Physiology Brs Flashcards

0
Q

Solution 150mM NaCl is …tonic

A

Isotonic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Solution 300mM mannitol is …tonic

A

Isotonic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

At the muscle end plate ACh causes the opening of

A

Na and K channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

At the muscle end plate ACh causes …polarization to which value

A

Depolarization to a value halfway the Na and K equilibrium potentials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Why hyperkalemia causes muscle weakness?

A

Because Na channels are closed by depolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Function of γ-motoneurons

A

Innervate intrafusal myscle fibers –> adjust the sensitivity of the muscle spidle so that it will respond appropriately during muscle contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Decerebrate rigidity is caused by

A

Increased reflex muscle spindle activity due to removal of inhibition of higher centers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What kind of lesions cause decerebrate rigidity?

A

Lesions above the lateral vestibular nucleus and lesions above the pontine reticular formation but below the midbrain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The excessive muscle tone in decerebrate rigidity can be reversed by

A

Cutting the dorsal roots

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Second order neurons in the olfactory pathway

A

Mitral cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Low doses of epinephrine cause vasodilation/vasoconstriction?

A

Vasodilation (β2 more sensitive to epinephrine than α)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

High doses of epinephrine cause vasodilation/vasoconstriction?

A

Vasoconstriction (μαλλον εχουν περισσοτερους α)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Conscious proprioception (below the lesion) after complete transection of the spinal cord

A

Permanently lost (because of the interruption of sensory fibers)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Stretch reflexes (below the lesion) after complete transection of the spinal cord

A

Temporarily lost (because of the spinal shock) , return with time or become hypersensitive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Dihydropyridine receptors (heart)

A

Voltage-sensitive protein of the T tubules, L-type channels. During the plateau of the action potential Ca2+ enters the cells from extracellular fluid through these channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Ryanodine receptors (heart)

A

Ca2+ that enters the cell through the L-type channels (dihydropyridine receptors) triggers release of Ca2+ from the SR = Ca2+ -induced Ca2+ release)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Digitalis

A

Inhibits Na-K ATPase -> diminishes Na gradient -> diminishes Na-Ca exchange (that extrudes Ca) -> ^ intrac Ca

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Pulmonary blood flow greater than aortic blood flow

A

Left-to-right ventricular shunt

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

A pattern of two P waves preceding each QRS complex indicates

A

Decreased conduction velocity in the AV node

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

The greatest pressure decrease in the circulation occurs across ______
because

A

Across the arterioles because they have the greatest resistance (ΔP= Q x R)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Cushing reaction

A

=response to cerebral ischemia.
^ intracranial pressure ->
compression of the cerebral blood vessels ->
cerebral ischemia (^ CO2) ->
sympathetic outflow to the heart and blood vessels ->
PROFOUND INCREASE IN ARTERIAL PRESSURE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Hering-Breuer reflex

A

Lung stretch receptors: distention of the lungs –> reflex decrease in RR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

J (juxtacapillary) receptors

A

in the alveolar walls, close to the capillaries

Engorgement of the pulmonary capillaries (e.g. left heart failure) –> rapid, shallow breathing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Adaptation to high altitude

