of hypothalamus where hormones converge into the system heading to the anterior pituitary
Anterior Pituitary Association and Hormonal secretion
Large number of neurons in hypothalamus produce hypothalamic releasing hormones (stimulating hormones) & can produce some inhibitors as well (hypothalamic releasing inhibitory factors). These hormones and factors effect the hormone production of the anterior pituitary
Steps of hormonal secretion to anterior pituitary
- Neurons end at base of hypothalamus (median eminence) and release hormonal contents there
- Blood vessels (network of capillaries= hypothalamo-hypophyseal portal system) present in this region. They pick up these hypothalamic releasing hormones and carry them to anterior pituitary region.
- Hormones act as regulatory hormones in the anterior region causing the release of pituitary hormones
Follicle stimulating hormone (FSH) and Luteinizing hormone (LH)
- Pituitary hormone
- target ovaries and testes
Thyroid stimulating hormone (TSH)
- Pituitary hormone
- target thyroid
Adrenocorticotropic hormone (ACTH)
- Pituitary hormone
- target adrenal cortex
Prolactin
- Pituitary hormone
- target mammary glands