PID Flashcards

1
Q

What is PID?

A

Pelvic inflammatory disease- acute and subclinical infection of the upper genital tract in women. It comprises a spectrum of inflammatory diseases involving any combo of the uterus, fallopian tubes, ovaries. Often accompanied by involvement of neighboring pelvic organs

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2
Q

what does PID result in?

A

Results in endometritis, salpingitis, oophoritis, pelvic peritonitis, perihepatitis, and/or tubo- ovarian abcess (TOA)

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3
Q

Acute PID hard to diagnose because of the wide variation in s/s, which are?

A
unilateral or bilateral lower abdominal or pelvic pain
fever
vomiting
abnormal vaginal discharge
irregular vaginal bleeding
pain with intercourse
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4
Q

*many episodes of PID go undiagnosed and untreated because ??

A

the patient and/or practitioner fails to recognize the implications of mild or nonspecific signs and symptoms

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5
Q

Silent PID

A

term that can be applied to women with very minimal or no symptoms, represents a large portion of all PID cases

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6
Q

what is happening in subclinical PID

A

mild inflammation is occurring within the reproductive tract at a very low level, yet damage to the fallopian tubes or surrounding structures is occurring

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7
Q

important for clinicians to recognize the implication of mild/ non specific findings, especially

A

in young female patients who might give an incomplete or inaccurate sexual history

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8
Q

how can PID occur (less likely)

A

can be blood- borne, ie. TB or result from an intra- abdominal process or gyn procedures that disrupt the protective cervical barrier

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9
Q

how does PID usually occur

A

most often develops when bacteria ascend from the vagina or cervix into the endometrium, fallopian tubes, and pelvic peritoneum. majority (85%) of cases caused by sexually transmitted pathogen or bacterial vaginosis- associated pathogens

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10
Q

risk factors for PID

A
a previous h/o of PID
higher numbers of lifetime sex partners
douching
h/o bacterial STD
age younger than 25
having a partner with an STI
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11
Q

gyn procedures that disrupt the protective cervical barrier

A
pregnancy termination
IUD insertion
dilation and curettage
hysterosalpingography
- all elevate the risk of PID and may lead to PID in the absence of the classic sexually transmitted pathogen
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12
Q

time course of presentation of PID

A

typically acute over several days but can be weeks to months

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13
Q

clinical diagnosis remains..

A

the most important practical approach

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14
Q

15% of cases of PID are NOT sexually transmitted and instead are associated with..

A

enteric pathogens (E.coli, bacteroides fragilis, group B strep, and campylobacter spp) or respiratory pathogens (h. influenzae, strep pneumoniae, group A strep, and staph aureus) that have colonized in the lower GI tract

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15
Q

what other things can produce a similar clinical picture

A

post- op pelvic cellulitis and abscess, pregnancy- related pelvic infection, injury or trauma- related pelvic infection, and pelvic infection secondary to spread of another infection

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16
Q

who is at risk?

A

any sexually active female is at risk for STI associated PID

-those w/ multiple partners at higher risk

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17
Q

PID during pregnancy rare because

A

the mucus plug and decidua seal off the uterus from ascending bacteria.

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18
Q

PID rare during pregnancy but possible

A
  • can occur within first 12 weeks of gestation before the mucus plug seals off the uterus
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19
Q

our level of suspicion should always be high, especially

A

in adolescents

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20
Q

what is the goal of the initial evaluation of women with suspected PID?

A

to establish a presumptive diagnosis of PID

  • assess for additional findings that increase the liklihood of that diagnosis
  • evaluate for other potential causes of pelvic pain
21
Q

issues pertaining to high- risk sexual behavior and acquisition of STI are common to both adolescents and adults but

A

are intensified among adolescents because of both behavioral and biological predispositions

22
Q

behavioral factors that put adolescents and young women at high risk for STI’s and PID are

A

inconsistent use of barrier protection
douching
greater number of current/ lifetime sexual partners
use of ETOH and other substances that may impair judgement while engaging in sexual activity

23
Q

what to use to reduce risk of PID

A

latex condoms

24
Q

use of oral contraceptives

A

may also reduce risk of PID (associated with a decrease in the severity of inflammation)