A
  • respiratory alkalosis (acetazolamide)
  • ^ EPO
  • ^ 2,3-DPG
  • Pulmonary vasoconstriction (hypertrophy if the right ventricle)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Mature levels of surfactant (can be reflected)
Lecithin:sphingomyelin ratio greater than 2:1
25
Major site of airway resistance in the lungs
Medium-sized bronchi | The smallest airways would seem to offer the highest resistance BUT parallel arrangement
26
Bohr effect
Increases in Pco2 / decreases in pH shift the curve to the right (e.g. during exercise: tissues produce more CO2)
27
Hemoglobin- O2 dissociation curve: | Shifts to the right
- increases in Pco2/decreases in pH - increases in temperature - increases in 2,3-DPG concentration
28
Hemoglobin- O2 dissociation curve: | Shifts to the left
- decreased Pco2/increased pH - decreased temperature - decreased 2,3-DPG (e.g. HbF) - CO poisoning
29
Cause of hypoxemia
- decreased PAo2 - diffusion defect - V/Q defects - right-to-left shunts
30
Abnormal A-a gradient
``` >10mm Hg Causes: -diffusion defect -V/Q defects -right-to-left shunts ```
31
Causes of Hypoxia
- decreased cardiac output / blood flow - hypoxemia - anemia (decreased hemoglobin concentration) - CO poisoning - Cyanide poisoning
32
Pulmonary blood flow greater than aortic blood flow
Left-to-right shunt: In normal adults,output of left ventricle=output of right ventricle. When defect in ventricular septum (left-to-right shunt) the "shunted" fraction of the left ventricular output is added to output of the right ventricle
33
Chemoreceptors in control of breathing
- CENTRAL - Medulla : pH - PERIPHERAL - Carotid bodies : Po2 (if <60mm Hg) , Pco2
34
NH3 synthesis in acidosis
Adaptive increase in NH3 synthesis (in the renal cells --> diffuses down its concentration gradient from the cells into the lumen --> combines with H+ to form NH4+ --> NH4+ is excreted)
35
TBW is highest in
Newborns and adult males
36
TBW is lowest in
Adult females and in adults with a large amount of adipose tissue
37
Major ions of ICF
Cations: K+ and Mg2+ Anions: protein and organic phosphates (ATP,ADP,AMP)
38
Substances with the lowest clearances
- not filtered: protein | - reabsorbed: Na+, glucose, amino acids, HCO3-, Cl-
39
Major ions of ECF
Cations: Na+ Anions: Cl- and HCO3-
40
Measuring the volumes of the fluid compartments-Markers
- Tritiated water: for TBW (wherever water is found) - Mannitol: for ECF (too large to cross membranes) - Evans blue: for plasma (binds to serum albumin)
41
Proximal tubule
``` EARLY Reabsorbs: -Na+ -H2O (TF/PNa+=1.0) -HCO3- -glucose -amino acids -phosphate -lactate ``` Secretes: -H+ LATE Reabsorbs: -Na+ with Cl-
42
Water clearance = 0
During treatment with loop diuretics: Inhibits NaCl reabsorption in the thick ascending limb---> -inhibits dilution in the thick ascending limb -inhibits production of the corticopapillary osmotic gradient ---> URINE CANNOT BE DILUTED OR CONCENTRATED
43
Glomerulotubular balance
In the proximal tubule maintains constant fractional reabsorption (=67%) of the filtered Na+ and H2O ασχετα απο GFR thanks to Starling forces, πc in the peritubular capillary blood
44
Thick ascending limb of the loop of Henle-Potential
Lumen-positive potential difference: | Although the Na+-K+-2Cl- cotransporter appears to be electroneutral, some K+ diffuses back into the lumen
45
Loop diuretics
Furosemide, ethacrynic acid, bumetanide | Inhibit the Na+-K+-2Cl- cotransporter at the thick ascending limb of the loop of Henle
46
Thiazide diuretics
Inhibit the Na+-Cl- cotransporter at the early distal tubule
47
How much of the overall Na+ reabsorption is affected by aldosterone?
About 2%
48
K+ -sparing diuretics
Spironolactone (antagonist of aldosterone) Triamterene, amiloride (act directly on the principal cells) Decrease K+ secretion in principal cells at the late distal tubule and collecting duct
49
Acetazolamide
Diuretic - Carbonic anhydrase inhibitor | In the early distal tubule by inhibiting the reabsorption of filtered HCO3-
50
K+ excretion
