PIH Flashcards

Hypertension in pregnancy

1
Q

Chronic HTN in pregnancy

A

Hypertensive before 20 wks of pregnancy.
Pt htn before pregnancy.
bP doesn’t come back to normal after delivery.

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2
Q

PIH

A

HTN more than 20 wks of pregnancy.
Due to placental pathology.
BP will come back to normal within 12 wks.

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3
Q

GESTATIONAL HTN PREECLAMPSIA

  • Proteinuria
  • End organ damage
A
  • Absent present

* Absent present

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4
Q

End organ damage

A
Any one of the following shld be present
 Platelet count less than 1 lakh
 S creatinine more than 1.1
 Liver enzymes raised 2x than normal value
 Presence of cerebral or visual symptoms
 Pulmonary edema.
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5
Q

Chronic HTN with superimposed preeclampsia

A

A hypertensive female conceives and suddenly at 20 wks if she notice any one of the following
1 uncontrolled BP
2. New onset proteinuria
3. New onset end organ damage.

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6
Q

Signs of impending eclampsia in severe preeclampsia pt
Symptoms
Tx

A
  1. epigastric pain ± nausea, vomiting
    Due to formation of subcapsular hematomas causing liver capsule to stretch.
  2. headache which is not responding to usual Tx
    ± dizziness due to cerebral hypoxia
  3. New onset visual disturbance
    Convulsions. Hypertensive retinopathy
    KEITH WAGNER BAKER CLASSIFICATION

Tx: mgso4
Doc for treating and preventing convulsions in a pt with pih.

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7
Q
HELLP SYNDROME
 Pt came with epigastric pain on right upper quadrant pain in third trimester.
H     hemolysis
EL    elevated liver enzymes
LP    low platelet count
A
HEMOLYSIS   any two of four +
1. On peripheral blood smear: schistocytes/ helmet cells/ burr cells +
2. Serum bilirubin levels ≥ 1.2
3. Decreased haptoglobin 
4. LDH increase ≥ 600 IU.
EL: SGOT & SGPT ≥ 70 IU/L
LP: platelet count< 1 lakh
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8
Q

Risk factors for PIH or preeclampsia

A
  • Previous history of preeclampsia/ past history of chr HTN/ family history of HTN
  • Chr kidney disease.
  • Primigravida female
  • New paternity.
  • Diabetes placentomegaly
  • syndromes APLA, metabolic X syndrome
  • Pregnancy twin preg, molar preg, Rh neg preg.
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9
Q

How to prevent PIH

A

Aspirin 50 – 150 mg/d
Started from 12 wks of pregnancy not later than 16 wks and continued throughout pregnancy.

Given only to females who have identifiable symptoms.

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10
Q

Tests to predict preeclampsia

A

Most common uterine A Doppler
Outdated test gaints roll over test
Recent predictors :
Increases :- anti angiogenic factors
Sflt 1
S endoglin
Vasoconstrictors
Thromboxane A2
Decreases :- angiogenic factors
VEGF
Placental gf
Vasodilator
Nitric oxide.

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11
Q

Management of PIH
2 types
1. Non specific management
2. Definitive management or specific

A
    • Use of anti HTN therapy
    • Anti convulsant
    • Termination of pregnancy.
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12
Q

PIH CONDITION TOP

  1. mild preeclampsia
  2. severe preeclampsia
  3. impending eclampsia
  4. eclampsia
  5. HELLP SYNDROME
  6. Complication
    • Fetal disturbances
    • Kidney failure
    • Abruptio
A

TOP

  1. ≥ 37 wks
  2. ≥ 34 wks
  3. Immediately top
  4. Immediate top
  5. Immediate top
  6. Immediate top
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13
Q

Anti hypertensive therapy:

  • Most common mode of delivery
  • Indications for cesarean
  • Medication, management of preeclampsia
A
  • vaginal delivery
    1. Epidural analgesia
    2. Catheterization in eclampsia
    3. Cut short 2nd stage by intermediate delivery
    Prophylactic use of forceps or vaccum.
    1. After delivery: methylergometrine is C/I.
  • Poor bischop score
    AEDF
    REDF
  • Oral therapy given if BP ≥ 150/100 but ≤160/110
    IV therapy if BP ≥ 160/110. Hypertensive crisis
    ¶CAN BE GIVEN ¶ CONTRAINDICATED
  • Labetalol * ace inhibitors
  • Methyldopa * losartan
  • Nifedipine * diuretics
  • Hydralozine * all beta
  • Ntg blockers
  • Sodium Except
    Nitroprusside Labetalol.
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14
Q
  1. DOC for PIH:
  2. DOC for hypertensive crisis in preg
  3. DOC for chr. HTN in preg
  4. DOC for refractory HTN in preg
  5. DOC for acute hypertensive crisis in preg
A
  1. Labetalol
  2. IV labetalol max dose 220mg
    Initially give 20 mg.. if not decreased give 40 mg…..80mg……..80mg.
    Labetalol is C/I in asthamatic pts.
    For asthamatic IV hydralozine
  3. Labetalol > methyldopa
  4. sodium nitroprusside usually not given bcz it can lead to cyanide toxicity.
  5. 1st DOC: IV labetalol 220mg
    2nd DOC: IV hydralozine
    Sustained release nifedipine
    IV NTG drip
    Refractory cases: sodium nitroprusside
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15
Q
  1. What is eclampsia?
  2. Why seizure?
  3. Which eclampsia has worst prognosis?
A
  1. When a pt with preeclampsia throw generalized tonic clonic seizures.
  2. In eclampsia BP increases……… vasoconstriction……. decrease blood flow in brain…….central hypoxia.
  3. Antepartum eclampsia M.C worst prognosis.
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16
Q
#Management of eclampsia
# Definitive management
A

1st step: secure the airway ( mouth gag, O2 by masks, aspirate the secretions)

2nd step: Anti convulsant therapy MgSo4.
3rd step: IV anti HTN like labetalol.
# TOP immediate.

17
Q

MgSo4 role in treating convulsions

A

MgSo4 can prevent convulsions only if thy are due to vasoconstriction bcz of PIH.
Not an anti HTN Drug
*Acts on NMDA receptors in brain… Blocks them….
Cerebral vasodilation….. Decreases cerebral hypoxia…… convulsions treated.
* Blocks ca channel’s. Ca channel blockers shldnt be combined with MgSo4 it can lead to respiratory arrest.

18
Q

Pritchard regime: dose of MgSo4

A
* Loading dose: 14gms
  IV 4gms 20% solution
  IM 10gms 50% solution. 5gms in left buttock and 
 5gms in right buttock.
* Maintanence dose: 5gms
  IM 5gms 50% in alternate buttocks.
19
Q

Therapeutic range of MgSo4

A
4 – 7 meq/ L
     Or
2 – 3.5 mmol/L
     Or
4.8 – 8.4 mg/ dl
20
Q

Maintanence dose of MgSo4

A
Shld be given every 4 hourly
Before each dose check
1. Patellar reflex
2. Urine output
3. RR ≥ 12 breath/ min
4. Spo2 ≥ 96%
If any of these is abnormal donot give maintanence dose.
This dose shld be given till 24 hrs after last convulsion or 24 hrs after delivery.
21
Q

Signs and symptoms of MgSo4 toxicity

Antidote?

A
1st sign loss of patelar reflex ≥10 meq/L
Slurring of speech, diaphoresis
Resp depression ≥ 12 meq/L
Resp arrest occurs ≥ 15 meq/L
Cardiac arrest occurs ≥ 30meq/L

Antidote: ca gluconate IV 10ml of 10%