Physiology and Pharmacology 3: Flashcards
1
Q
Example of reversible antagonism?
A
Effect of atropine on response to ACh in guinea pig ileum
2
Q
What is Dose Ratio? Equation?
A
How many more times agonist is needed in presence of an antagonist
conc. of agonist in presence on antagonist /
conc. of agonist in absence of antagonist
3
Q
what is pA2? changing the value affects what?
A
measure of affinity of the antagonist for its receptor
high pA2 = more potent antagonist
4
Q
schild plots
A
graphs look at them