Can vary widely from 1% to 110% | Depending on dietary K+ intake, aldosterone levels and acid-base status (and flow rate)
51
K+ excretion
Can vary widely from 1% to 110% Depending on dietary K+ intake, aldosterone levels and acid-base status and flow rate (e.g. thiazide increase flow rate at the site of distal tubular secretion --> K+ excretion is increased)
52
Causes of shift of K+ out of cells ---> Hyperkalemia
``` Insulin deficiency β-adrenergic antagonists Acidosis Hyperosmolarity Inhibitors of Na+-K+ pump (digitalis) Exercise Cell lysis ```
53
Causes of shift of K+ into cells ---> Hypokalemia
Insulin β-adrenergic agonists Alkalosis Hyposmolarity
54
Increase of RBF
``` Caused by Vasodilation of renal arterioles produced by -prostaglandins E2 and I2 -bradykinin -nitric oxide -dopamine ``` Vasodilation of afferent and,to a lesser extent, vasoconstriction of efferent arterioles Produced by Atrial natriuretic peptide (ANP)
55
Buffers
Extracellular: - HCO3- (CO2/HCO3- pK=6.1) - Phosphate (H2PO4-/HPO4-2 pK=6.8) --> URINARY BUFFER Intracellular - Organic phosphates (AMP,ADP,ATP, 2,3-DPG) - Proteins: imidazole, α-amino groups, Hemoglobin (deoxy)
56
Concentration of inulin in the tubular fluid reflects
The amount of water remaining in the tubule because inulin once filtered us neither reabsorbed nor secreted
57
Hypermagnesia
Hypocalcemia <---- increased Ca2+ clearance | Because Mg2+ competes with Ca2+ for reabsorption in the thick ascending limb
58
How alkalosis affects K+
Reduced [H+] in blood will cause intracellular H+ to leave cells in exchange for extracellular K+
59
Filtration fraction=
The fraction of RPF filtered across the glomerular capillaries = GFR/RPF normally about 0.20 Increases--->^protein concentration of peritubular capillary blood---> ^reabsorption in the proximal tubule Decreases---> decreased protein concentration of peritubular capillary blood ---> decreased reabsorption in the proximal tubule D
60
How oxygen deprivation affects reabsorption in the proximal tubule?
Would inhibit reabsorption by stopping the Na+-K+ pump in the basolateral membranes
61
RBF=
RPF/1-Hct= Cpah/1-Hct = (Upah x V/Ppah)/1-Hct
62
Regulation of gastrin secretion
Stimuli for secretion: -small peptides and amino acids most potent phenylalanine and tryptophan -distention of the stomach -vagal stimulation mediated by gastrin-releasing peptide (GRP) NOT ACh!!! (not blocked by atropine) Inhibition of gastrin secretion: - H+ in the lumen of the stomach (negative feedback) - Somatostatin
63
HCO3- reabsorption in metabolic alkalosis
Normally increased excretion of HCO3- because the filtered load of HCO3- exceeds the ability of the renal tubule to reabsorb it BUT If metabolic alkalosis is accompanied by volume contraction (e.g. vomiting) the reabsorption of HCO3- increases (contraction alkalosis)
64
Striated muscle in the GI tract
Pharynx, upper one-third of the espphagus and external anal sphincter
65
Respiratory alkalosis-muscle symptoms
Tingling, numbness, muscle spasm= HYPOCALCEMIA H+ and Ca2+ compete for binding sites on plasma proteins Decreased [H+] --> ^ protein binding of Ca2+ and decreased free ionized Ca2+
66
Salicylate intoxication
-METABOLIC ACIDOSIS salicylate acid , ^anion gap -RESPIRATORY ALKALOSIS Direct stimulation of medullary respiratory center
67
Parasympathetic innervation of the GI tract (parts)
Vagus: esophagus,stomach,pancreas,upper large intestine Pelvic: lower large intestine,rectum,anus
68
Absorption of vitamins
FAT-SOLUBLE (A,D,E,K) : incorporated into micelles and absorbed along with other lipids WATER-SOLUBLE: (most) by Na+ -dependent cotransport mechanisms VITAMIN B12 : requires intrinsic factor (secreted by parietal cells) vitamin B12-intrinsic factor complex binds to a receptor in the ILEAL cells and is absorbed
69
"Official" GI hormones
Gastrin Cholecystokinin (CCK) Secretin Glucose-dependent insulinotropic peptide (GIP)
70
Actions of gastrin
^ Gastric H+ secretion | Growth of gastric mucosa
71
"Official" GI hormones
