Physiology Flashcards
physiology
analysis of the function of living organisms; applies physical and chemical methods to biology
comparative
study of the diversity and modulation of highly conserved properties of organisms
comparative physiology contributes to:
ecology - describes adaptations to diverse environment
evolution - correlates function with structure which can help determine relatedness
adaptation
a trait that improves an organisms performance (fitness) in its environment
homeostasis
any self-regulating process by which biological systems tend to maintain stability while adjusting to conditions that are optimal for survival
3 functional components to homeostasis
- receptor - takes in sensory information
- control center - determines the set point and regulates the body’s response
- effector - carries out the response
doping drugs
- PEDS
- Anabolic steroids
- HGH
- EPO - erythropoietin
- Testosterone
Peds
build muscle mass and strength
increase oxygen delivery to exercising tissue
mask pain and injury
decrease weight
anabolic steroids
stumulate muscle and bone cells to make new protein by changing gene expression
increases protein synthesis capacity of the cell
Testosterone
causes male reproductive and secondary sex traits
side effects:
males- balding, infertility
females- facial hair, thicken vocal cords
general- increased heart disease, liver cancer, kidney damage
HGH
naturally occurring protein produced by pituitary gland stimulates bone and muscle growth and reduces body fat side effects: type 1 diabetes acromegaly- overgrowth of hands, feet and face heart problems kidney failure with long term use
influence of physics on physiology:
- gravity - circulation, movement and locomotion
2. surface area: volume - respiration, digestion, water balance, thermoregulation
isometric scaling
everything grows in proportion
allometry
the study of differential growth; biological scaling
if body temp is too high…
proteins denature
inadequate O2 supply (affinity for Hb decreases with increasing temperature)
membrane structure alterations
if body temp is too low …
metabolism isn’t fast enough to maintain homeostasis
freezing of cells
inadequate O2 supply
4 methods of human heat exchange:
- Radiation - infared wavelength without contact 60% heat loss
- Conduction - direct transfer 3%
- Convection - air/fluid across body surface 15%
- Evaporation - water from body surface 22%
poikilotherms
ectotherms - temp fluctuates with environment (conformers)
homeotherms
endotherms - constant body temp (regulators), heat derived from metabolism
poikilotherm (ectotherm) benefits:
5x slower metabolic rate than homeotherms
can devote larger proportion of energy budget to reproduction
good colonisers of poor/arid environments
poikilotherm (ectotherm) costs:
no nocturnal environmental niches
cannot sustain high activity bursts - go to anaerobic = high lactic acid = rapid fatigue
homeotherm benefits:
can sustain high activity bursts
nocturnal activity in all habitats
able to exploit colder habitats
forage widely and migrate over long distances
homeotherm costs
require large body sizes with relatively low SA;Volume
fast metabolic rate
bad colonisers of poor/arid environments
thermoneutral zone
range of temps in which the animal doesn’t have to expend energy to maintain body temp
hyperthermia
when evaporative cooling cannot counteract heat gain; body temp is above normal and cannot be reduced
vasoconstriction (warms)
diameter of blood vessel decreases
blood flow to skin decreases
less heat lost to environment
raises internal temp
shivering
skeletal muscles consume ATP and generate heat
countercurrent heat exchange
hot artery flows by colder veins and exchanges heat so cold blood doesn’t flow to heart
brown fat
has lots of mitochondria and a richer blood supply - new borns and hibernators
hormones that increase cellular metabolism:
Adrenaline - released from adrenal medulla, stimulate flight or fight which increases heart rate
Thyroxine - hypothalamus signals thyroid to release thyroxine = elevates metabolic rate
vasodilation (cools)
blood vessels dilate
blood moved to skin and blood heat is lost to environment
2 main concerns of water balance:
- balance uptake of water from and loss to external environment
- reduce build up of toxic by products of metabolism
passive movement
along a concentration gradient
active movement
add energy to move against concentration gradient
influences of rate of passive movement
membranes size of ion temp of solution electrical charge of ion concentration gradient
osmolarity equation
(particles/molecule of solute) x (moles/litres)