Physiology Week 1 Flashcards

1
Q

ICF is found where? ECF?

A

ICF: within the cell
ECF: bathes and surrounds the cells

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2
Q

Another word for homeostasis that describes a stable internal environment

A

Dynamic equilibrium

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3
Q

What are the cells requirements?

A

Maintain functional integrity, perform organ function, and contribute to organism’s survival

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4
Q

Define homeostasis.

A

Ability of the body to maintain a relatively stable internal environment despite external variances

Maintenance of steady states in the body by coordinated physiological mechanisms

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5
Q

Total volume of body water and its distribution

A
42L total
2/3: intracellular (40%)
1/3: extracellular (20%); 
    3/4: interstitial/lymph
    1/4: plasma

Note: water is 50% and 60% of body weight for women and men, respectively

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6
Q

What is transcellular fluid?

A

Fluids outside of normal compartments; I.e. CSF, digestives fluids, and mucus

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7
Q

Sodium extracellular electrolytes range

A

136-145 mmol/L (mEq/L)

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8
Q

Potassium extracellular electrolyte range

A

3.5 - 5 mmol/L (mEq/L)

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9
Q

Intracellular sodium range

A

6 - 14 mmol/L (mEq/L)

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10
Q

Intracellular potassium electrolyte range

A

154 mmol/L (mEq/L)

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11
Q

Osmolarity of body fluid compartments

A

290 mOsm

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12
Q

Homeostasis requires __________, while equilibrium does not

A

Energy expenditure

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13
Q

What is steady state?

A

Maintenance of a state that does not change with time that usually required energy expenditure

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14
Q

Define equilibrium

A

Two compartments that have the same amount and free energy; bonnet energy transfer between compartments

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15
Q

What is the relationship between steady state and homeostasis?

A

Steady state is the means by which homeostasis is maintained

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16
Q

Steady state or equilibrium:
A) water
B) ECF
C) ICF

A

A) equilibrium
B) steady state
C) steady state

17
Q

Feedback mechanisms are what kind of loops? Feedforward?

A

Feedback: CLOSED
Feedforward: OPEN

18
Q

Negative feedback vs positive feedback

A

Negative: opposes original change
Positive: amplifies original change until an end point in reached

19
Q
Which of the following variable is not controlled by homeostasis?
A. Blood pressure
B. Blood glucose
C. Heart rate 
D. Arterial PO2
E. Blood pH
A

C. Heart rate; HR is and effector, not a variable

20
Q

What is significant about negative feedback mechanism of blood glucose?

A

Pancreas B-cells are the sensor, comparator, and effector. There is no CNS involvement.

21
Q

What are the 4 set point deviations?

A
  1. 24 hr cycle: circadian rhythm
  2. Environmental changes: altitude
  3. Protective response: fever
  4. Aging/pathological changes: atheramatous plaques (accumulation of degenerative materials)
22
Q

What is redundancy?

A

More than one mechanism to control an important variable

23
Q

Mechanisms of hypovolemic shock

A

Aortic arch/carotid sinus:

  1. hypothalamus/posterior pituitary -> ADH: wafer reabsorption & vasoconstriction
  2. Medulla oblongata -> sympathetic output & parasympathetic decrease: vast constriction & increase in heart rate contractual it’s

Kidney/JG cells:
1. Angiotensin/angiotensin II-> adrenal cortex -> aldosterone : Na+ resorption

24
Q

Result of deficient homeostatic mechanism

A

Disease: negative feedback becomes positive feedback leading to disastrous consequences

Ex. Chronic heart failure: CO falls -> body retains fluid -> increase of load -> inc. chance of failure