Gastrin Cholecystokinin (CCK) Secretin Glucose-dependent insulinotropic peptide (GIP)
72
Actions of gastrin
^ Gastric H+ secretion | Growth of gastric mucosa
74
Actions of CCK
1) contraction of the gallbladder/relaxation of the sphincter of Oddi 2) pancreatic enzyme secretion 3) potentiates secretin-induced stimulation of pancreatic HCO3- secretion 4) growth of the exocrine pancreas 5) inhibits gastric emptying!
75
Actions of secretin
1) pancreatic HCO3- secretion + growth of the exocrine pancreas 2) HCO3- and H2O secretion by the liver + bile production 3) INHIBITS H+ secretion by the parietal cells
76
Stimuli for the release of GIP
Fatty acids Amino acids and ORALLY administered glucose [---> oral glucose is more effective than intravenous glucose in causing insulin release]
77
GLP-1
binds to pancreatic β-cells and stimulates insulin secretion [analogues may be helpful in the treatment of type 2 diabetes mellitus]
78
Somatostatin actions
inhibits secretion of all GI hormones!! | + inhibits gastric H+ secretion
79
Neurocrines of the GI tract
VIP (vasoactive intestinal peptide) GRP (bombesin) Enkephalins
80
Basis for the usefulness of the OPIATES in the treatment of diarrhea
Enkephalins inhibit intestinal secretion of fluid and electrolytes
81
Striated muscle in the GI tract
Pharynx, upper one-third of the esophagus and external anal sphincter
82
Interstitial cells of Cajal
pacemaker of the GI smooth muscle | produce slow waves
83
Slow waves (mechanism)
cyclic opening of the Ca2+ channels followed by opening of K+ channels depol brings the membrane potential closer to threshold --->increases the probability that action potentials will occur
84
How to measure intrathoracic pressure
Using a balloon catheter placed in the esophagus | [lower than atmospheric]
85
Relaxation of the Lower Esophageal Sphincter- How
Vagally mediated and the neurotransmitter is VIP
86
When is gastric emptying inhibited/slowed?
1) when the stomach contents are hypertonic or hypotonic 2) fat (CCK) 3) H+ in the duodenum (direct neural reflexes)
87
Components of the gastrocolic reflex
- rapid parasympathetic component | - slower hormonal component mediated by CCK and gastrin
88
Mechanism of Protein absorption
LUMEN --> INTESTINAL CELL: Na+ - dependent cotransport (amino acids) H+ - dependent cotransport (di- and tripeptides) INTESTINAL CELL --> BLOOD Cytoplasmic peptidases hydrolyze di- and tripeptides to amino acids All amino acids are transported by facilitated diffusion
89
Pancreatic secretions are ...tonic
Always isotonic, regardless of flow rate
90
Hormones of the anterior lobe if the pituitary
1) Growth hormone 2) Prolactin 3) TSH 4) LH 5) FSH 6) ACTH
91
Which hormones are derived from POMC
ACTH MSH (α- and β-) β-lipotropin β-endorphin
92
Regulation of ADH secretion
Increased by: - ^ serum osmolarity - volume contraction - pain - NAUSEA - hypoglycemia - nicotine, opiates, antineoplastic drugs Decreased by: - decr serum osmolarity - ethanol - α-agonists - ANP
93
How hepatic failure affects thyroid hormones
TBG levels decrease --> decrease in total thyroid hormone levels but normal levels of free hormone
94
How pregnancy affects thyroid hormones
TBG levels increase --> increase in total thyroid hormone but normal levels of free hormone = clinically EUTHYROID
95
Thyroid hormones effect on Basic Metabolic Rate (BMR)
O2 consumption and BMR are increased in all tissues EXCEPT brain gonads and spleen due to increase of the synthesis of Na+,K+ ATPase
96
How does thyroid hormone have same actions as the sympathetic NS
up-regulates β1-adrenergic receptors in the heart
97
How glucocorticoids stimulate gluconeogenesis
1) ^ protein catabolism in muscle (and decrease protein synthesis) --> ^ amino acids provided to the liver for gluconeogenesis 2) decrease glucose utilization and insulin sensitivity of adipose tissue 3) ^ lipolysis --> ^ glycerol provided to the liver for gluconeogenesis
98
Anti-inflammatory effects of glucocorticoids (mechanism)
