Physiology Flashcards
Site of E production in postmenopausal age ?
E1
Produced from adipose tissue.
Androstenidione —> E1 by Aromatase
Aromatase inhib if given produce hypoestrogenic state.
Site of production of E in reprod age group?
Ovary
E2
Theca cells & granulosa cells
2nd –> corpus luteus
Site Of E3 production?
During pregnancy
Site –> placenta
From fetal dheas
Site Of E3 production?
During pregnancy
Site –> placenta
From fetal dheas
Inhibin A & B inhibits?
Fsh
In which natural methods of contraception min no of days of abstinence ?
Calender method
Effect of E on Lh & Fsh?
E inhib to FSh E to LH •low dose stimulatory +ve feedback •high dose inhib. -ve feedback Propsed mech : Neuroendocrine phenom.
Effect of P on LH & FSH
P
•at low dose stim for both
•at high dose inhib for both
Effect of testosterone on SHBG?
Inhibitory
Max activity of C luteum ?
8th day post ovulation.
It produces - prog ,e ,inhib A ,relaxin
Inhibin b - granulosa cells of GF
Gnrh released from ?
Arcuate N which derive neuron from olfactory placode
Neurotransmitter release which cause pulsatile release of gnrh ?
Inc - kisspeptin leptin glutamate Dec - gaba neuropeptide Single best - kisspeptin Inhib - gaba Release of gnrh dormant till puberty these neurotransmitter mediate release.
Puberty initially anovulatory?
Bcz initially only lh pulsatile release and at night only. Later both pulsatile
Anovulatory due to absence of fsh.
Puberty initially anovulatory?
Bcz initially only lh pulsatile release and at night only. Later both pulsatile
Anovulatory due to absence of fsh.
Hot flushes coincide with
LH surge
After menopause hormones?
Decr - E
Incr - LH ,FSH
Ovarian androgen production continues
Androstenidione conversation to E1 at periphery ; obese pt inc estrogen
POF mx?
HRT till menopause
