Physiology & Biochemistry

Question 1

Conditions associated with a raised Leucocyte alkaline phosphatase

Answer 1

Myelofibrosis
Leukaemoid reactions
Polycythaemia Vera
Infections
Steroids, Cushing's syndrome
Pregnancy, oral contraceptive pill

Question 2

Conditions associated with a low Leucocyte alkaline phosphatase

Answer 2

Chronic myeloid leukaemia
Pernicious anaemia
Paroxysmal nocturnal haemoglobinuria
Infectious mononucleosis

Low LAP levels are found in conditions associated with immature/undeveloped WBCs (e.g. CML)