1) induce synthesis of LIPOCORTIN = (-) phospholipase A2 ---> (-) liberation of arachidonate from membrane phospholipids ---> (-) synthesis of prostaglandin and leukotriene 2) (-) production of IL-2 / proliferation of T lymphocytes 3) (-) release of histamine and serotonin from mast cells and platelets
99
Actions of glucocorticoids (in general)
1) Stimulation of gluconeogenesis 2) Anti-inflammatory effects 3) Suppression of the immune response 4) Maintenance of vascular responsiveness to catecholamines (up regulation of α1 - vasoconstriction)
100
Actions of mineralocorticoids
PRINCIPAL - ^ renal Na+ reabsorption - ^ renal K+ secretion α-INTERCALATED - ^ renal H+ secretion
101
Differences between Secondary adrenocortical insufficiency and Addison disease
Addison disease =primary adrenocortical insufficiency Secondary adrenocortical insufficiency = primary deficiency of ACTH DIFFERENCES: In Secondary : - NOT hyperpigmentation (because no ACTH) - NOT volume contraction, hyperkalemia or metabolic acidosis (aldosterone levels are normal)
102
Hormone levels in 21β-Hydroxylase deficiency
Decrease in cortisol and aldosterone (and gonadal hormones?) ``` Increase in ACTH adrenal androgens 17-hydroxyprogesterone and progesterone ```
103
Hormone levels in 17α-hydroxylase deficiency
Decrease in androgen and glucocorticoids Increase in mineralocorticoid and ACTH
104
Why hypotension in diabetes mellitus
Result of ECF volume contraction. high blood glucose --> high filtered load of glucose --> exceeds reabsorptive capacity (Tm) of the kidney --> unreabsorbed glucose acts as an osmotic diuretic
105
When does ovulation occur
14 days before menses REGARDLESS of cycle length
106
Basal body temperature during luteal phase
Increases because of the effect of progesterone on the hypothalamic thermoregulatory center
107
Major placental estrogen (second and third semester)
Estriol
108
Human Placental Lactogen
produced throughout pregnancy | actions similar to growth hormone and prolactin
109
Amine hormones
Thyroid, epinephrine , norepinephrine | = derivatives of tyrosine
110
Regulation of growth hormone secretion
Increased by Sleep, stress, hormones related to puberty, starvation, exercise, hypoglycemia Decreased by Somatostatin, somatomedins, obesity, hyperglycemia, pregnancy
111
Prolactin excess
Results from: - hypothalamic destruction - prolactinoma Causes: - galactorrhea - decreased libido - failure to ovulate and amenorrhea Treated with: bromocriptine
112
Actions of ADH
1) ^ H2O permeability (aquaporin 2) on the principal cells of late distal tubule and collecting ducts (V2 receptor) 2) constriction of vascular smooth muscle cell (V1 receptor)
113
Why give oxytocin
- to induce labor | - to reduce postpartum bleeding
114
Iodide pump/Na+ - I- contrasporter is inhibited by
thiocyanate and perchlorate anions
115
Peroxidase in the follicular cell membrane is inhibited by
Propylthiouracil | --->used therapeutically to reduce thyroid hormone synthesis for the treatment of hyperthyroidism
116
Wolff-Chaikoff effect
High levels of I- inhibit organification ---> inhibit synthesis of thyroid hormone
117
T3/T4 is more biologically active?
T3
118
Hormones that regulate prolactin secretion
Dopamine inhibits | TRH increases
119
Actions of ACTH
- Stimulates cholesterol desmolase --> (+) conversion of cholesterol to pregnenolone - Up-regulates its own receptor at the adrenal cortex - When chronically increased --> hypertrophy of the adrenal cortex
120
Actions of dexamethasone
Inhibits ACTH secretion (dexamethasone suppression test)
121
Dexamethasone suppression test
High or low dose and | measure CORTISOL levels
122
Regulation of aldosterone secretion
``` -tonic control by ACTH BUT -separately regulated by the renin-angiotensin system and -serum K+ ```
123
Negative Ca2+ balance
=Intestinal Ca2+ absorption
124
Positive Ca2+ balance
Intestinal Ca2+ absorption > Ca2+ excretion In growing children The excess is deposited in the growing bones
125
How serum [Mg2+] affects PTH secretion
- Mild decreases in serum [Mg2+] stimulate PTH secretion | - Severe decreases in serum [Mg2+] inhibit PTH secretion ---> symptoms of hypoparathyroidism (hypocalcemia)