25
what will your PID pt possible look like? exam findings vary but may include:
oral temp >101F lower abdominal tenderness w/ or w/o peritoneal signs cervical or vaginal discharge tenderness with lateral motion of the cervix uterine tenderness unilateral or bilateral adnexal tenderness and adnexal fullness pyuria- abundant WBCs on saline microscopy of vaginal fluid elevated c- reactive protein and/ or adnexla mass demonstrated by abdominal or transvaginal US
26
where does PID come from/ most common pathogens
studies from europe and US from the 80's found its caused by C trachomatis and N. gonorrhoeae or both about 50% of cases
27
M. genitalium has been associated with
endometritis and PID
28
Actinomyces israelli is a cause of
PID in women with IUDs
29
most common pathogens of PID
neisseria gonorrhoeae and chlamydia trachomatis
30
other organisms from upper genital tract that can cause PID
anaerobes such as bacteroides species and peptostreptococcus species facultative anaerobes such as gardnerella vaginalis, haemophilus influenzae, strep species, actinomyces enteric gram negative bacilli and cytomegalovirus
31
genital mycoplasms also associated with PID including
mycoplasma genitalium, mycoplasma hominis, and ureaplasma urealyticum
32
etiology of PID
polymicrobial common, but in more than half the cases, no organism is identified in the specimen
33
complications of PID
perihepatitis (fitz- hugh- curtis syndrome) and tubo- ovarian abscess/ complex formation
34
long term sequelae
tubal scarring that can cause - infertility in 20% of females - ectopic pregnancy in 9% chronic pelvic pain in 18%
35
factors that may increase the likelihood of infertility
delay in diagnosis or initiation of antimicrobial therapy younger age at time of infection chlamydial infection PID determined to be severe by laparoscopic exam
36
*perihepatitis aka fitz- hugh- curtis syndrome
occurs in setting of PID when there is inflammation of the liver capsule and peritoneal surfaces of the anterior right upper quadrant - there is generally minimal stromal hepatic involvement - was first associated with gonococcal salpingitis in 1920 and subsequently C trachomatis
37
perihepatitis aka fitz- hugh- curtis syndrome cont
occurs in approximately 10% of women with acute PID and is chracterized by RUQ abdominal pain with a distinct pleuritic component, sometimes referred to as the right shoulder - marked tenderness at RUQ on exam - the severity of pain in this location may mask PID and lead to concerns of cholecystitis - aminotransferase are usually normal or only slightly high - on laparoscopy or visual inspection, it manifests as "violin string"- patchy purulent and fibrinous exudate, most commonly affecting the anterior surfaces of the liver (not the liver parenchyma)
38
ABX of choice for coverage of c. trachomatis
1st choice doxycycline. azithromycin has shown activity against this pathogen too
39
has moderate in vitro activity against n. gonorrhoeae and c. trachomatis
the combo clindamycin and gentamicin
40
have excellent in vitro activity against n. gonorrhoeae and c. trachomatis
second generation cephalosporin (cefoxitin, cefotetan) plus doxy
41
what do you NOT give to treat gonorrhea or associated conditions
fluoroquinolones bc of increased resistance
42
if you suspect PID
you should treat- even if you are not sure
43
CDC recommends initiating treatment of PID in who?
all sexually active young women with adenexal tenderness or cervical motion tenderness (these criteria are sensitive but not specific)
44
treatment against PID directed at what?
c. trachomatis, n. gonorrhoeae, gram negative facultative anaerobes, vaginal anaerobes, and stretococci
45
2 most important sexually transmitted organisms associated with acute PID
c. trachomatis, n. gonorrhoeae- these should be the target of tx. However negative endocervical screeening for either of these pathogens does not rule out upper tract infection
46
diagnosis of PID difficult to make because
studies have been unable to identify any single clinical finding or constellation of findings that allow accurate identification of women with PID
47
most cases of PID
probably go undiagnosed
48
when PID diagnosis is made clinically
might not be supported by laparoscopic evidence/ surgical findings
49
treatment guidelines from CDC 2015
make chart on paper!