Pituitary

Question 1

6 dogs w pituitary dependent HAC wo neurologic signs
RT: 4Gy x 11 = 44Gy, MWF, POP w Co-60

Cushing’s signs resolved in ___ %

Answer 1

Cushing’s signs resolved in 50%

Question 2

6 dogs w pituitary dependent HAC wo neurologic signs
RT: 4Gy x 11 = 44Gy, MWF, POP w Co-60

___ dogs achieved CR on reCT 1y post RT

Answer 2

4/6 dogs achieved CR on reCT 1y post RT

Question 3

6 dogs w pituitary dependent HAC wo neurologic signs
RT: 4Gy x 11 = 44Gy, MWF, POP w Co-60

RT did or did NOT control Cushing’s dz?

Answer 3

Did NOT control well

Question 4

6 dogs w pituitary dependent HAC wo neurologic signs
RT: 4Gy x 11 = 44Gy, MWF, POP w Co-60

___ % tumor size reduction were seen in 2 dogs

Answer 4

25 % tumor size reduction were seen in 2 dogs

Question 5

24 dogs w pituitary macrotumors (>1cm) w neurologic signs
19 functioning (elevated ACTH), 5 non-functioning 
RT: 4Gy x 12 = 48Gy, MWF, POP w Co-60

MPFS =

Answer 5

MPFS = 12mo

Question 6

24 dogs w pituitary macrotumors (>1cm) w neurologic signs
19 functioning (elevated ACTH), 5 non-functioning 
RT: 4Gy x 12 = 48Gy, MWF, POP w Co-60

MTT improve neurologic signs =

Answer 6

MTT improve neurologic signs = 16 days post RT

Question 7

24 dogs w pituitary macrotumors (>1cm) w neurologic signs
19 functioning (elevated ACTH), 5 non-functioning 
RT: 4Gy x 12 = 48Gy, MWF, POP w Co-60

2y Cushing’s control rate =

Answer 7

2y Cushing’s control rate = 32%

Question 8

24 dogs w pituitary macrotumors (>1cm) w neurologic signs
19 functioning (elevated ACTH), 5 non-functioning 
RT: 4Gy x 12 = 48Gy, MWF, POP w Co-60

What are 3 factors correlated w tumor size?

Answer 8

What are 3 factors correlated w tumor size?

1. Relative tumor size & severity of signs
2. Relative tumor size & remission of neuro signs postRT
3. Relative tumor size & ACTH concentration

Question 9

24 dogs w pituitary macrotumors (>1cm) w neurologic signs
19 functioning (elevated ACTH), 5 non-functioning 
RT: 4Gy x 12 = 48Gy, MWF, POP w Co-60

2 Px factors of duration of remission of signs =

Answer 9

2 Px factors of duration of remission of signs =

1. relative tumor size
2. endocrine activity

Question 10

24 dogs w pituitary macrotumors (>1cm) w neurologic signs
19 functioning (elevated ACTH), 5 non-functioning 
RT: 4Gy x 12 = 48Gy, MWF, POP w Co-60

1 Px factor affected OST =

Answer 10

1 Px factor affected OST = severity of neurologic signs

Question 11

24 dogs w pituitary macrotumors (>1cm) w neurologic signs
19 functioning (elevated ACTH), 5 non-functioning 
RT: 4Gy x 12 = 48Gy, MWF, POP w Co-60

Which of functional vs non-functional pituitary macrotumor did better? (lived longer)

Answer 11

Functional pituitary macrotumor lived longer

Question 12

24 dogs w pituitary macrotumors (>1cm) w neurologic signs
19 functioning (elevated ACTH), 5 non-functioning 
RT: 4Gy x 12 = 48Gy, MWF, POP w Co-60

Large RT field was associated w more brain damage
T or F?

Answer 12

True

Question 13

24 dogs w pituitary macrotumors (>1cm) w neurologic signs
19 functioning (elevated ACTH), 5 non-functioning 
RT: 4Gy x 12 = 48Gy, MWF, POP w Co-60

What is the Px factor associated w the duration of eucortisol?

Answer 13

What is the Px factor associated w the duration of eucortisol?

None

Question 14

___ % of PDH have macrotumors
___ % of PDH develop neurologic signs
___ % of macrotumor don’t produce hormone

Answer 14

30% of PDH have macrotumors
50% of PDH develop neurologic signs
10% of macrotumor don’t produce hormone