126
How is resorption of the organic matrix of bone reflected
Increased hydroxyproline excretion
127
Urinary Ca2+ excretion in primary hyperparathyroidism
INCREASED because of the increased filtered load (exceeds Tm)
128
Chronic renal failure - Ca2+
1) decreased production of 1,25-dihydroxycholecalciferol contributes to decreased ionized [Ca2+] 2) decreased GFR --> decreased filtration of phosphate --> phosphate retention --> ^ serum [phosphate] --> complexes Ca2+ --> decreased ionized [Ca2+] --> SECONDARY HYPERPARATHYROIDISM
129
Familial hypocalciuric hypercalcemia
Inactivating mutations of the Ca2+ -sensing receptors that regulate PTH secretion Autosomal dominant Decreased urinary Ca2+ excretion and ^serum Ca2+
130
Variation of FSH and LH levels over the life span
CHILDHOOD: hormone levels are lowest , FSH>LH PUBERTY AND REPRODUCTIVE YEARS: hormone levels increase , LH>FSH SENESCENCE: hormone levels are highest , FSH>LH
131
Levels of HCG during pregnancy
Peak levels at gestational week 9 and then decline
132
Estrogen production during the second and third semester
FETAL ADRENAL GLAND: dehydroepiandrosterone-sulfate (DHEA-S) --> hydroxylated in the FETAL LIVER -->PLACENTA: enzymes remove sulfate and aromatize to estrogens [major placental estrogen: estriol]
133
Factors that decrease the duration of REM sleep
Benzodiazepines | Increasing age
134
At which phase of the cardiac cycle(+ECG) is the aortic pressure lowest
Just before the ventricle eject (between isovolumetric contraction and rapid ventricular ejection) - After the QRS
135
Factors that may destroy the BBB
Inflammation Irradiation Tumors
136
Oxygen-hemoglobin dissociation curve in co poisoning
Shift to the left BUT also decrease in total O2-binding capacity --->decreased maximum percent saturation (max= 50%)
137
Where is estradiol synthesized
Testosterone is synthesized in ovarian theca cells and diffuses to ovarian granulosa cells where it is converted to estradiol by aromatase. FSH stimulates aromatase
138
How hypercalcemia affects the action of ADH
With severe hypercalcemia, Ca2+ accumulates in the inner medulla and papilla of the kidney
139
Diuretics and Ca2+
LOOP: Ca2+ reabsorption is linked to Na+ reabsorption in the loop of Henle --> inhibiting Na+ with a loop diuretic also inhibits Ca2+ reabsoption---> loop diuretics increase Ca2+ excretion ---> treatment of hypercalcemia (volume to be replaced) THIAZIDE: increase Ca2+ reabsporption in the early distal tubule --> decrease Ca2+ excretion ---> treatment of idiopathic hypercalciuria
140
How ^ intracellular Ca2+ excitates smooth muscle cell
binds to calmodulin
141
Difference between action potential of a ventricular muscle cell and an atrial muscle cell
atrial muscle cells have a much shorter plateau phase and a much shorter overall duration
142
Causes of nephrogenic diabetes insipidus
- Lithium intoxication: inhibits the Gs protein in collecting duct cells - Hypercalcemia: inhibits adenylate cyclase
143
Diuretics and Ca2+
LOOP: Ca2+ reabsorption is linked to Na+ reabsorption in the loop of Henle --> inhibiting Na+ with a loop diuretic also inhibits Ca2+ reabsoption---> loop diuretics increase Ca2+ excretion ---> treatment of hypercalcemia (volume to be replaced) THIAZIDE: increase Ca2+ reabsporption in the early distal tubule so that urinary Na+ excretion is increased --> decrease Ca2+ excretion ---> treatment of idiopathic hypercalciuria
144
COPD causes ....ventilation
hypoventilation
145
K+ in vomiting
Hypokalemia because - loss of gastric K+ - ^aldosterone due to volume contraction
146
No p waves and bizarre QRS complexes | Where did they originate
NOT SA node (no p) NOT AV node (bizarre and not normal QRS) NOT VENTRICULAR MUSCLE (no pacemaker activity) !His-Purkinje system yes (pacemaker activity but not normal QRS)
147
Metabolic acidosis + decreased urinary excretion of NH4+ =
Chromic renal failure
148
Which GI hormones are secreted by cell of the duodenum
Secretin and CCK