Physiology of aging Flashcards
What are the causes of aging?
1) DNA damage theory of aging
2) Cytoplasmic changes (ROS)
3) Dysfunction of an organ that will affect other organs
What are the types of aging?
1) Primary aging
- Physiological
2) Secondary aging
- Pathologic (depends on habits)
Which organ is affected the most by aging?
Heart
What is meant by health span?
Years of life free of diseases
What are the different treatments for aging?
1) Enhance DNA repair
2) Twesk with genes (delete or add some genes to delay aging)
3) Increase In telomere length
4) Reset epigenetic changes
5) Antioxidants
6) Stem cells
7) Hormone therapy
8) Fecal transplants (as the intestinal microbiome releases proteins into the blood that keep us young and healthy)
What is meant by progeria?
An autosomal dominant disease of accelerated cell death
- Mutation that weakness the structure of the nucleus causing the cell to:
1) divide poorly
2) DNA accumulates oxidative damage
3) DNA become unstable